Protein Targeting with Small Molecules

Discover the link between the latest chemical biology approachesand novel drug therapies!
Protein Targeting with Small Molecules: Chemical BiologyTechniques and Applications takes readers beyond the use ofchemical biology in basic research, providing a highly relevantlook at techniques that can address the challenges of biology anddrug design and development.
This indispensable bench companion features up-to-date coverageof advances in chemistry and assesses their impact on developingnew therapeutics, making it ideal for chemical biologists andmedicinal chemists who are developing small molecule drugs totarget proteins and treat diseases. In addition, the book examinesthe full range of complex biological systems and theirinterrelationship with chemistry, from the interaction ofbiological response modifiers with proteins to the chemical biologyof cell surface oligosaccharides.
Distinguished by an overview of chemical biology that isreinforced and clarified by detailed examples and descriptions oftechniques, Protein Targeting with Small Molecules: ChemicalBiology Techniques and Applications:
* Introduces key technologies and methods of chemical biologydesigned to detect the interactions of small molecules andproteins
* Facilitates the discovery of small molecules that bind toproteins and describes the molecules' application in theinvestigation of biological processes
* Presents timely coverage of the development of fluorescentprobes for small molecules, as well as the generation of smallmolecule ligands and inhibitors
* Reviews important techniques such as chemical genomics, targetprofiling, immobilization technology, detection methods, chemicalinhibition, and structure-based targeting
* Offers a compelling synopsis of data that underscores therecent progress made in the area of targeting proteins by smallmolecules