Miniaturization of Analytical Systems

Preface.
1 Miniaturization in Analytical Chemistry.
1.1 Introduction.
1.2 Miniaturization as One of the Critical Trends in ModernAnalytical Chemistry.
1.3 Evolution in the Field of Analytical Miniaturization.
1.4 Classification of Miniaturized Analytical Systems andDefinition of Terms.
1.5 Theory of Miniaturization.
1.6 Features of Miniaturized Analytical Systems.
1.7 Incidences of Miniaturization in the Analytical Process.
1.8 Outlook.
References.
2 Tools for the Design of Miniaturized AnalyticalSystems.
2.1 Introduction.
2.2 Miniaturized Analytical Processes: The Downsizing andIntegrating Phenomena.
2.3 Microfluidic Devices.
2.4 Microtechnology.
2.5 MEMS and NEMS.
2.6 Outlook.
References.
3 Automation and Miniaturization of Sample Treatment.
3.1 Introduction.
3.2 Simplification of Sample Treatment: MicroextractionTechniques.
3.3 Simplification of Sample Treatment: Continuous FlowSystems.
References.
4 Miniaturized Systems for Analytical Separations I: SystemsBased on a Hydrodynamic Flow.
4.1 Introduction.
4.2 The Earliest Example of Miniaturization of a GasChromatograph and Some Other Developments.
4.3 Capillary Liquid Chromatography (CLC).
4.4 Liquid Chromatography on Microchips.
References.
5 Miniaturized Systems for Analytical Separations II: SystemsBased on Electroosmotic Flow (EOF).
5.1 Introduction.
5.2 CE on the Microchip Format.
5.3 Modes and Theories of CE Microchips.
5.4 Microfabrication Techniques.
5.5 Basic Fluidic Manipulation/Motivation: ElectrokineticInjection and Separation Protocols.
5.6 Electrochromatography in Microchip Format: Designs andApplications.
5.7 Comparison of Hydrodynamic and Electroosmotic Flow-drivenMiniaturized Systems.
5.8 Analytical Applications.
5.9 Outlook.
References.
6 Detection in Miniaturized Analytical Systems.
6.1 Introduction.
6.2 Laser-induced Fluorescence (LIF) Detection.
6.3 Electrochemical Detection (ED).
6.4 Microfluidics-MS Interfacing.
6.5 Unconventional Detection Methods.
6.6 Outlook.
References.
7 Miniaturization of the Entire Analytical Process I:Micro(nano)sensors.
7.1 Introduction.
7.2 Evolution of Sensors with Nanotechnology.
7.3 Micro(nano)sensors.
7.4 Nanoprobes for In Vivo Bioanalysis.
References.
8 Miniaturization of the Entire Analytical Process II: MicroTotal Analysis Systems (muTAS).
8.1muTAS, Microfluidics and Lab-on-a-Chip: Conceptsand Terminology.
8.2 Basic Concepts of Microfluidics: The Design of AnalyticalMicrosystems.
8.3 The Basics of Downscaling in Microsystems.
8.4 Microfluidic Platforms: Types, Principles andClassification.
8.5 Microfluidic Devices for Analytical Lab-on-a-ChipApplications.
8.6 Outlook.
References.
9 Portability of Miniaturized Analytical Systems.
9.1 Introduction.
9.2 Portable Gas Analysers.
9.3 Portable Electrochemical Analysers.
9.4 Portable Optical Analysers.
9.5 Portable Lab-on-a-Chip Analysers.
References.
10 Analytical Performance of Miniaturized AnalyticalSystems.
10.1 Introduction.
10.2 Quality Control in Miniaturized Systems.
10.3 Validation of Microsystems.
10.4 Qualification of Microsystems.
10.5 Robustness of Microsystems.
Further Reading.
Index.