It is less than 80 years since John Newport Langley first proposed the role of "receptive substances" as the site of drug action from his obser vations on the effects of nicotine and curare at the myoneural junction. The many advances in our understanding of receptor biology that have occurred during the intervening period mirror the extraordinary growth of knowledge in the biological sciences and in cell and molecular biology in particular. Receptor biology, in common with many other topics in contemporary biology, is on the threshold of a transition from being a descriptive, phenomenological discipline to one in which underlying mechanisms and regulatory principles can be defined with increasing pre cision. This change, together with the evolution of powerful analytical techniques and timely convergence of ideas from a number of previously separate fields of inquiry, is generating an increasingly unified theoretical and experimental framework for the study of receptor function. These themes, and the mood of anticipation that a real understanding of receptor function in health and disease is emerging, are reflected in in this volume, which summarizes the proceedings of the Sec the papers ond Smith Kline & French Research Symposium on New Horizons in Therapeutics held in Philadelphia in 1984.
Reihe
Sprache
Verlagsort
Verlagsgruppe
Illustrationen
13 s/w Abbildungen
XXVI, 458 p. 13 illus.
Dateigröße
ISBN-13
978-1-4613-2131-6 (9781461321316)
DOI
10.1007/978-1-4613-2131-6
Schweitzer Klassifikation
1 Receptor Regulation: Problems and Perspectives.- 2 Patterns in Receptor Behavior and Function.- 3 The Membrane Receptors of Epidermal Growth Factor: Structural and Functional Studies.- 4 The Insulin Receptor as a Tyrosine-Specific Protein Kinase.- 5 Signal Transduction in Biological Membranes.- 6 Receptor-Controlled Phosphatidylinositol 4,5-Bisphosphate Hydrolysis in the Control of Rapid Receptor-Mediated Cellular Responses and of Cellular Proliferation.- 7 Requirements for Steroid Hormone Action in Eucaryotic Cells.- 8 Inositol Trisphosphate and Diacylglycerol as Intracellular Second Messengers.- 9 Ionic Signal Transduction by Growth Factors.- 10 Guanine-Nucleotide-Binding Regulatory Proteins: Membrane-Bound Information Transducers.- 11 Role of Cyclic-AMP-Dependent Protein Kinase in the Regulation of Cellular Processes.- 12 The Homogeneity and Discreteness of Membrane Domains.- 13 Internalization and Processing of Peptide Hormone Receptors.- 14 Sorting and Recycling of Cell Surface Receptors and Endocytosed Ligands: The Asialoglycoprotein and Transferrin Receptors.- 15 The Nicotinic Acetylcholine Receptor: Its Structure, Multiple Binding Sites, and Cation Transport Properties.- 16 Adenylate-Cyclase-Coupled (3-Adrenergic Receptors: Biochemical Mechanisms of Desensitization.- 17 Control of Receptor Function by Homologous and Heterologous Ligands.- 18 Ligand-Receptor Interactions at the Cell Surface.- 19 Unique Tumor-Specific Antigens as Altered Cell-Surface Receptors.- 20 Mechanisms That Regulate Membrane Growth Factor Receptors.
