Biopharmaceutical Manufacturing

Part I: Manufacturing of Recombinant Therapeutic Proteins.- Chapter 1. Single-Use Systems in Biopharmaceutical Manufacture: State of the Art and Recent Trends (Jossen et al.).- Chapter 2. Recent Developments in Bioprocess Monitoring Systems (Rahmatnejad et al.).- Chapter 3. Advances in Characterization of Industrial Bioreactors for Cell Culture Process (Fitschen et al.).- Chapter 4. Continuous Bioprocessing for Upstream Process - Perfusion Process (Chotteau et al.).- Chapter 5. Continuous Bioprocessing for Downstream (Gerstweiler).- Chapter 6. Towards Digital Twin for Biopharmaceutical Processes: Concept and Progress (Ding et al.).- Chapter 7. Integrated Process and Supply Chain Design and Optimization (Triantafyllou et al.).- Chapter 8. Production of Complex Proteins in Plants - From Farming to Manufacturing (Nausch et al.).- Chapter 9. Manufacturing of Recombinant Proteins Using Quality by Design (QbD) Methodology: Current Trend and Challenges (Shin and Landauer).- Chapter 10. Biopharma 4.0 for Biologics Manufacturing Under Pandemic Constraints (Schmidt et al.).- Chapter 11. Biopharma 4.0: Digital Technologies Driving Smart Manufacturing (Nargund et al.).- Part II: Manufacturing Aspects of Cell and Gene Therapy .- Chapter 12. Essential Aspects of Mesenchymal Stem Cell Manufacturing (Fleischhammer et al.).- Chapter 13. Towards a Continuous Production of Human Mesenchymal Stromal Cells in a Chemically Defined Medium: Opportunities and Challenges for a Robust and Scalable Expansion Process (Tasto and Salzig).- Chapter 14. Biomanufacturing Aspects of Gene Therapy (Warnock).- Chapter 15. Manufacturing and Quality of Advanced Therapeutics: Cellular Therapies, CAR-T and Gene Therapies (van den Bos et al.).