L-Arginine in Clinical Nutrition

Section 1: Basic Processes at the Cellular Levels.- Arginine uptake by cells .- L-arginine and the expression of HSP70 and p-53 proteins .- AMP-activated protein kinase and L-arginine .- Amidine-based compounds affecting arginine metabolism .- Oxy- and sulfoanalogues of L-arginine .- Regulation of expression and activity of L-arginine transporters by nutrients and hormones: A focus in transcriptional mechanisms regulated by glucose and insulin .- Arginine, pancreatic beta cell function and diabetes: mechanisms of stimulated insulin release and pathways of metabolism .- Erythrocytes by-products of arginine catabolism .- Section 2: Arginine Metabolism and Functions.- Arginine synthesis from enteral proline .- Arginine and macrophages: role in classical and alternative activation .- Arginine and TNF alpha production in macrophages: a focus on metabolism, ageing, metabolic syndrome and type 2 diabetes .- Arginine metabolism impairment during sepsis and diseases: causes and consequences .- Use of arginine with Growth Hormone Releasing Hormone (GHRH) and the endocrine response .- Serum arginase in healthy subjects and nitric oxide .- Section 3: Arginine Status in Cells Related to Organ Damage and Disease.- Protein Arginine Methylation of RNA-binding Proteins and Their Impact on Human Diseases .- DNA-arginine adducts and implications in disease .- Homoarginine and L-arginine: Glycine amidinotransferase in stroke .- The L-arginine/asymmetric dimethylarginine (ADMA) ratio in health and disease: an overview .- Arginine and its transporters in colorectal cancer .- Arginine Uptake and Its Role in the Survival of Breast Cancer Cells .- Section 4: Arginine Status and Use in Healthy Individuals.- Arginine production during pregnancy .- L-arginine in the uterus and placenta and during gestation in mammals .- Oral L-arginine supplementation in young males: endocrinology, metabolic, and physiological responses at rest and during exercise .- Metabolic precursors of L-Arginine supplementation in sport: a focus on L-Citrulline and L-Ornithine .- Section 5: Arginine and Diseases of the Gastrointestinal Tract.- Arginine and its use in ameliorating Cryptosporidium parvum infection in undernourished children .- Arginine and Inflammatory Bowel Disease (IBD) .- Dietary L-arginine and intestinal recovery .- Enteral and parenteral arginine supplementation in intestinal ischemia and reperfusion injury .- Mucosal Protection by Arginine in the Upper Gastrointestinal Tract .- Enteral L-arginine and necrotizing enterocolitis .- Section 6: Therapeutic uses of Arginine: Diabetes, Obesity and Cardiovascular Diseases.- L-arginine usage in Type I diabetes: From the autoimmune event to human dietary supplementation .- Oral l-arginine supplementation and glucose metabolism and vascular function .- Arginine enriched apples and diabetic control .- Beneficial impact of cod protein, arginine and other amino acids on insulin sensitivity .- Obese subjects and supplemental L-arginine .- Mitochondrial cardiomyopathy and usage of L-arginine .- Arginine Measurement and Concentrations in Hypertension and other Cardiovascular Disease .- L-Arginine and cardiovascular disease .- Arginine therapy in sickle cell disease .- Section 7: Therapeutic Uses of Arginine: Cancer, Wound Healing and Infectious Disease .- Role of arginine in surgical patients with head and neck cancer .- Arginine-Incorporated Albumin Mesospheres: A Drug Delivery System for Cancer Therapy .- Use of L-arginine and glycine supplementation to reduce radiotherapy damage .- Arginine in Cancer Therapy .- Mechanisms of Arginine-Auxotrophic Response and Their Cancer Therapeutic Implications .- The role of arginine in wound healing .- L-arginine and bacterial translocation: implications for health .- L-arginine in Pulmonary Tuberculosis .- Arginine in Health and Disease: Recommended Resources and Further Reading.