ACL Injury Epidemiology.- History of ACL Treatment and Current Gold Standard of Care.- ACL Clinical Outcomes.- ACL Treatment in the Skeletally Immature Patient.- The Biology of the Normal ACL.- The Role of Inflammation and Blood Cells in Wound Healing.- The ACL Response to Injury.- The Biology of Impaired Healing of Joint Issues.- Translational Medicine.- In Vitro Models of ACL Injury.- In Vivo Models of ACL Injury (Central Defect, Porcine, Ovine, Canine).- Tissue Engineering of Ligaments and Tendons.- Outcome Assessment for ACL Tissue Engineering.- Scaffolds and Biologic Additives for ACL Surgery.- Use of Biologics to Treat Partial ACL Tears.- Can We Get a Complete ACL Tear to Heal?.- The Effects of Platelets and Their Concentration on ACL Healing.- The Effects of WBCs and RBCs on Ligament Healing.- Safety of the Bioenhanced Repair.- Re-Innervation and Revascularization in Engineered ACL Healing.- Bio-enhancement of ACL Graft Healing.- The Effects of Age and Skeletal Maturity on Healing of the Anterior Cruciate Ligament.