List of abbreviations

2D Two-dimensional 3D Three-dimensional 5-FU 5-Fluorouracil A1AT a1 Antitrypsin ADME Tox Absorption, distribution, metabolism, excretion and toxicity ALI Air-liquid interface ASC Adipose-derived stem cells ATP Adenosine-5'-triphosphate ATRA All trans-retinoic acid BBB Blood-brain barrier bFGF Basic fibroblast growth factor BME Basement membrane extracts BNDF Brain-derived neurotrophic factor CAF Cancer-associated fibroblast CD Cytochalasin D; cluster of differentiation CDI 1,1'-Carbonyldiimidazole CDM-HD Chemically defined medium for high-density cell culture C/EBPa CCAAT-enhancer-binding proteins CHO Chinese hamster ovary CLL Chronic lymphocytic leukaemia CNS Central nervous system CP Cortical plate CTG CellTracker green; CellTiter-Glo CV Coefficient of variation CYP1A1 Cytochrome P450, family 1, subfamily A, polypeptide 1 CYP2E1 Cytochrome P450 2E1 CYP3A4 Cytochrome P450 3A4 d4T 2´,3´-Didehydro-3´deoxythymidine DNA Deoxyribonucleic acid DCIS Ductal carcinoma in situ DLS Dynamic light scattering DMEM Dulbecco's modified eagle medium DMSO Dimethyl sulfoxide DNP Dinitrophenol DOX Doxorubicin DPMK Drug metabolism and pharmacokinetics DRG Dorsal root ganglia DTT Dithiothreitol EthD Ethidium homodimer-1 EB Embryoid body ECM Extracellular matrix ECS Extracapillary space EDTA Ethylenediamine tetra-acetic acid EEF1 Elongation factor 1 complex EFP Evoked field potential EGF Epidermal growth factor EGFR Epidermal growth factor receptor EHS Engelbreth-Holm-Swarm EHT Engineered heart tissue ELISA Enzyme-linked immunosorbent assay EMT Epithelial-mesenchymal transition ESC Embryonic stem cell ET Engineered tissue EVS Extravascular space FA Focal adhesion FACS Fluorescence activated cell sorting FBS Fetal bovine serum FDA Food and Drug Administration; fluorescein diacetate GABA ?-Aminobutyric acid GAG Glycosaminoglycan GFAP Glial fibrillary acid protein GFP Green fluorescent protein GMP Good Manufacturing Practice GSH Glutathione synthase GSSG Oxidised glutathione HA Hyaluronic acid HARV High aspect ratio vessel HCA High-content analysis HCV Hepatitis C virus HCVpp Hepatitis C virus pseudoparticles HD Hanging drop HDMEC Human dermal microvascular endothelial cell HDP Hanging drop plate H&E Haematoxylin and eosin HF Hollow fibre HFBR Hollow fibre bioreactor HFIM Hollow fibre infection model HIPE High internal phase emulsion HiPSC Human induced pluripotent stem cell HIV Human immunodeficiency virus HMEC Human microvascular endothelial cell hMSC Human mesenchymal stem cell HNF4a Hepatocyte nuclear factor 4 a HPC Hydroxypropylcellulose HSC Haematopoietic stem cell HS Heparan sulfate HTS High-throughput screening HUVEC Human umbilical vein endothelial cell ICM Inner cell mass ID Internal diameter IDC Invasive ductal carcinoma IgG Immunoglobulin G iPSC Induced pluripotent stem cell LC-MS Liquid chromatography-mass spectrometry LCST Liquid crystal solution temperature LDH Lactate dehydrogenase NF Neurofilament M-dPEG-NHS Maleimide-dPEG8-N-hydroxysuccinimide ester Mal-PVA Maleimide-functionalised polyvinyl alcohol MAP Microtubule-associated protein MCR Multicellular...