MicroRNA in Human Malignancies offers a deep overview of the role and translational significance of miRNAs in the development of cancer and other malignancies. The book establishes the foundations of the field by covering essential mechanisms and the translational potential of miRNAs in the field of oncology. Specific topics covered include invasion and metastasis, miRNAs and metabolism, and opportunities of miRNAs in therapeutics. Chapters on diseases include content on disease-related pathophysiology, as well as diagnostic, prognostic and predictive value. This book is an essential reference for students entering the field, as well as researchers and investigators.
- Provides fundamental and translational chapters that facilitate the acquisition of knowledge needed to design and perform innovative miRNA-related research studies
- Synthesizes current research, with a critical review on the field
- Offers in-depth research by leading experts in the field
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
Illustrationen
Approx. 155 illustrations (30 in full color)
Dateigröße
ISBN-13
978-0-12-823274-3 (9780128232743)
Schweitzer Klassifikation
SECTION 1: miRNAs involvement in basic mechanisms of cancer development1. Overview on miRNA classification, biogenesis, and functions2. microRNA in cancer: overview3. miR-15/16 in human malignancies4. microRNAs and TP53 regulation5. microRNAs involvement in Invasion and metastasis6. microRNAs and metabolism7. microRNAs in inflammation processes
SECTION 2: miRNAs methodologies8. Wet-lab methods for miRNA analysis9. Bioinformatics utilities, web resources and integrative strategies for the analysis of miRNA regulatory networks10. Computational Resources for Analysis of miRNA Targetome11. miRNA bioinformatics and pathway analysis
SECTION 3: miRNAs involvement in therapeutics / theranostics12. Opportunities of miRNAs in cancer therapeutics
SECTION 4: miRNAs involvement in human cancer: pathophysiology and translational opportunities13. Pathophysiology roles and translational opportunities of miRNAs in acute leukemias14. Pathophysiology roles and translational opportunities of miRNAs in CLL15. Pathophysiology roles and translational opportunities of miRNAs in Lymphoma16. Pathophysiology roles and translational opportunities of miRNAs in Breast cancer17. Pathophysiology roles and translational opportunities of miRNAs in colorectal cancer18. Pathophysiology roles and translational opportunities of miRNAs in Lung cancer19. Pathophysiology roles and translational opportunities of miRNAs in Mesothelioma20. Pathophysiology roles and translational opportunities of miRNAs in Renal cancer21. Pathophysiology roles and translational opportunities of miRNAs in Pancreatic cancer22. Pathophysiology roles and translational opportunities of miRNAs in Prostate cancer23. Pathophysiology roles and translational opportunities of miRNAs in Hepatocarcinoma24. Pathophysiology roles and translational opportunities of miRNAs in Ovarian cancer25. Pathophysiology roles and translational opportunities of miRNAs in Bladder cancer26. Pathophysiology roles and translational opportunities of miRNAs in Cutaneous Melanoma27. Pathophysiology roles and translational opportunities of miRNAs in Brain tumors28. Pathophysiology roles and translational opportunities of miRNAs in Sarcomas
