Molecular Recognition and Polymers

Name: Molecular Recognition and Polymers | Control of Polymer Structure and Self-Assembly
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Control of Polymer Structure and Self-Assembly

Vincent Rotello Sankaran Thayumanavan(Herausgeber*in)

Wiley (Verlag)

Erschienen am 11. Juli 2008

420 Seiten

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Inhalt

Intro
MOLECULAR RECOGNITION AND POLYMERS
CONTENTS
Preface
Acknowledgments
List of Contributors
List of Figures
List of Tables
Editor Biographies
PART I FUNDAMENTALS OF SUPRAMOLECULAR POLYMERS
1. A BRIEF INTRODUCTION TO SUPRAMOLECULAR CHEMISTRY IN A POLYMER CONTEXT
1.1. Introduction and Background
1.2. Main-Chain Versus Side-Chain Supramolecular Polymers
References
2. MOLECULAR RECOGNITION USING AMPHIPHILIC MACROMOLECULES
2.1. Introduction
2.2. Amphiphilic Block Copolymers
2.2.1. Nonspecific Interactions
2.2.2. Specific Interactions
2.3. Amphiphilic Homopolymers
2.3.1. Container Properties
2.3.2. Recognition of Protein Surfaces
2.3.3. Protein Sensing
2.3.4. Recognition and Detection of Peptides
2.4. Amphiphilic Dendrimers
2.5. Conclusions
Acknowledgment
References
3. SUPRAMOLECULAR CONTROL OF MECHANICAL PROPERTIES IN SINGLE MOLECULES, INTERFACES, AND MACROSCOPIC MATERIALS
3.1. Introduction and Background
3.2. Mechanical Properties of Linear SPs
3.3. Mechanical Properties of SP Networks
3.4. Mechanical Properties in SPs at Interfaces
3.5. Mechanical Forces and Supramolecular Interactions
3.6. Conclusions
References
PART II POLYMER FORMATION AND SELF-ASSEMBLY
4. HYDROGEN BOND FUNCTIONALIZED BLOCK COPOLYMERS AND TELECHELIC OLIGOMERS
4.1. Scientific Rationale and Perspective
4.2. Hydrogen Bonding Interactions in Macromolecular Design
4.2.1. Fundamentals of Hydrogen Bonding
4.2.2. Performance Advantages of Hydrogen Bond Containing Polymers
4.3. Hydrogen Bond Containing Block Copolymers
4.3.1. Block Copolymers Involving Single Hydrogen Bonding Groups
4.3.2. Nucleobase Containing Hydrogen Bonding Block Copolymers
4.3.3. Block Copolymers Containing DNA Oligonucleotides
4.3.4. Block Copolymers Containing Other Hydrogen Bonding Arrays
4.3.5. Order-Disorder Transitions (ODTs) in Hydrogen Bonding Block Copolymers
4.4. Telechelic Hydrogen Bond Functional Polymers
4.5. Combining Hydrogen Bonding with Other Noncovalent Interactions
4.6. Reversible Attachment of Guest Molecules via Hydrogen Bonding
4.7. Conclusions and Summary
References
5. NONCOVALENT SIDE CHAIN MODIFICATION
5.1. Introduction
5.1.1. Supramolecular Polymers
5.2. Strategies Toward Noncovalent Side Chain Functionalization of Polymeric Scaffolds
5.2.1. Side Chain Functionalization Using Hydrogen Bonding
5.2.2. Side Chain Functionalization Using Metal Coordination
5.2.3. Side Chain Functionalization Using Coulombic Interactions
5.3. Noncovalent Multifunctionalization of the Side Chains of Polymeric Scaffolds
5.3.1. Combination of Hydrogen Bonding and Metal Coordination Interactions
5.3.2. Combination of Hydrogen Bonding and Coulombic Charges
5.3.3. Multiple Hydrogen Bonding Interactions: Self-Sorting on Polymers
5.3.4. Terpolymer Functionalization Strategies: Combing Hydrogen Bonding, Metal Coordination, and Pseudorotaxane Formation
5.4. Applications of Noncovalently Functionalized Side Chain Copolymers
5.4.1. Self-Assembled Functional Materials
5.4.2. Network Formation Using Side Chain Supramolecular Polymers
5.5. Conclusions and Outlook
Acknowledgments
References
6. POLYMER-MEDIATED ASSEMBLY OF NANOPARTICLES USING ENGINEERED INTERACTIONS
6.1. Introduction
6.2. Design of Nanoparticles and Polymers
6.3. Self-Assembly of Polymer-Particle Nanocomposites
6.3.1. Control of Interparticle Spacing
6.3.2. Self-Assembly of Nanoparticles Mediated by Polymers on the Planar Substrates
6.3.3. Control of 3-D Hierarchical Organization in the Solution
6.4. Conclusions and Outlook
References
7. METALLOSUPRAMOLECULAR POLYMERS, NETWORKS, AND GELS
7.1. Introduction
7.2. Metal-Ligand Binding Motifs
7.3. Linear and Macrocyclic Main Chain MSPs
7.4. Metallosupramolecular Networks and Gels
7.5. Conclusion and Outlook
References
8. POLYMERIC CAPSULES: CATALYSIS AND DRUG DELIVERY
8.1. Introduction
8.2. Methods of Encapsulation
8.2.1. Coacervation
8.2.2. Interfacial Polymerization
8.2.3. Colloidosomes
8.2.4. Colloidal Templating
8.2.5. Vesicles
8.3. Catalyst Encapsulation
8.3.1. General
8.3.2. Encapsulated Catalysts
8.4. Drug Delivery with Microcapsules
8.4.1. Homogeneous Particles
8.4.2. Interfacial Polymerization
8.4.3. Colloidal Templates
8.4.4. Vesicles
8.5. Conclusion
References
9. SEQUENCE-SPECIFIC HYDROGEN BONDED UNITS FOR DIRECTED ASSOCIATION, ASSEMBLY, AND LIGATION
9.1. Introduction
9.2. General Design: Information-Storing Molecular Duplexes Based on the Recombination of H Bond Donors and Acceptors
9.3. Quadruply H Bonded Duplexes with Sequence-Independent Stability
9.4. Tuning Binding Strength by Varying the Number of Interstrand H Bonds
9.5. Probing Sequence Specificity
9.6. Unexpected Discovery: Duplexes Containing Folded Strands
9.7. Directed Assembly: Formation of ß-Sheets and Supramolecular Block Copolymers
9.7.1. Directed Assembly: Templated Formation of Two-Stranded ß-Sheets
9.7.2. Supramolecular Block Copolymers
9.8. Integrating Noncovalent and Covalent Interactions: Directed Olefin Metathesis and Disulfide Bond Formation
9.8.1. Templated Olefin Cross-Metathesis
9.8.2. Directed, Sequence-Specific Disulfide Cross-Linking in Water
9.9. Conclusions and Future Perspectives
Acknowledgments
References
10. BIOINSPIRED SUPRAMOLECULAR DESIGN IN POLYMERS FOR ADVANCED MECHANICAL PROPERTIES
10.1. Introduction
10.1.1. Design of Synthetic Polymers with High Order Structures
10.1.2. Biomimetic Design of Oligomers with High Order Structures
10.2. Biomimetic Concept of Modular Polymer Design
10.2.1. Titin as Model for Modular Polymer Designs
10.2.2. Biomimetic Modular Domain Strategy for Polymer Designs
10.3. Results and Discussion
10.3.1. Synthesis and Studies of 2-Ureido-4-pyrimidone (UPy) Modular Polymers
10.3.2. Synthesis and Single Molecule Nanomechanical Studies of Peptidomimetic ß-Sheet Modular Polymers
10.3.3. 3-D Network Polymers Containing Biomimetic Reversibly Unfolding Crosslinkers for Advanced Mechanical Properties
10.4. Conclusion and Perspective
Acknowledgments
References
11. STRUCTURE AND SELF-ASSEMBLY OF AMPHIPHILIC DENDRIMERS IN WATER
11.1. Introduction
11.2. Structure
11.2.1. Unimolecular Micelle Analogy
11.2.2. Location of Terminal Groups
11.2.3. Polyelectrolyte Dendrimers
11.3. Self-Assembly and Aggregation
11.3.1. Dendrimers and Dendrons
11.3.2. Linear-Dendritic Multiblock Copolymers
11.3.3. Hydrophilic-Hydrophobic Balance
11.3.4. Steric Impact of Dendritic Block
11.3.5. Rigid Linear Block Copolymers
11.3.6. Supramolecular Gels
11.4. Folded Amphiphilic Dendrimers
11.4.1. Conformational Switching in Water
11.4.2. Amphiphilic Self-Assembly of Peptide-Dendrons
11.5. Langmuir-Blodgett Monolayers
11.5.1. Effect of Hydrophobic/Hydrophilic Balance
11.5.2. Packing Effect
11.5.3. Photoresponsive Monolayers
11.5.4. Fullerene Monolayers
11.6. Conclusion
References
PART III BIOMOLECULAR RECOGNITION USING POLYMERS
12. COLORIMETRIC SENSING AND BIOSENSING USING FUNCTIONALIZED CONJUGATED POLYMERS
12.1. Introduction
12.2. PDA
12.2.1. Glycolipids
12.2.2. Other Ligands
12.2.3. Small Molecules
12.2.4. Cation and pH Sensors
12.2.5. Membrane-Binding Peptides
12.2.6. Membrane Active Enzymes
12.2.7. Pattern Recognition
12.2.8. Whole Cells
12.2.9. Supported PDAs
12.3. Polythiophenes
12.4. Other Materials
12.5. Conclusion
References
13. GLYCODENDRIMERS AND OTHER MACROMOLECULES BEARING MULTIPLE CARBOHYDRATES
13.1. Introduction
13.2. Dendrimers to Glycodendrimers
13.3. Multivalency
13.4. Heteromultivalent Carbohydrate Systems
13.5. Comments Regarding the Synthesis of Heteromultivalent Carbohydrate Systems
13.6. Electron Paramagnetic Resonance (EPR) Characterization of Heterogeneously Functionalized Dendrimers
13.7. Conclusions and Outlook
Acknowledgment
References
14. SUPRAMOLECULAR POLYMERIZATION OF PEPTIDES AND PEPTIDE DERIVATIVES: NANOFIBROUS MATERIALS
14.1. Introduction
14.2. Self-Assembly of Nanofibers Based on a-Helices
14.3. Nanofibers Self-Assembled from ß-Sheets
14.3.1. Helix-Sheet Conversion and Nanofiber Formation
14.3.2. Antiparallel ß-Sheet Based Nanofibers
14.3.3. Nanofibers Derived from Short Peptide Sequences
14.3.4. Parallel ß-Sheet Nanofibers
14.4. Collagen Mimetics
14.5. Conclusions
References
15. MOLECULAR IMPRINTING FOR SENSOR APPLICATIONS
15.1. Introduction to Sensing Platforms
15.1.1. Utility of MIPs
15.2. Synthesis of MIPs
15.2.1. General Types of Imprinted Polymers (Covalent and Noncovalent)
15.2.2. Types and Preparation of MIPs
15.2.3. Polymerization Conditions
15.3. Recognition Properties of MIPs
15.3.1. Binding Site Heterogeneity
15.3.2. Limitations of the Recognition Properties of MIPs
15.4. Polymer Formats and Morphologies
15.4.1. Ground MIP Particles
15.4.2. Thin Films and Membranes
15.4.3. Self-Assembled Monolayers
15.5. Application of MIPs in Sensing
15.5.1. General Considerations
15.5.2. Competitive Binding Assays
15.5.3. Mass-Sensitive Sensors
15.5.4. Optical MIP Sensors
15.5.5. Electrometrical MIP Sensors
15.6. Conclusions and Outlook
References
Index

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