Mass Spectrometry in Drug Metabolism and Pharmacokinetics

Preface vii
About the Editor ix
Contributors xi
1. Evolving Role of Mass Spectrometry in Drug Discovery andDevelopment 1
Dil M. Ramanathan and Richard M. LeLacheur
2. Quantitative Bioanalysis in Drug Discovery and Development:Principles and Applications 87
Ayman El-Kattan, Chris Holliman, and Lucinda H. Cohen
3. Quadrupole, Triple-Quadrupole, and Hybrid Linear Ion TrapMass Spectrometers for Metabolite Analysis 123
Elliott B. Jones
4. Applications of Quadrupole Time-of-Flight Mass Spectrometryin Reactive Metabolite Screening 159
Jose M. Castro-Perez
5. Changing Role of FTMS in Drug Metabolism 191
Petia A. Shipkova, Jonathan L. Josephs, and Mark Sanders
6. High-Resolution LC-MS-Based Mass Defect FilterApproach: Basic Concept and Application in Metabolite Detection223
Haiying Zhang, Donglu Zhang, Mingshe Zhu, and Kenneth L.Ray
7. Applications of High-Sensitivity Mass Spectrometry andRadioactivity Detection Techniques in Drug Metabolism Studies253
Wing W. Lam, Cho-Ming Loi, Angus Nedderman, and DonWalker
8. Online Electrochemical-LC-MS Techniques forProfiling and Characterizing Metabolites and Degradants 275
Paul H. Gamache, David F. Meyer, Michael C. Granger, and Ian N.Acworth
9. LC-MS Methods with Hydrogen/Deuterium Exchange forIdentification of Hydroxylamine, N-Oxide, and Hydroxylated Analogsof Desloratadine 295
Natalia A. Penner, Joanna Zgoda-Pols, Ragu Ramanathan, Swapan K.Chowdhury, and Kevin B. Alton
10. Turbulent-Flow LC-MS: Applications for AcceleratingPharmacokinetic Profiling and Metabolite Identification 311
Joseph L. Herman and Joseph M. Di Bussolo
11. Desorption Ionization Techniques for Quantitative Analysisof Drug Molecules 341
Jason S. Gobey, John Janiszewski, and Mark J. Cole
12. MALDI Imaging Mass Spectrometry for Direct Tissue Analysisof Pharmaceuticals 359
Yunsheng Hsieh and Walter A. Korfmacher
Index 383