Peptide and Peptidomimetic Therapeutics: From Bench to Beside offers applied, evidence-based instruction on developing and applying peptide therapeutics in disease treatment, driving drug discovery, and improving patient care. Here, researchers, clinicians and students will find tools to harness the full power of peptides and peptidomimetics and improve bioavailability, stability, efficiency and selectivity of new therapeutics and their application in treatment plans. More than 20 leaders in the field share their approaches for identifying and advancing peptide and peptidomimetic therapeutics. Topics examined run from "bench to bedside," beginning with fundamental peptide science, protein-protein interactions and peptide synthesis.
Later chapters examine modes for peptide drug delivery, including cell penetration peptide and peptidomimetic delivery, as well as the targeting of specific disease types, peptide therapeutics as applied to infectious disease, cancer, metabolic disorders, neurodegenerative disorders, and skin disorders, and antiparasitic and immunosuppressive peptidomimetics.
- Helps researchers and clinicians harness the full of power of peptides and peptidomimetics in their daily work and drug discovery
- Features chapters running from "bench to bedside, providing a thorough grounding in fundamental peptide science, drug delivery methods, and targeting of specific disease types
- Features chapter contributions from international leaders in peptide science and drug development
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
Illustrationen
Approx. 240 illustrations (20 in full color)
Dateigröße
ISBN-13
978-0-12-820447-4 (9780128204474)
Schweitzer Klassifikation
History1. Therapeutic peptides: historical perspectives and current development trends
Basic science2. Therapeutic peptidomimetics: targeting the undruggable space3. Tailoring peptides and peptidomimetics for targeting protein-protein interactions4. Advances in peptide synthesis5. Stapled peptidomimetic therapeutics6. Ring closing metathesis
Drug discovery7. The current state of backbone cyclic peptidomimetics and their application to drug discovery8. Pharmacokinetics and pharmacodynamics of peptidomimetics9. Formulations of peptides and peptidomimetics10. Cell-penetrating peptides11. Intracellular peptides as drug prototypes12. Applications of computational three-dimensional structure prediction for antimicrobial peptides
Therapeutic applications13. Knottin peptidomimetics as therapeutics14. Venom peptidomimetics as therapeutics15. Therapeutic peptides targeting protein kinase: progress, challenges and future directions, featuring cancer and cardiovascular disease16. Therapeutic peptidomimetics for infectious diseases17. Antiparasitic therapeutic peptidomimetics18. Peptides and antibiotic resistance19. Antimicrobial peptides and the skin and gut microbiomes20. Peptide and peptidomimetic based vaccines21. Therapeutic peptidomimetics for cancer treatment22. Immunomodulatory peptidomimetics for multiple sclerosis therapy - the story of glatiramer acetate (Copaxone)23. Therapeutic peptidomimetics in metabolic diseases24. Therapeutic peptidomimetics in anesthesiology25. Cardiovascular-derived therapeutic peptidomimetics in cardiovascular disease26. Non-cardiovascular-derived therapeutic peptidomimetics in cardiovascular disease
Drug development27. Clinical and preclinical data on therapeutic peptides28. Therapeutic peptides: manufacturing and market29. Future perspectives on peptide therapeutics
