Mitochondrial Biology and Experimental Therapeutics

Target Mitochondria.- SECTION I-Mitochondrial Biology.- Introduction: Mitochondria: the cell furnace.- MItochondria: Where are They Coming From?.- Mitochondrial Dynamics: A journey from Mitochondrial Morphology to MItochondrial Function and Quality.- Mitochondrial ROS, Oxidative Stress.and Aging- The Mitochondrial Permeability Transition Pore.- Mitochondrial Regulation of Cell Death.- MItochondria in Liver Diseases.- Mitochondria in Liver Regeneration,Energy Metabolism, and Posthepatectomy Liver Dysfunction.- MItochondrial Remodeling in Cancer.- Mitochondria in Kidney Disease.- CNS diseases and disruption of Mitochondria.- Mitochondrial disruption in cardiovascular diseases.- .Drug-inducing Mitochondrial Toxicity.- MItochondrial DNA: Functions and Role in Acquired Diseases.- SECTION II-MItochondrial Therapeutics: From the Bench to Industry and Patient.- The Evolution of Mitochondrial Toxicity Assessment in Industry.- Designing Mitochondrial-Active Molecules: The Road to MitoQ and Beyond.- Recovering Mitochondrial Function in Patients' Fibroblasts.- Targeting Mitochondria with Sweat: Improving Mitochondrial Function with Physical Activity.- Modulation of Cell Fate by Tauroursodexycholic Acid: All Paths Lead to Mitochondria.- Pharmacological Targeting of the Mitchondrial Permeability Transition Pore.- Strategies to Preserve/Improve Mitochondrial Function in Organ Preservation Solutions.- MItochondrial Targeted Redox Active Compounds and the Astrocytemotoneuron Axis: relevance for the Treatment of Amyotrophic Lateral Sclerosis.- Targeting the Mitochondrial Genome Through a Nanocarrier and the Regulation of the Mitochondrial Gene Experssion.- Mitochoncrial Dysfunction and Chronic Disease: Treatment with Membrane Lipid Replacement and other Natural Supplements.- Development of Mitochondrial-Directed Plastoquinones.- Targeted Mitochondrial Genome Editing.- Targeting Therpeutic Nucleic Acids into Mitochondria: A Long Challenge.- Cell Permeable Peptides Targeting Mitochondria.- MItochondrial -Directed Cancer Therapy.- SkQ1: The Road from the Bench to the Market.- MItochondrial Follies: Comic.