Developmental Origins of Health and Disease

Section I. Overview: 1. Overview and introduction to the 2nd edition of the developmental origins of health and disease (DOHaD) Lucilla Poston, Keith M. Godfrey, Sir Peter D. Gluckman and Mark A. Hanson; Section II. Exposures driving long-term DOHaD effects: 2. The evolutionary basis of DOHaD Felicia M Low, Peter D Gluckman and Mark A Hanson; 3. Timing: Critical DOHaD windows with lifelong effects Keith M. Godfrey, Tom Fleming, Mary Barker, Judith Stephenson, Mark Vickers, Frank Bloomfield and Rachael Taylor; 4. Long-term effects of food insecurity and undernutrition in early life Sophie E. Moore; 5. Short and long-term effects of maternal obesity and dysglycaemia for women and their children Jodie M. Dodd, Amanda J Poprzeczny, Andrea R. Duessen and Jennie Louise; 6. Long-term DOHaD effects of prenatal maternal stress and mental health Matthias Schwab and Florian Rakers; 7. Environmental exposures in early life: effects of air pollution, chemicals and climate change on human health and wellbeing Kirsten R. Poore, Marie Pedersen and Sibylle Ermler; 8. Developmental programming and the microbiome: How the maternal environment and early life shapes the infant gut microbiome pathway(s) and risk of disease Kameron Y. Sugino and Jacob E. Friedman; 9. Exposures driving long-term effects of DOHaD effects: Influence of assisted reproductive technologies Daniel R. Brison, John C. M. Dumoulin, Hannah L. Morgan, Tessa J. Roseboom and Adam J. Watkins; Section III. Outcomes: 10. Cardiometabolic and renal DOHaD outcomes in offspring of complicated pregnancy Dino A. Giussani, Rebecca M. Reynolds, Paul Leeson, Karen M. Moritz, John F. Bertram and Susan E. Ozanne; 11. Development origins of chronic respiratory diseases Liesbeth Duijts, Annemiek Mian, Tarik Karramass and Vincent W. V. Jaddoe; 12. Early life adversity and female reproductive outcomes: How growth, diet and nutrition impact reproductive function and accelerated reproductive ageing Patrycja A. Jazwiec and Deborah M. Sloboda; 13. Developmental programming of ageing induced by poor maternal nutrition; evidence from rodent studies Elena Zambrano and Peter W. Nathanielsz; Section IV. Mechanisms: 14. Visualizing structural underpinnings of DOHaD Kent L. Thornburg, John Bertram, Jacob E. Friedman, David Hill, Kevin Kolahi and Christopher Kroenke; 15. Molecular and epigenetic mechanisms of DOHaD Richard Saffery, Amanda Vlahos and Toby Mansell; 16. The role of the placenta in DOHaD Rohan M. Lewis and Amanda N. Sferruzzi-Perri; Section V. Interventions: 17. Interventions to prevent DOHaD effects in pregnancy Lucilla Poston; 18. Interventions to prevent DOHaD effects in infancy and early childhood Bartlomiej Mateusz Zalewski, Bernadeta Patro-Golab, Barbara Bozek, M. Kolodziej, Kathryn V. Dalrymple, Lucilla Poston and Hania Szajewska; Section VI. Public health and policy implications of interventions; 19. Education and science communication: Translation of DOHaD evidence for health benefit Jacquie L. Bay and Suzanne Trask; 20. DOHaD - engaging with new global issues to inform policy Peter D. Gluckman and Mark A. Hanson.