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The book is divided into four parts: the first part introduces the basic concepts of nicotinamide coenzymes, the synthesis of nicotinamide coenzymes, intracellular distribution, and an overview of the main functions and detection methods so that readers can quickly understand the general feature and function of nicotinamide coenzymes; the second part describes the involvement of nicotinamide coenzymes in intracellular signal transduction and their roles in cellular physiological and biochemical processes to explain exactly how nicotinamide coenzymes work in the processes and enable readers to deeply understand the principle of nicotinamide coenzymes playing an important function; the third part describes the role of nicotinamide coenzymes in the pathophysiological process of diseases, tries to illustrate the specific mechanisms of their association with the occurrence of the diseases, and points out the potential value in future translational medicine research; the fourth part introduces the production technology of nicotinamide coenzymes, including precursors, the process of industrial production, and the application of nicotinamide coenzymes and precursors in health industry, medicine, and life science research. This book can be used as a reference book or textbook for undergraduate and graduate students of life sciences, basic and clinical medicine, researchers, and clinicians.
Zheng-Hong Qin, MD; PhD Institute of Heath Technology, Suzhou Gaobo Vocational College, Qingshan Road, Suzhou Science and Technology Tower, Hi-Tech Area, Suzhou, China. He is the director of Institute of Heath Technology, Global Institute of Software technology. He has published more than 250 research papers and edited books Autophagy: Biology and Disease and Cobra Venom-Basic Research and Clinic Applications. He also contributed to 10 other books as an author.
Chapter 1 Overview of nicotinamide coenzymes.- Chapter 2 Niacin deficiency and discovery of Vitamin B3 as a precursor of the nicotinamide coenzymes.- Chapter 3 Identification, source and intracellular distribution of nicotinamide coenzyme I.- Chapter 4 Overview of nicotinamide adenine dinucleotide.- Chapter 5.- The synthesis and degradation of NAD+ and methods for enhancing NAD+ levels.- Chapter 6 The role of nicotinamide phosphoribosyl transferase in NAD+ synthesis.- Chapter 7 Methods for coenzyme I assessment.- Chapter 8 Sources and cellular distribution of coenzyme II.- Chapter 9 Physiological functions of nicotinamide coenzyme II.- Chapter 10 Anabolism and catabolism of coenzyme II.- Chapter 11 Methods for increasing coenzyme II.- Chapter 12 The function of TIGAR and the synthesis of coenzyme II.- Chapter 13 The role of glucose 6-phosphate dehydrogenase in generating coenzyme II.- Chapter 14 Methods for coenzyme II assessment.- Chapter 15 Interconversion of coenzyme I and II, trans-organelle transport and its significance.- Chapter 16 Physiological role of nicotinamide coenzyme I in cellular metabolism.- Chapter 17 Nicotinamide adenine dinucleotide and signaling transduction.- Chapter 18 Nicotinamide adenine dinucleotide and immunoregulation.- Chapter 19 Coenzyme I and biological rhythm.- Chapter 20 Nicotinamide coenzyme II and free radical metabolism and homeostasis.- Chapter 21 Nicotinamide coenzyme II and reductive synthesis, biotransformation, and protein interactions.- Chapter 22 NADPH and purinergic signal transduction.- Chapter 23 Nicotinamide adenine dinucleotide and heart disease.-Chapter 24 Nicotinamide adenine dinucleotide in lipid metabolism and atherosclerosis.- Chapter 25 Nicotinamide adenine dinucleotide and ischemic stroke.- Chapter 26 Nicotinamide adenine dinucleotide and its precursors in hemorrhagic stroke.-Chapter 27 Nicotinamide coenzymes and metabolic diseases.- Chapter 28 Nicotinamide adenine dinucleotide and Aging.-Chapter 29 Coenzyme I and intestinal diseases.-Chapter 30 Coenzyme I and skeletal muscle disorders.- Chapter 31 Coenzyme I and chronic fatigue syndrome.- Chapter 32 Coenzyme I and depression.- Chapter 33 The role of NAD+-dependent signal mechanisms in cancer development and treatment.- Chapter 34 Nicotinamide adenine dinucleotide and Alzheimer disease.- Chapter 35 Nicotinamide adenine dinucleotide and Parkinson disease.- Chapter 36 Coenzyme II and aging.- Chapter 37 Coenzyme II and heart disease.- Chapter 38 Coenzyme II and vascular endothelium and blood-brain barrier.- Chapter 39 NADPH and Alzheimer's disease and Parkinson disease.-Chapter 40 Coenzyme II and ischemic stroke.- Chapter 41 NADPH and neuroinflammation.- Chapter 42 Nicotinamide coenzyme II and neuroexcitotoxicity.- Chapter 43 Inhibition of platelet aggregation and thrombosis by nicotinamide coenzymes.- Chapter 44 Research on the production technology of nicotinamide coenzymes and their precursors.- Chapter 45 Methods for industrial scale preparation and purification of nicotinamide coenzymes and their precursors.- Chapter 46 The application of the nicotinamide coenzymes and precursors.- Chapter 47 The application of nicotinamide coenzyme precursors in health food.- Chapter 48 Coenzyme I Drug.
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