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Particle Therapy (PT) is a form of external beam radiotherapy using charged particles, such as protons and carbon ions, for cancer treatment. The benefits of PT, stemming from its physical and radiobiological advantages, necessitate the use of dedicated imaging technologies and approaches to ensure precise treatment planning and delivery.
This book endeavors to establish a fundamental understanding of imaging within the context of PT, alongside exploring current research and clinical perspectives on its role. The focus is directed towards examining near-room, in-room, and in-beam technologies, both those already in clinical use and those in the developmental stage, which play pivotal roles in treatment planning, delivery, and verification processes, enabling treatment adjustments either offline or online. Concurrently, the text addresses methodological solutions derived from these imaging modalities to effectively address challenges such as range uncertainties, anatomical variations, and biological properties, thereby enhancing the accuracy of treatment modeling and adaptation.
This book would appeal to researchers, scientists and oncologists interested in particle therapy and related imaging modalities.
Chiara Paganelli, PhD, is Assistant Professor at the Department of Electronics, Information and Bioengineering at Politecnico di Milano, Milano, Italy. She obtained her PhD in Bioengineering at Politecnico di Milano in 2016. Her main research is on image-guided radiotherapy and particle therapy with a focus on MRI-guidance and personalized radiotherapy.
Chiara Gianoli, PhD, is a scientist who has been affiliated to the Ludwig-Maximilians-Universität München since October 2014 and is currently in the Habilitation program. Since November 2017, she has been principal investigator of the Deutsche Forschungsgemeinschaft project "Hybrid imaging framework in hadrontherapy for adaptive radiation therapy" at the Department of Experimental Physics - Medical Physics in the faculty for physics of the same university. Her interest is focused on imaging in medical physics, with particular reference to imaging technologies and methodologies, including approaches relying on the use of artificial intelligence, for ion beam therapy.
Antje Knopf, obtained her PhD degree in Physics in 2009 from the Ruperto Carola University Heidelberg, Germany, carrying out the related research at the Massachusetts General Hospital/Harvard Medical School in Boston, USA. Afterwards, she pursued an international academic career in medical physics with a focus on adaptive treatment approaches, image guidance, motion management and particle therapy. Since 2022, she has been a Full Professor for Medical Imaging and Medical Image Processing at the University of Applied Sciences and Arts Northwestern Switzerland.
1. Introduction2. Organ motion in PT3. Image registration4. Conventional X-ray imaging for treatment planning5. Conventional X-ray in-room imaging6. Ion imaging (proton CT/ion imaging)7. MRI in PT8. AI strategies to enable imaging for daily adaptive PT9. Modelling of intra-fraction motion10. Imaging for treatment verification11. Quantitative imaging in PT12. Imaging adopted in different PT centres13. Conclusions and future directions
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