The Gut Microbiome, An Issue of Gastroenterology Clinics of North America

Name: The Gut Microbiome, An Issue of Gastroenterology Clinics of North America | Gut Microbiome, An Issue of Gastroenterology Clinics of North America, E-Book
Brand: Elsevier
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Gut Microbiome, An Issue of Gastroenterology Clinics of North America, E-Book

Eamonn M. M. Quigley(Autor*in)

Elsevier (Verlag)

1. Auflage

Erschienen am 9. Februar 2017

100 Seiten

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978-0-323-50997-8 (ISBN)

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Beschreibung

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Inhalt

Intro
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Basic Definitions and Concepts: Organization of the Gut Microbiome
Key points
The microbiome in health: development, influences, and functions
From Culture to High-Throughput Sequencing and Beyond: A Layperson's Guide to the "Omics" and Diagnostic Potential of the Microbiome
Key points
Introduction
Sample types, collection, transport, and storage
Culture-based analysis of the gut microbiome
DNA extraction methods
Microbiota composition determination
Microbiome function
Computational approaches and requirements for new users
Diagnostic potential
Summary
Biology of the Microbiome 1: Interactions with the Host Immune Response
Key points
Introduction
Innate immune system
Adaptive immune system
Bacterial factors that influence mucosal immune responses
Microbiome effects early in life
Summary
Biology of the Microbiome 2: Metabolic Role
Key points
Introduction
Why do we need to know what metabolites are made?
How do assess them and what can we assess: Nuclear MR and mass spectrometry, what samples?
Examples of using metabolic profiling to study gut microbial functionality
Future directions
Summary
Diet and the Microbiome
Key points
Introduction: what is the microbiome?
General concepts and approaches of microbiome studies
The microbiome and inflammatory bowel disease
The conundrum of diet, microbiome, and irritable bowel syndrome
The future: shining light on microbial dark matter
Summary
Impact of Antibiotics on Necrotizing Enterocolitis and Antibiotic-Associated Diarrhea
Key points
Introduction
Necrotizing enterocolitis
Antibiotic-associated diarrhea
The Microbiome-Gut-Brain Axis in Health and Disease
Key points
Introduction
Brain-gut-microbiota communication
Brain-gut-microbiota axis and extremes of life
Irritable bowel syndrome as prototype
Depression
Autism
Parkinson disease
Psychobiotics
Summary
The Gut Microbiome in Irritable Bowel Syndrome and Other Functional Bowel Disorders
Key points
Irritable bowel syndrome and functional bowel disorders
The intestinal microbiota
The intestinal microbiota in functional bowel disorders
Summary and clinical implications
Small Intestinal Bacterial Overgrowth and Other Intestinal Disorders
Key points
Introduction
Etiologic factors and pathogenesis
How does small intestinal bacterial overgrowth cause gut dysfunctions?
Symptoms of small intestinal bacterial overgrowth
Clinical predictors of small intestinal bacterial overgrowth
Diagnosis of small intestinal bacterial overgrowth
Treatment of small intestinal bacterial overgrowth
Summary
The Esophageal and Gastric Microbiome in Health and Disease
Key points
Introduction
The esophageal microbiome in health
The esophageal microbiome in disease
Gastric microbiome in health
Gastric microbiota in disease
Effect of acid suppression on the gastric microbiome
The Gut Microbiota in Inflammatory Bowel Disease
Key points
Introduction
Broken biome or broken host?
The environmental influence on inflammatory bowel disease
Microbiota as a proxy marker of environmental influence in inflammatory bowel disease
The early life window of influence
A nexus of genes, immunity, and microbes
Who gets sick?
The microbiota at different phases of disease
The microbiota in inflammatory bowel disease
The gut virome and inflammatory bowel disease
The mycobiome and inflammatory bowel disease
Is the microbiota a plausible target for therapy or prophylaxis?
Fecal microbiota transplantation
Summary
Gut Microbiota and Complications of Liver Disease
Key points
Introduction
Nonalcoholic fatty liver disease
Alcoholic-related liver disease
Summary
Fecal Microbiota Transplantation
Key points
Introduction
History
Goal and effects of fecal microbiota transplantation
Screening and process of fecal microbiota transplantation
Indications for fecal microbiota transplantation
Adverse effects of fecal microbiota transplantation
Special populations
Future considerations/next steps
Index

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