The Handbook of Cannabis Therapeutics

Name: The Handbook of Cannabis Therapeutics | From Bench to Bedside
Brand: Routledge
Price: 60.09 EUR
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From Bench to Bedside

Ethan B. Russo Franjo Grotenhermen(Herausgeber*in)

Routledge (Verlag)

1. Auflage

Erschienen am 22. Mai 2014

496 Seiten

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Beschreibung

Learn the facts behind the pharmacology and pharmacokinetics of controversial cannabis therapeutics

The Handbook of Cannabis Therapeutics: From Bench to Bedside sets aside the condemnation and hysteria of society's view of cannabis to concentrate on the medically sound aspects of cannabis therapeutics. The world's foremost experts provide a reasoned, thoroughly researched overview of the controversial subject of cannabis, from its history as a medicine through its latest therapeutic uses. The latest studies on the botany, history, biochemistry, pharmacology, toxicology, clinical use for various illnesses such as AIDS, epilepsy, and multiple sclerosis, and side effects of marijuana are all examined and discussed in depth.

This comprehensive resource is a compendium of articles from the Journal of Cannabis Therapeuticswith additional contemporary commentary. It presents startling research that explores and supports the medicinal value of cannabis use and its derivatives as a valid therapeutic resource for pain and inflammation, for several illnesses less responsive to other therapies, and even for certain veterinary uses. Cannabinoids such as nabilone, THC, levonantradol, ajulemic acid, dexanabinal, and others are extensively described, with a review of new indications for cannabinoid pharmaceuticals. The book is carefully referenced to encourage your examination of previous studies and provides tables and figures to enhance understanding of information.

The Handbook of Cannabis Therapeutics discusses:

the uses of cannabis in Arabic, Greek, Roman, and early English medicines

absorption rates

pharmacokinetics

pharmacodynamics

separate extracts versus the use of cannabis in its entirety

the therapeutic value of the endocannabinoid system

cannabinoids and newborn feeding

a comparison of smoking versus oral preparations

clinical research data on eating cannabis

therapeutic uses as appetite stimulant

treatments in obstetrics and gynecology

medicinal treatments used in Jamaica

the use of cannabis in the treatment of multiple sclerosis

the benefits versus the adverse side effects of cannabis use

The Handbook of Cannabis Therapeutics is a reference work certain to become crucial to physicians, psychologists, researchers, biochemists, graduate students, and interested members of the public.

Weitere Details

Weitere Ausgaben

Personen

Inhalt

About the Editors

Contributors

Foreword

Introduction (Franjo Grotenhermen)

PART I: HISTORICAL NOTES

Chapter 1. The Therapeutic Use of Cannabis sativa L. in Arabic Medicine (Indalecio Lozano)

Introduction

Materials and Methods

Results

Conclusion

Update

Chapter 2. Cognoscenti of Cannabis I: Jacques-Joseph Moreau (1804-1884) (Ethan B. Russo)

Chapter 3. Cognoscenti of Cannabis II: Simeon Seth on Cannabis (David Deakle)

Chapter 4. The Medical Use of Cannabis Among the Greeks and Romans (James L. Butrica)

Introduction

Absence of Mention

The Emergence of Cannabis

Appendix I: Passages Discussing Wild Cannabis Possibly Misunderstood As Discussing Domesticated Cannabis

Appendix II: Cannabis in Veterinary Medicine

Update

Chapter 5. A Homelie Herbe: Medicinal Cannabis in Early England (Vivienne Crawford)

Introduction

Cannabis History in England

The Modern Era

Update

Chapter 6. Future of Cannabis and Cannabinoids in Therapeutics (Ethan B. Russo)

Introduction

New Indications for Cannabinoid Pharmaceuticals

Cannabinoids and Neuroprotection

Spasmodic Disorders

Forbidden Territories

Update

PART II: PHARMACOLOGY AND PHARMACOKINETICS

Chapter 7. Clinical Pharmacokinetics of Cannabinoids (Franjo Grotenhermen)

Introduction

Pharmacokinetics of 9-THC

Absorption

Distribution

Metabolism

Course of Plasma Concentration of THC and Metabolites

Elimination

Time Effect Relationship

Pharmacokinetics of Other Cannabinoids

Metabolic Interactions

Conclusion

Chapter 8. Clinical Pharmacodynamics of Cannabinoids (Franjo Grotenhermen)

Introduction

Mechanism of Action

Cannabinoid Receptors

Endocannabinoids

Pharmacological Effects of THC

Toxicity

Psyche, Cognition and Behavior

Central Nervous System and Neurochemistry

Circulatory System

Some Other Organ Systems and Effects

Pharmacological Activity of THC Metabolites

Pharmacological Effects of Other Cannabinoids

Tolerance and Dependency

Therapeutic Uses

Hierarchy of Therapeutic Effects

Basic Research Stage

Drug Interactions

Conclusions

Update

Chapter 9. Cannabis and Cannabis Extracts: Greater Than the Sum of Their Parts? (John M. McPartland and Ethan B. Russo)

Introduction

Materials and Methods

Results and Discussion

Cannabinoids

Terpenoids

Flavonoids

Conclusions

Update

PART III: ENDOCANNABINOIDS AND CANNABINOID RECEPTORS

Chapter 10. The Endocannabinoid System: Can It Contribute to Cannabis Therapeutics? (Vincenzo Di Marzo)

The Endocannabinoid System

Endocannabinoid Pharmacology: More Than Meets the Eye

Levels of Endocannabinoids in Tissues: Physiology and Pathology

New Drugs from the Endocannabinoid System: Curative or Palliative?

Update

Chapter 11. Cannabinoids and Feeding: The Role of the Endogenous Cannabinoid System As a Trigger for Newborn Suckling (Ester Fride)

Interactions of the Endocannabinoids System with Hormones Regulating Food Intake

Endocannabinoids in Food Substances

Developmental Aspects of the Endocannabinoid-CB1 Receptor System

Blockade of CB1 Receptors in Newborn Mice

Mechanisms of the CB1 Receptor Blockade-Induced Growth-Stunting Effects

Conclusions

Update

PART IV: MEDICINAL USES

Chapter 12. Mariju

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