The AH Receptor in Biology and Toxicology

Name: The AH Receptor in Biology and Toxicology
Brand: Wiley
Price: 150.99 EUR
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Raimo Pohjanvirta(Autor*in)

Wiley (Verlag)

Erschienen am 1. Dezember 2011

432 Seiten

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978-1-118-14054-3 (ISBN)

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The AH Receptor in Biology and Toxicology
CONTENTS
PREFACE
CONTRIBUTORS
PART I: HISTORICAL BACKGROUND
1 History of Research on the AHR
PART II: AHR AS A LIGAND-ACTIVATED TRANSCRIPTION FACTOR
2 Overview of AHR Functional Domains and the Classical AHR Signaling Pathway: Induction of Drug Metabolizing Enzymes
3 Role of Chaperone Proteins in AHR Function
4 AHR Ligands: Promiscuity in Binding and Diversity in Response
5 Dioxin Response Elements and Regulation of Gene Transcription
6 The AHR/ARNT Dimer and Transcriptional Coactivators
7 Regulation of AHR Activity by the AHR Repressor (AHRR)
8 Influence of HIF1a and Nrf2 Signaling on AHR-Mediated Gene Expression, Toxicity, and Biological Functions
9 Functional Interactions of AHR with Other Receptors
10 The E3 Ubiquitin Ligase Activity of Transcription Factor AHR Permits Nongenomic Regulation of Biological Pathways
11 Epigenetic Mechanisms in AHR Function
PART III: AHR AS A MEDIATOR OF XENOBIOTIC TOXICITIES: DIOXINS AS A KEY EXAMPLE
12 Role of the AHR and its Structure in TCDD Toxicity
13 Nongenomic Route of Action of TCDD: Identity, Characteristics, and Toxicological Significance
14 Interspecies Heterogeneity in the Hepatic Transcriptomic Response to AHR Activation by Dioxin
15 Dioxin-activated AHR: Toxic Responses and the Induction of Oxidative Stress
16 Dioxin Activated AHR and Cancer in Laboratory Animals
17 Teratogenic Impact of Dioxin Activated AHR in Laboratory Animals
18 The Developmental Toxicity of Dioxin to the Developing Male Reproductive System in the Rat: Relevance of the AHR for Risk Assessment
19 TCDD, AHR, and Immune Regulation
20 Effects of Dioxins on Teeth and Bone: The Role of AHR
21 Impacts of Dioxin-Activated AHR Signaling in Fish and Birds
22 Adverse Health Outcomes Caused By Dioxin-Activated AHR in Humans
23 The Toxic Equivalency Principle and its Application in Dioxin Risk Assessment
24 AHR-active Compounds in the Human Diet
25 Modulation of AHR Function by Heavy Metals and Disease States
26 Transgenic Mice with a Constitutively Active AHR: A Model for Human Exposure to Dioxin and Other AHR Ligands
PART IV: AHR AS A PHYSIOLOGICAL REGULATOR
27 Structural and Functional Diversification of AHRs During Metazoan Evolution
28 Invertebrate AHR Homologs: Ancestral Functions in Sensory Systems
29 Role of AHR in the Development of the Liver and Blood Vessels
30 Involvement of the AHR in Cardiac Function and Regulation of Blood Pressure
31 Involvement of the AHR in Development and Functioning of the Female and Male Reproductive Systems
32 The AHR in the Control of Cell Cycle and Apoptosis
33 The AHR Regulates Cell Adhesion and Migration by Interacting with Oncogene and Growth Factor-Dependent Signaling
34 The Physiological Role of AHR in the Mouse Immune System
35 AHR and the Circadian Clock
INDEX
COLOUR PLATES

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