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Editor-in-Chief:
Daniel K. Podolsky, M.D. President, Professor of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
Associate Editors:Michael Camilleri, M.D, Professor of Medicine and Physiology, College of Medicine, Mayo Clinic; Consultant in Gastroenterology, Mayo Clinic, Rochester.
J. Gregory Fitz, M.D, Dean, Southwestern Medical School, Distinguished Chair in Medical Science, UT Southwestern Medical Center, Dallas, TX, USA.
Anthony N. Kalloo, M.D, Professor of Gastroenterology and Director, Division of Gastroenterology and Hepatology, The Johns Hopkins Hospital, Baltimore, MD USA.
Fergus Shanahan, M.D, Professor and Chair, Department of Medicine and Director, Alimentary Pharmabiotic Centre, University College Cork, Cork University Hospital, Ireland.
Timothy C. Wang, M.D, Chief, Division of Digestive and Liver Diseases, Silberberg Professor Medicine, Department of Medicine and Irving Cancer Research Center, Columbia University Medical Center, New York, NY USA.
Contributors
Preface
Foreword by Tadataka Yamada
About the companion website and companion digital edition
VOLUME ONE
PART 1, Anatomy and development
1 Development and diff erentiation of the gastrointestinal systemBen Z. Stanger and Daniel K. Podolsky
2 Stem cells and tissue renewalJohan H. van Es, Sina Bartfeld, and Hans Clevers
3 Esophagus: anatomy and structural anomaliesIkuo Hirano
4 Stomach and duodenum: anatomy and structural anomaliesEric Goldberg and Jean-Pierre Raufman
5 Small intestine: anatomy and structural anomaliesDeborah C. Rubin and Anisa Shaker
6 Colon: anatomy and structural anomaliesKonstantin Umanskiy and Jeffrey B. Matthews
7 Pancreas: anatomy and structural anomaliesKevin Tri Nguyen and Diane M. Simeone
8 Abdominal cavity: anatomy, structural anomalies, and herniasKevin P. Murphy, Michael M. Maher, and Owen J. O'Connor
9 Gallbladder and biliary tract: anatomy and structural anomaliesTheodore H. Welling
10 Liver: anatomy, microscopic structure, and cell typesGary C. Kanel
11 Gastrointestinal blood flowThörsten Vowinkel and D. Neil Granger
PART 2, Mechanisms of normal and abnormal gastrointestinal function
A Components
12 Integrative responses of the gastrointestinal tract, pancreas, and liver to a mealStephen J. Pandol, Helen E. Raybould, and Hal Yee
13 Gastrointestinal hormones and receptorsLaurence J. Miller
14 The brain-gut axisAdam D. Farmer and Qasim Aziz
15 The innervation of the gastrointestinal tractJohn B. Furness, Daniel P. Poole, Hyun-Jung Cho, Brid P. Callaghan, and Leni R. Rivera
16 Smooth muscle of the gutGabriel M. Makhlouf and Karnam S. Murthy
17 The mucosal immune system and gastrointestinal inflammationFabio Cominelli, Kristen O. Arseneau, Matthew J. Hamilton, and Richard S. Blumberg
18 Epithelia and gastrointestinal functionJerrold R. Turner
B Motility
19 Esophageal motor functionPeter J. Kahrilas, John E. Pandolfino, and David A. Katzka
20 Gastric motility and gastric emptyingMichael Camilleri
21 Motility of the small intestine and colonAdil E. Bharucha and William Lee Hasler
22 Motility of the biliary tractGary M. Mawe, Brigitte Lavoie, Peter L. Moses, and Maria J. Pozo
C Secretion and absorption
23 Gastric secretionsM. Michael Wolfe and Robert C. Lowe
24 Electrolyte secretion and absorption in the small intestine and colonKim E. Barrett and Stephen J. Keely
25 Pancreatic secretionChung Owyang and John A. Williams
26 Bile secretion and cholestasisAndrew P. Feranchak
D Nutrition
27 General nutritional principlesDavid H. Alpers and Kevin D. Cashman
28 Control of appetite/satiety and energy balanceJoel K. Elmquist and Jay D. Horton
29 Nutrient digestion, absorption, and sensingShrinivas Bishu and Eamonn M.M. Quigley
30 Vitamins and mineralsFrancis C. Okeke, Danielle Flug Capalino, Laura E. Matarese, and Gerard E. Mullin
E Miscellaneous
31 Neoplasia of the gastrointestinal tractOfer Margalit and Raymond N. DuBois
32 The human intestinal microbiota and microbiomeOmry Koren and Ruth E. Ley
33 Drug metabolism, transport, and pharmacogenomicsKristina K. Wolf, Brandon T. Gufford, Scott J. Brantley, Paul B. Watkins, and Mary F. Paine
PART 3, Principles of clinical gastroenterology
34 Clinical decision makingJasmine K. Zia and John M. Inadomi
35 Approach to the patient with dyspepsia and related functional gastrointestinal complaintsJan F. Tack
36 Approach to the patient with dysphagia, odynophagia, or noncardiac chest painAndré J.P.M. Smout
37 Approach to the patient with unintentional weight lossSreedhar Subramanian and Jonathan M. Rhodes
38 Approach to the patient with nausea and vomitingWilliam Lee Hasler
39 Approach to the patient with abdominal painPankaj J. Pasricha
40 Approach to the patient with gas and bloatingSatish S.C. Rao and Yeong Yeh Lee
41 Approach to the patient with diarrheaGail A. Hecht, Jonathan Gaspar, and Miguel Malespin
42 Approach to the patient with constipationSatish S.C. Rao and Michael Camilleri
43 Approach to the patient with acute abdomenCourtney B. Sherman and Kenneth McQuaid
44 Approach to the patient with gastrointestinal bleedingKevin A. Ghassemi and Dennis M. Jensen
45 Approach to the patient with abnormal liver chemistries or jaundiceJ. Gregory Fitz
46 Approach to gastrointestinal and liver diseases in pregnancySumona Saha and Nancy Reau
47 Genetic counselling for gastrointestinal patientsLaura E. Panos and C. Richard Boland
PART 4, Gastrointestinal diseases
A Esophagus
48 Motility disorders of the esophagusJohn E. Pandolfi no and Peter J. Kahrilas
49 Gastroesophageal reflux diseaseSabine Roman, John E. Pandolfino, and Peter J. Kahrilas
50 Eosinophilic esophagitisYael Haberman Ziv, Margaret H. Collins, and Marc E. Rothenberg
51 Esophageal infections and disorders associated with acquired immunodeficiency syndromeC. Mel Wilcox
52 Barrett esophagus and esophageal adenocarcinomaStuart Jon Spechler, David H. Wang, and Rhonda F. Souza
53 Esophageal squamous cell carcinomas and other neoplasmsAdam J. Bass and Anil K. Rustgi
54 Miscellaneous diseases of the esophagus: foreign bodies, physical injury, and systemic and dermatological diseasesSeth D. Crockett, Evan S. Dellon, and Nicholas J. Shaheen
B Stomach
55 Disorders of gastric emptyingHenry P. Parkman
56 Peptic ulcer diseaseRichard J.M. Ingram, Krish Ragunath, and John C. Atherton
57 Zollinger-Ellison syndromeRobert T. Jensen
58 Gastritis and gastropathyMary Kay Washington and Richard M. Peek Jr.
59 Tumors of the stomachEmad M. El-Omar and Mairi H. McLean
60 Miscellaneous diseases of the stomachTamas A. Gonda and Yanghee Woo
C Small intestine
61 Dysmotility of the small intestine and colonLawrence Szarka
62 Bacterial, viral, and toxic causes of diarrhea, gastroenteritis, and anorectal infectionsMitchell B. Cohen
63 Chronic infections of the small intestineBilly Bourke and Séamus Hussey
64 Celiac diseaseDaniel A. Leffl er, Melinda Dennis, and Ciarán P. Kelly
65 Disorders of epithelial transport, metabolism, and digestion in the small intestineSushila R. Dalal and Eugene B. Chang
66 Bacterial overgrowthEamonn M.M. Quigley
67 Short bowel syndrome and small bowel transplantationJohn K. DiBaise and Debra Sudan
68 Tumors of the small intestineMaria Rosario Ferreira and Barbara H. Jung
69 Miscellaneous diseases of the small intestineMarc S. Levin
D Inflammatory bowel disease
70 Inflammatory bowel diseases: pathogenesisAshwin N. Ananthakrishnan, Ramnik J. Xavier, and Daniel K. Podolsky
71 Ulcerative colitisStephen B. Hanauer and Daniel K. Podolsky
72 Crohn's disease: clinical manifestations and managementGil Y. Melmed and Stephan R. Targan
73 Surgical treatment of inflammatory bowel diseaseAlessandro Fichera, Emily Finlayson, Leon Maggiori, and Fabrizio Michelassi
74 Microscopic colitis and other miscellaneous inflammatory and structural disorders of the colonEugene F. Yen and Darrell S. Pardi
E Colon
75 Irritable bowel syndromeElizabeth J. Videlock and Lin Chang
76 Diverticular disease of the colonDavid J. Humes and Robin C. Spiller
Index
VOLUME TWO
77 Polyps of the colon and rectumJohn J. Garber III and Daniel C. Chung
78 Malignant tumors of the colonJay Luther and Andrew T. Chan
79 Polyposis syndromesRandall W. Burt and Kory W. Jasperson
80 Colorectal cancer screeningUri Ladabaum
81 Anorectal diseasesAdil E. Bharucha and Arnold Wald
F Pancreas
82 Acute pancreatitisHana Algül, Andreas Weber, Wolfgang Huber, and Roland M. Schmid II
83 Autoimmune pancreatitisPhil A. Hart and Suresh T. Chari
84 Chronic pancreatitisJoachim Mössner, Albrecht Hoff meister, and Julia Mayerle
85 Hereditary diseases of the pancreasDavid C. Whitcomb
86 Cystic lesions of the pancreasJames J. Farrell
87 Adenocarcinoma of the pancreasPaul T. Fanta and Andrew M. Lowy
88 Neuroendocrine tumors of the pancreasPeter J. Carolan and Daniel C. Chung
G Gallbladder and biliary tract
89 GallstonesPiero Portincasa and David Q.-H. Wang
90 Primary sclerosing cholangitisJayant A. Talwalkar and Konstantinos N. Lazaridis
91 Cystic diseases of the liver and biliary tractJames Buxbaum and Shelly C. Lu
92 Tumors of the biliary tractTushar Patel
93 Sphincter of Oddi dysfunction and postcholecystectomy syndromeJohn O. Clarke and Anthony N. Kalloo
H Liver
94 Acute viral hepatitisMarc G. Ghany and T. Jake Liang
95 Chronic hepatitis B viral infectionKarin L. Andersson and Jules L. Dienstag
96 Hepatitis C virus infectionAndrew W. Tai and Raymond T. Chung
97 Drug-induced liver diseaseWilliam M. Lee
98 Acute liver failureWilliam M. Lee
99 Autoimmune hepatitisRichard Taubert and Michael P. Manns
100 Primary biliary cirrhosisMarlyn J. Mayo and Dwain L. Thiele
101 HemochromatosisPaul C. Adams
102 Metabolic diseases of the liverShikha S. Sundaram and Ronald J. Sokol
103 Alcoholic liver diseaseJose Altamirano, Eric S. Orman, and Ramon Bataller
104 Nonalcoholic fatty liver diseaseM. Shadab Siddiqui and Arun J. Sanyal
105 Hepatic fi brosis and cirrhosisDon C. Rockey
106 Ascites and its complicationsGuadalupe Garcia-Tsao
107 Central nervous system and pulmonary complications of end-stage liver diseaseScott C. Matherly and Jasmohan S. Bajaj
108 Liver transplantationAlyson N. Fox and Robert S. Brown Jr.
109 Hepatocellular carcinomaAmit Singal and Jorge A. Marrero
110 Liver abscessRoman E. Perri and David S. Raiford
111 Vascular diseases of the liverSusana Seijo and Laurie D. DeLeve
I Miscellaneous
112 Intraabdominal abscesses and fistulaePeter Irving and Nyree Griffin
113 Diseases of the peritoneum, retroperitoneum, mesentery, and omentumJennifer W. Harris and B. Mark Evers
114 Nutrition supplementationJoshua D. Novak and Stephen J. D. O'Keefe
115 Obesity: treatment and complicationsLouis A. Chaptini and Steven R. Peikin
116 Bariatric surgeryObos Ekhaese and Danny O. Jacobs
117 Eating disordersHenry C. Lin and Eric E. Stone
118 Complications of HIV/AIDS and other secondary immunodeficienciesPhillip D. Smith and Edward N. Janoff
119 Immunological disorders: (a) Food allergy and hypersensitivityJonathan O'B. Hourihane
120 Immunological disorders: (b) immunodeficiencies and gastrointestinal complications of organ transplantationPaula O'Leary and Fergus Shanahan
121 Parasitic diseases: protozoaEllen Li and Samuel L. Stanley Jr.
122 Parasitic diseases: helminthsThormika Keo, John Leung, and Joel V. Weinstock
123 Gastrointestinal and hepatic manifestations of specific genetic disordersJudy H. Cho
124 Gastrointestinal manifestations of systemic diseasesEran Israeli and Charles N. Bernstein
125 Skin lesions associated with gastrointestinal and liver diseasesTravis W. Vandergriff and Kim B. Yancey
126 Oral manifestation of gastrointestinal diseasesVidyasagar Ramappa and Yashwant R. Mahida
127 Gastrointestinal vascular malformations and neoplasms: arterial, venous, arteriovenous, and capillaryAnne C. Travis and Joshua R. Korzenik
128 Intestinal ischemia and vasculitidesJuan-Ramón Malagelada and Carolina Malagelada
129 Radiation injury in the gastrointestinal tractSteven M. Cohn, Alda Vidrich, and Stephen J. Bickston
130 Complementary and alternative medicine in gastroenterologyAnthony Lembo and Andrea Bollom
PART 5, Diagnostic and therapeutic modalities in gastroenterology
A Endoscopic
131 General approach to endoscopy: sedation, monitoring, and preparationHala Fatima and Douglas K. Rex
132 Upper gastrointestinal endoscopyAbdurrahman Kadayifci and William R. Brugge
133 Capsule and small bowel endoscopyJonathan A. Leighton and Shabana F. Pasha
134 Colonoscopy and flexible sigmoidoscopyPeter H. Rubin, Steven Naymagon, Christopher B. Williams, and Jerome D. Waye
135 Endoscopic retrograde cholangiopancreatographyMustafa A. Arain and Martin L. Freeman
136 Gastrointestinal dilation and stent placementShayan Irani and Richard A. Kozarek
137 Endoscopic approaches to enteral nutritionRyan J. Law and Todd H. Baron
138 Management of upper gastrointestinal haemorrhage related to portal hypertensionTinsay A. Woreta and Zhiping Li
139 Endoscopic diagnosis and treatment of nonvariceal upper gastrointestinal hemorrhageAnne Thai and Joseph W. Leung
140 Endoscopic therapy for polyps and tumorsMouen A. Khashab and Heiko Pohl
141 Laparoscopy and laparotomyRicardo Zorron and Gustavo Carvalho
142 Submucosal endoscopyChristopher J. Gostout
143 Natural orifice translumenal endoscopic surgery (NOTES)Vivek Kumbhari and Anthony N. Kalloo
B Imaging
144 Plain and contrast radiologyMarc S. Levine and Stephen E. Rubesin
145 Abdominal sonographyStephanie F. Coquia, Linda C. Chu, and Ulrike M. Hamper
146 Endoscopic ultrasonographyMouen A. Khashab and Marcia Irene Canto
147 Computed tomography of the gastrointestinal tractSiva P. Raman, Karen M. Horton, Pamela T. Johnson, Alec J. Megibow, and Elliot K. Fishman
148 Magnetic resonance imagingDiane Bergin and Donald G. Mitchell
149 Positron emission tomographyJonathan Sham, Manuela Matesan, James Park, and Satoshi Minoshima
150 Radionuclide imaging in the gastrointestinal tractHarvey A. Ziessman
151 Abdominal angiographyKyung Jae Cho
152 Interventional radiologyTodd R. Schlachter, Julius Chapiro, Rafael Duran, Vania Tacher, Camila Zamboni, Luke Higgins, and Jean-Francois Henri Geschwind
153 Confocal laser microscopyHelmut Neumann and Ralf Kiesslich
C Pathology
154 Liver biopsy and histopathological diagnosisSugantha Govindarajan and Maurizio Bonacini
155 Endoscopic mucosal biopsy - histopathological interpretationElizabeth A. Montgomery and Anthony N. Kalloo
D Gastrointestinal function studies
156 Tests of gastric and pancreatic function and absorptionJoseph R. Pisegna and Deepinder Goyal
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