The Chromosomal Imbalance Theory of Cancer

Introducing CancerBoveri's Theory of Cancer was Ahead of its Time: Aneuploidy theory "Got Lost".Genesis of "The Enemy Within"? Clonal cancer. Tumorigenic retroviruses. Dominate oncogenes. Tumor suppressor genes. Driver genes.Gene Mutation Theory of Cancer: "Carcinogens are mutagens". Retroviral oncogenes. Are "cellular oncogenes" like retroviral oncogenes? Updated gene mutation theory is popular but unconfirmed.The Chromosomal Imbalance Theory of Cancer: Heuristic explanation of how chromosomal imbalance (and not gene mutation) generates cancer phenotypes. Aneuploidy causes chromosomal instability-the hallmark of cancer. Cancer is a progressive somatic aneuploidy syndrome. Quantitative analysis of how aneuploidy generates new cellular phenotypes.Theory of Chromosomal Imbalance Solves Mysteries and Paradoxes: Carcinogenesis is dependent on aneuploidy and not mutation. Autocatalyzed progression of aneuploidy is carcinogenesis. Aneuploidy causes the Warburg effect by increasing ATP demand. Balanced mitotic forces and species-specific sequential chromatid separation may govern the rate of transformation. Cancer vaccine is very unlikely. "Cancers are a genuine type of species"New Perspectives for Cancer Prevention, Diagnosis and Therapy: International regulation of aneuploidy-inducing agents. Cancer detection. Cancer therapy.Conclusion