Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry.
This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth.
- Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease
- Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins
- Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery
- Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS)
- Features chapter contributions from international leaders in the field
Auflage
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
Illustrationen
Approx. 400 illustrations (200 in full color)
Dateigröße
ISBN-13
978-0-12-823578-2 (9780128235782)
Schweitzer Klassifikation
Part 1: General Aspects of Epigenetics in Psychiatry1. Introduction to Epigenetics in Psychiatry2. Outline of Epigenetics3. A Brief History of Epigenetics in Psychiatry4. Roles of Epigenetics in the Neural Stem Cell and Neuron5. Role of Epigenetics in the Brain6. Epigenetic Epidemiology of Psychiatric Disorders7. ATAC-seq and Psychiatric Disorders8. Single Cell RNA Sequencing and Psychiatric Disorders9. Single Cell Analysis and Psychiatric Disorders10. Laboratory Techniques in Psychiatric Epigenetics11. Laboratory Epigenetic Models of Schizophrenia12. Animal Models of Environmental Manipulations Resulting in Epigenetic Modifications That Increase Risk for Affective Disorders
Part 2: Epigenetics of Psychiatric Disorders13. 5-Methycytosine and 5-Hydroxymethylcytosine in Schizophrenia14. Pathogenic Histone Modifications in Schizophrenia are Targets for Therapy15. Non-Coding RNAs and Psychiatric Disorders16. Epigenetics of Bipolar Disorder17. Epigenetics in Major Depressive Disorder18. The Epigenetics of Suicide: The Critical Impact of Environment on Epigenetic Regulation in Suicide19. Epigenetics in Posttraumatic Stress Disorder20. Epigenetics and Cognitive Disorders21. Epigenetics in Intellectual Disability22. Epigenetics and Pervasive Developmental Disorders23. Epigenetics in Child Psychiatry24. Epigenetic Mechanisms of Drug Addiction Vulnerability25. Epigenetics and Addiction to Alcohol
Part 3: Epigenetics in the Therapy of Psychiatric Disorders26. Epigenetic Effects of Currently Used Psychotropic Drugs27. DNA Methyltransferase Inhibitors and Psychiatric Disorders28. Histone Deacetylase Inhibitors and Psychiatric Disorders29. Psychotherapy and Epigenetics in Psychiatry30. Gene-Specific Editing for Manipulating Specific Psychiatric Disorders
Part 4: Other Topics in Epigenetics in Psychiatry31. Nutritional Effects on Epigenetics in Psychiatry32. Systems Biology and the Epigenetics of Psychiatric disorders33. Transgenerational (Heritable) Epigenetics and Psychiatric Disorders34. Epigenetic Aspects of the Microbiome and Psychiatric Disorders
