Handbook of Epigenetics: The New Molecular and Medical Genetics, Third Edition provides a comprehensive analysis of epigenetics, from basic biology to clinical application. This new edition has been fully revised to cover the latest and evolving topics in epigenetics, with chapters updated and new chapters added on topics such as single-cell epigenetics, DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction, among other topics. Throughout this edition, greater emphasis falls on epigenomic analyses and incorporating multi-omics approaches rather than gene-specific analyses.
In addition, this edition has also been enhanced with step-by-step instructions in research methods, as well as easy-to-digest disease case studies and clinical trials that provide context and applied examples of recent advances in disease understanding and epigenetic therapeutics. These features empower researchers to reproduce the approaches and studies discussed and aid clinical translation. Live links across chapters tie in relevant external datasets and resources.
- Provides a timely and comprehensive collection of fully up-to-date coverage of epigenetics
- Covers basic epigenetic biology, research methods and technology, disease relationships and clinical medicine
- Written at a verbal and technical level that can be understood by scientists and students alike, with chapter summaries and conclusions included throughout
- Discusses exciting new topics in epigenetics, such as DNA methylation clocks in age-related diseases, transposable elements and epigenetics, X chromosome inactivation, and the epigenetics of drug addiction
- Includes step-by-step instructions in research protocols to aid reproducibility, as well as easy-to-digest disease case studies and clinical trials, providing context and applied examples of recent clinical translation
Auflage
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
Dateigröße
ISBN-13
978-0-323-91950-0 (9780323919500)
Schweitzer Klassifikation
1. Epigenetics Overview
SECTION I: Molecular Mechanisms of Epigenetics2. Mechanisms of DNA Methylation and Demethylation during Mammalian Development 3. Mechanisms of Histone Modification4. The Epigenetics of Non-coding RNA5. Prions and Prion-like Phenomena in Epigenetic Inheritance6. Higher-order Chromatin Organization in Diseases7. Polycomb-group Proteins and Epigenetic Control of Gene Activity
SECTION II: Methods in Epigenetics8. Methods for Assessing DNA Cytosine Modifications Genome-wide9. Analyses of Genome-wide Histone Modifications in the Mammalian Genome10. Techniques for Genome-wide Expression of Non-coding RNA11. Computational Epigenetics
SECTION III: Model Organisms of Epigenetics12. Epigenetics of Lower Organisms13. Drosophila Epigenetics14. Models of Mouse Epigenetic Inheritance: Classification, Mechanisms, and Experimental Strategies15. Plant Epigenomics
SECTION IV: Factors Influencing Epigenetic Changes16. Dynamic Changes in Epigenetic Modifications During Mammalian Transitions17. Epigenetic Biomarkers18. Transposable elements shaping the epigenome 19. Metabolic Regulation of DNA Methylation in Mammalian Cells20. Dietary and Metabolic Compounds Affecting Covalent Histone Modifications21. Epigenetics, Stem Cells and Cellular Differentiation 22. Regeneration Epigenetics23. Epigenetics of X-chromosome Inactivation24. Epigenetics of Memory Processes25. Transgenerational Epigenetics26. DNA Methylation Clocks in Age-related Disease
SECTION V: Evolutionary Epigenetics27. Evolution of Epigenetic Mechanisms in Plants28. Evolution of Epigenetic Mechanisms in Animals and Their Role in Speciation 29. Adaptive Evolution and Epigenetics
SECTION VI: Epigenetic Epidemiology30. Epigenetics of Livestock Breeding31. Nutritional Epigenetics and Metabolic Syndrome32. Epigenetics of Drug Addiction33. Environmental Influence of Epigenetics34. The Gut Microbiota Influence on Human Epigenetics, Health and Disease35. Population Pharmacoepigenomics
SECTION VII: Epigenetics and Human Disease36. Cancer Epigenetics37. The Role of Epigenetics in Autoimmune Disorders38. Epigenetics of Brain Disorders39. The Epigenetics of Metabolic Diseases40. Imprinting Disorders in Humans
SECTION VIII: Epigenetic Therapy41. DNA Demethylating Agents in Clinical Medicine42. Clinical Applications of Histone Deacetylase Inhibitors43. Combination Epigenetic Therapy
SECTION XI: The Future of Epigenetics44. New Directions for Epigenetic Research: Application of Engineered DNA-binding Molecules to Locus-specific Epigenetic Research
