The Neurobiology, Physiology and Psychology of Pain focuses on bettering readers' understanding of acute and chronic pain. Featuring chapters on neurotransmitters, pharmacology, and brain imaging, this volume discusses, in detail, the mechanisms of pain and experimental studies undertaken to better understand the pathways involved. The translational work in this area has applicability for neurologists, anesthesiologists, pharmacologists, and anyone working in the intersection of these areas. This volume is integral for anyone interested in the molecular underpinnings of pain at every level.
- Provides comprehensive coverage on a broad range of topics related to the neuroscience of pain
- Contains an abstract, key facts, a mini dictionary of terms, and summary points to aid in understanding in each chapter
- Features chapters on molecular pathways, imaging and a deep look at behavior associated with the experience of pain
- Contains unique topics that will help readers navigate key areas for research and further clinical recommendations
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
Illustrationen
Approx. 125 illustrations
ISBN-13
978-0-12-820608-9 (9780128206089)
Schweitzer Klassifikation
I. Molecular and cellular aspects1. Gene expression, KCNQ/Kv7 channels and neuropathic pain 2. The NTRK1 gene and congenital insensitivity to pain3. Prdm12, a key transcriptional regulator of the nociceptive lineage4. Linking the genetics of fibromyalgia and painFernando 5. Fentanyl: Polymorphisms, and adverse events6. Propofol anesthesia and molecular changes in the brain7. Protein Kinase G is a Molecular Switch for Pain8. Adrenergic agonists and the mu opioid receptor 9. Inflammatory and neuropathic pain impact on the opioid function in the mesocorticolimbic systemL10. Clinacanthus nutans, analgesia and the l-arginine/nitric oxide-mediated/cyclic-guanosine monophosphate-independent pathway11. alpha2/3-selective GABAA receptor PAMs as pain medications 12. alpha5GABAA receptors and their role in pain perception 13. ATP sensitive potassium channels in pain and analgesia 14. Astrocyte-neuron lactate shuttle and pain15. Nociception and sweet solutions: applications to inflammatory pain 16. Interlinking Interleukin-33 (IL-33), neuroinflammation and neuropathic pain 17. Neurons of the parabrachial nucleus, nociceptive input and pain pathways 18. Anterior cingulate cortex, pain perception and pathological neuronal plasticity during chronic pain19. Sleep deprivation headaches and Fos immunohistochemistry20. Antinociceptive glucagon-like peptides21. Pain transmission and peripheral group III metabotropic glutamate receptors (mGluRs)22. TRPM -8 receptor and menthol in pain management
II. Physiology, imaging and physical recordings 23. Anesthetic and proconvulsant effects of ketamine on EEG 24. Electroencephalography and anesthetic doses of ketamine25. Linking heart function and analgesia26. Computed Tomography-guided procedures for epidural injections 27. Chronic pain: Linking deep brain stimulation and sensory functional MRI28. Neurocognition and placebo analgesia: linking in functional magnetic resonance imaging 29. Linking the cortex, functional spectroscopy and pain: features and applications30. Muscle origins of myofascial pain syndrome
III. Psychology and Behaviour31. Behavioral markers of pain32. Adverse life events, sensitization of spinal nociception, and chronic pain risk33. Cognitive-affective modulation of pain: The Placebo and nocebo phenomena and their impact on pain treatment34. Nociception-related behavioral phenotypes in adult zebrafish35. Pain, implantable pain devices and psychosocial aspects as a narrative36. Influence of psychological factors in myofascial pain
IV. Resources37. Resources
