Antidepressants and Receptor Function

Name: Antidepressants and Receptor Function
Brand: Wiley
Price: 121.99 EUR
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Ruth Porter Gregory R. Bock Sarah Clark(Herausgeber*in)

Wiley (Verlag)

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Erschienen am 30. April 2008

304 Seiten

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Beschreibung

Ciba Foundation Symposium 123 Antidepressants and Receptor Function
Chairman: Dennis Murphy, 1986
Depression is a common and often debilitating affective disorder. Attempts to develop effective antidepressants have a long history, but many questions remain about the mechanisms of action of such treatments and about the aetiology and pathophysiology of depression itself. Early observations centred attention on central monoamine systems, and animal studies suggested that changes in beta-adrenoceptor responsiveness were a common effect of antidepressant therapies. More recent research has encompassed many different central and peripheral receptors, time-dependent adaptational events at synapses, and the functional significance of changes in neurotransmitter systems in both humans and experimental animals. Such pharmacological studies aimed ultimately at elucidating the neurochemical basis of depression and of promoting new therapeutic approaches, provide the focus of this symposium volume. Many different methods of investigating the links between monoamine systems, depression and antidepressant treatments are described. Recent studies of receptors and of monoamine uptake sites in the brain and the periphery (e.g. in platelets and fibroblasts) are reviewed, with emphasis on alpha and beta adrenoceptors, [³H]imipramine-binding sites and serotonin receptors. The results of monitoring amine metabolites in cerebrospinal fluid and of measuring neuroendocrine, physiological and behavioural responses to pharmacological challenge are presented, providing information on monoaminergic function in depressed patients and experimental animals before, during and after treatment with antidepressant drugs or electroconvulsive shock. Genetic influences on receptor density are also discussed, as is the relevance to human depressive illness of animal models, including stress-induced behavioural depression in rats and responses to social stressors in rhesus monkeys.
This book should be of interest to neuropharmacologists, psychopharmacologists, clinical pharmacologists, behavioural scientists, psychiatrists and neuroscientists.

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Symposium on Depression, antidepressants and receptor sensitivity,held at the Ciba Foundation, London, 19-21 November 1985
Editors: Ruth Porter, Gregory Bock (Organizer) and SarahClark
D. Murphy Introduction
S.Z. Langer, A.M. Galzin, C.R. Lee and H. SchoemakerAntidepressant-binding sites in brain and platelets
Discussion
W.H. Berrettini, J. Bardakjian, A.L. Barnett Jr, J.I. NurnbergerJr and E.S. Gershon beta-Adrenoceptor function in human adultskin fibroblasts: a study of manic-depressive illness
Discussion
P. Propping, W. Friedl, J. Hebebrand and K-U. Lentes Geneticstudies at the receptor level: investigations in human twins andexperimental animals
Discussion
M. Åsberg and A. Wägner Biochemical effects ofantidepressant treatment--studies of monoamine metabolites incerebrospinal fluid and platelet [³H]imipraminebinding
Discussion
R.W. Horton, C.L.E. Katona, A.E. Theodorou, A.S. Hale, S.L.Davies, C. Tunnicliffe, Y. Yamaguchi, E.S. Paykel and J.S. KellyPlatelet radioligand binding and neuroendocrine challenge tests indepression
Discussion
D.L. Murphy, C.S. Aulakh and N. A. Garrick How antidepressantswork: cautionary conclusions based on clinical and laboratorystudies of the longer-term consequences of monoamineoxidase-inhibiting antidepressants
Discussion
S.A. Checkley, T.H. Corn, I.B. Glass, C. Thompson, C. Franey andJ. Arendt Neuroendocrine and other studies of the mechanism ofantidepressant action of desipramine
Discussion
L.J. Siever, E.F. Coccaro, E. Benjamin, K. Rubinstein and K.L.Davis Adrenergic and serotonergic receptor responsiveness indepression
Discussion
General discussion I
A. Frazer, G. Ordway, J. O'Donnell, P. Vos and B. WolfeEffect of repeated administration of clenbuterol on the regulationof beta-adrenoceptors in the central nervous system of therat
Discussion
J.M. Weiss and P.G. Simson Depression in an animal model: focuson the locus ceruleus
Discussion
G.W. Kraemer Causes of changes in brain noradrenaline systemsand later effects on responses to social stressors in rhesusmonkeys: the cascade hypothesis
Discussion
J. Vetulani, L. Antkiewicz-Michaluk, A. Rokosz-Pelc and J.Michaluk Effects of chronically administered antidepressants andelectroconvulsive treatment on cerebral neurotransmitter receptorsin rodents with 'model depression'
Discussion
A.R. Green, D.J. Heal and G.M. Goodwin The effects ofelectroconvulsive therapy and antidepressant drugs on monoaminereceptors in rodent brain--similarities and differences
Discussion
General discussion II
Closing remarks
Index of contributors
Subject index

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