Survey and Summary A Nomenclature for Restriction Enzymes, DNA Methyltransferases, Homing Endonucleases and Their Genes.- Restriction-Modification Systems as Minimal Forms of Life.- Molecular Phylogenetics of Restriction Endonucleases.- Sliding or Hopping? How Restriction Enzymes Find Their Way on DNA.- The Type I and III Restriction Endonucleases: Structural Elements in Molecular Motors that Process DNA.- The Integration of Recognition and Cleavage: X-Ray Structures of Pre-Transition State Complex, Post-Reactive Complex and the DNA-Free Endonuclease.- Structure and Function of EcoRV Endonuclease.- Two of a Kind: BamHI and Bg1II.- Structure and Function of the Tetrameric Restriction Enzymes.- Structure and Function of Type IIE Restriction Endonucleases - or: From a Plasmid that Restricts Phage Replication to a New Molecular DNA Recognition Mechanism.- Analysis of Type II Restriction Endonucleases That Interact with Two Recognition Sites.- The Role of Water in the EcoRI-DNA Binding.- Role of Metal Ions in Promoting DNA Binding and Cleavage by Restriction Endonucleases.- Restriction Endonudeases: Structure of the Conserved Catalytic Core and the Role of Metal Ions in DNA Cleavage.- Protein Engineering of Restriction Enzymes.- Engineering and Applications of Chimeric Nucleases.
