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About the Editors, vii
List of Contributors, viii
Preface, xii
Acknowledgments, xiii
Part 1 The Aging Brain in Neurology, 1
1 The Biology of Aging: Implications for Diseases of Aging and Health Care in the Twenty-First Century, 3Douglas F. Watt
2 Functional Changes Associated with the Aging Nervous System, 38Julie A. Schneider and Chunhui Yang
Part 2 Assessment of the Geriatric Neurology Patient, 69
3 Approach to the Geriatric Neurology Patient: The Neurologic Examination, 71Marwan N. Sabbagh and Anil K. Nair
4 Assessment of Cognitive Status in Geriatric Neurology, 85
4.1 Mental Status Examination in the Geriatric Neurology Patient, 87Papan Thaipisuttikul and James E. Galvin
4.2 Neuropsychology in Geriatric Neurology, 98Donald J. Connor and Marc A. Norman
5 Cognitive Reserve and the Aging Brain, 118Adrienne M. Tucker and Yaakov Stern
6 Gait Disorders in the Graying Population, 126Joe Verghese and Jessica Zwerling
7 Imaging of the Geriatric Brain, 136
7.1 Structural Neuroimaging in Degenerative Dementias, 138Liana G. Apostolova
7.2 Functional Imaging in Dementia, 146Adam S. Fleisher and Alexander Drzezga
7.3 Amyloid Imaging, 162Anil K. Nair and Marwan N. Sabbagh
8 Clinical Laboratory Investigations in Geriatric Neurology, 170Geoffrey S. Baird and Thomas J. Montine
Part 3 Neurologic Conditions in the Elderly, 181
9 Cognitive Impairment and the Dementias, 183
9.1 Mild Cognitive Impairment, 187Ranjan Duara, Miriam Jocelyn Rodriguez, and David A. Loewenstein
9.2 Alzheimer's Disease, 200Martin R. Farlow
9.3 Dementia with Lewy Bodies, 208Clive Ballard
9.4 Vascular Cognitive Impairment, 224Helena C. Chui and Freddi Segal-Gidan
9.5 Frontotemporal Dementia, 239David Perry and Howard Rosen
9.6 Primary Progressive Aphasia, 251Maya L. Henry, Stephen M. Wilson, and Steven Z. Rapcsak
9.7 Prion Diseases, 267Michael D. Geschwind and Katherine Wong
9.8 Normal Pressure Hydrocephalus, 281Norman R. Relkin
10 Depression in the Elderly: Interactions with Aging, Stress, Chronic Pain, Infl ammation, and Neurodegenerative Disorders, 287Douglas F. Watt
11 Cerebrovascular Diseases in Geriatrics, 302Patrick Lyden, Khalil Amir and Ilana Tidus
12 Movement Disorders, 313
12.1 Parkinson's Disease, 315Robert Fekete and Joseph Jankovic
12.2 Essential Tremor and Other Tremor Disorders, 325Holly Shill
12.3 Progressive Supranuclear Palsy, 333Virgilio Gerald H. Evidente
12.4 Corticobasal Degeneration, 344Katrina Gwinn
13 Sleep Disorders, 347Sanford Auerbach
14 Autonomic Dysfunction and Syncope, 358Rohit R. Das
15 Geriatric Epilepsy, 370David V. Lardizabal
16 Vertigo and Dizziness in the Elderly, 379Terry D. Fife and Salih Demirhan
17 Disorders of the Special Senses in the Elderly, 396Douglas J. Lanska
18 Nervous System Infections, 460Ronald Ellis, David Croteau, and Suzi Hong
19 Delirium, 478Alan Lerner, Stefani Parrisbalogun, and Joseph Locala
20 Headache in the Elderly, 486Brian McGeeney
21 Neuromuscular Disorders, 494Heber Varela and Clifton Gooch
Part 4 Therapeutics for the Geriatric Neurology Patient, 519
22 Neurosurgical Care of the Geriatric Patient, 521David Fusco, Rasha Germain, and Peter Nakaji
23 Treatment of Dementia, 556
23.1 Evidence-Based Pharmacologic Treatment of Dementia, 557Jasmeet Singh, Marwan N. Sabbagh, and Anil K. Nair
23.2 Immunotherapy for Alzheimer's Disease, 574Michael Grundman, Gene G. Kinney, Eric Yuen, and Ronald Black
24 Geriatric Psychopharmacology, 586Sandra A. Jacobson
25 Nonpharmacologic Treatment of Behavioral Problems in Persons with Dementia, 615Gary A. Martin and John Ranseen
26 Expressive Art Therapies in Geriatric Neurology, 630Daniel C. Potts, Bruce L. Miller, Carol A. Prickett,Andrea M. Cevasco, and Angel C. Duncan
Part 5 Important Management Issues Beyond Therapeutics in the Geriatric Neurology Patient, 645
27 Dietary Factors in Geriatric Neurology, 647Yian Gu and Nikolaos Scarmeas
28 Exercising the Brain: Nonpharmacologic Interventions for Cognitive Decline Associated with Aging and Dementia, 669Brenna A. Cholerton, Jeannine Skinner, and Laura D. Baker
29 Driving Impairment in Older Adults, 682Anne D. Halli-Tierney and Brian R. Ott
30 Elder Abuse and Mistreatment, 699Elliott Schulman, Ashley Roque, and Anna Hohler
31 Advocacy in Geriatric Neurology, 707Glenn Finney and Anil K. Nair
Index, 713
Khalil Amir MD
Department of Neurology Cedars-Sinai Medical Centre Los Angeles, CA, USA
Liana G. Apostolova MD, MS
Department of Neurology David Geffen School of Medicine University of California Los Angeles, CA, USA
Sanford Auerbach MD
Departments of Neurology Psychiatry and Behavioral Neurosciences Boston University School of Medicine Boston, MA, USA
Geoffrey S. Baird MD
Departments of Laboratory Medicine and Pathology University of Washington Seattle, WA, USA
Laura D. Baker PhD
Department of Medicine - Geriatrics Wake Forest School of Medicine Winston-Salem, NC, USA
Clive Ballard MBChB MMedSci MRCPsych MD
Wolfson Centre for Age-Related Diseases King’s College London London, UK
Ronald Black MD
Chief Medical Officer Probiodrug AG Halle, Germany
Andrea M. Cevasco PhD, MT-BC
School of Music College of Arts and Sciences University of Alabama Tuscaloosa, AL, USA
Brenna A. Cholerton PhD
Department of Psychiatry and Behavioral Science University of Washington School of Medicine and Geriatric Research, Education, and Clinical Center Veterans Affairs Puget Sound Health Care System Seattle, WA, USA
Helena C. Chui MD
Department of Neurology Keck School of Medicine University of Southern California Los Angeles, CA, USA
Donald J. Connor PhD, PhD
Independent Practice Consultant in Clinical Trials San Diego, CA, USA
David Croteau MD
Department of Neurosciences and HIV Neurobehavioral Research Center University of California San Diego, CA, USA
Rohit R. Das MD, MPH
Indiana University School of Medicine Indianapolis, IN, USA
Salih Demirhan MD
Marmara University School of Medicine Istanbul, Turkey
Alexander Drzezga MD
Department of Nuclear Medicine University Hospital of Cologne Cologne, Germany
Ranjan Duara MD, FAAN
Wien Center for Alzheimer’s Disease and Memory Disorders Mount Sinai Medical Center Miami Beach; Department of Neurology Herbert Wertheim College of Medicine Florida International University, Miami and University of Florida College of Medicine University of Florida Gainesville, FL, USA
Angel C. Duncan MA-MFT, ATR
Cognitive Dynamics Foundation Neuropsychiatric Research Center of Southwest Florida Albertus Magnus College American Art Therapy Association Fort Myers, FL, USA
Ronald Ellis MD, PhD
Virgilio Gerald H. Evidente MD
Movement Disorders Center of Arizona Ironwood Square Drive Scottsdale, AZ, USA
Martin R. Farlow MD
Department of Neurology Indiana University Indianapolis, IN, USA
Robert Fekete MD
Department of Neurology New York Medical College Valhalla, NY, USA
Terry D. Fife MD, FAAN
Barrow Neurological Institute and Department of Neurology University of Arizona College of Medicine Phoenix, AZ, USA
Glenn Finney MD
Department of Neurology McKnight Brain Institute Gainesville, FL, USA
Adam S. Fleisher MD, MAS
Banner Alzheimer’s Institute Department of Neurosciences University of California San Diego, CA, USA
David Fusco MD
Division of Neurological Surgery Barrow Neurological Institute St. Joseph’s Hospital and Medical Center Phoenix, AZ, USA
James E. Galvin MD, MPH
Department of Neurology and Department of Psychiatry New York University Langone Medical Center New York, NY, USA
Rasha Germain MD
Michael D. Geschwind MD, PhD
Memory and Aging Center Department of Neurology University of California San Francisco, CA, USA
Clifton Gooch MD, FAAN
Department of Neurology University of South Florida College of Medicine Tampa, FL, USA
Michael Grundman MD, MPH
President, Global R&D Partners, LLC San Diego, CA, USA
Yian Gu PhD
Taub Institute for Research on Alzheimer’s Disease and the Aging Brain Columbia University Medical Center New York, NY, USA
Katrina Gwinn MD
National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda, MD, USA
Anne D. Halli-Tierney MD
Warren Alpert Medical School of Brown University Rhode Island Hospital Providence, RI, USA
Maya L. Henry PhD
Department of Communication Sciences and Disorders University of Texas at Austin and Memory and Aging Center Department of Neurology University of California San Francisco, CA, USA
Anna Hohler MD
Department of Neurology Boston University School of Medicine Boston, MA, USA
Suzi Hong PhD
Department of Psychiatry School of Medicine University of California San Diego, CA, USA
Sandra A. Jacobson MD
University of Arizona College of Medicine-Phoenix Banner Sun Health Research Institute and Cleo Roberts Center for Clinical Research Sun City, AZ, USA
Joseph Jankovic MD
Parkinson’s Disease Center and Movement Disorders Clinic Department of Neurology Baylor College of Medicine Houston, TX, USA
Gene G. Kinney PhD
Chief Scientific Officer Prothena Biosciences, Inc. South San Francisco, CA, USA
Douglas J. Lanska MD, MS, MSPH, FAAN
Neurology Service Veterans Affairs Medical Center Great Lakes Health Care System Tomah, WI, USA
David V. Lardizabal MD
Epilepsy Program and Intraoperative Monitoring University of Missouri Columbia, MO, USA
Alan Lerner MD
Department of Neurology Case Western Reserve University School of Medicine Cleveland, OH, USA
Joseph Locala MD
Department of Psychiatry Case Western Reserve University School of Medicine Cleveland, OH, USA
David A. Loewenstein PhD, ABPP
Department of Psychiatry and Behavioral Sciences Miller School of Medicine University of Miami Miami, FL, USA
Patrick Lyden MD
Department of Neurology Cedars-Sinai Medical Center Los Angeles, CA, USA
Gary A. Martin PhD
Integrated Geriatric Behavioral Health Associates Scottsdale, AZ, USA
Brian McGeeney MD
Bruce L. Miller MD
Memory and Aging Center University of California San Francisco, CA, USA
Thomas J. Montine MD
Departments of Pathology and Neurological Surgery University of Washington Seattle, WA, USA
Anil K. Nair MD
Clinic for Cognitive Disorders and Alzheimer’s Disease Center Quincy Medical Center Quincy, MA, USA
Peter Nakaji MD
Marc A. Norman PhD, ABPP
Department of Psychiatry University of California San Diego, CA, USA
Brian R. Ott MD
Warren Alpert Medical School of Brown University and The Alzheimer’s Disease and Memory Disorders Center Rhode Island Hospital Providence, RI, USA
Stefani Parrisbalogun MD
Rawson-Neal Psychiatric Hospital Las Vegas, NV, USA
David Perry MD
Memory and Aging Center Department of Neurology School of Medicine University of California San Francisco, USA
Daniel C. Potts MD
Cognitive Dynamics Foundation Veterans Affairs Medical Center The University of Alabama Tuscaloosa, AL, USA
Carol A. Prickett PhD, MT-BC
John Ranseen PhD
Department of Psychiatry University of Kentucky College of Medicine Lexington, KY, USA
Steven Z. Rapcsak MD
Department of...
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