Advances in Diagnostics and Immunotherapeutics for Neurodegenerative Diseases

Name: Advances in Diagnostics and Immunotherapeutics for Neurodegenerative Diseases
Brand: De Gruyter
Price: 54.1 EUR
Availability: OnlineOnly

Anuradha Mishra Preeti Bajpai Tarique Mahmood Ansari(Autor*in)

De Gruyter (Verlag)

1. Auflage

Erschienen am 13. August 2024

231 Seiten

E-Book

ePUB mit Adobe-DRM

Systemvoraussetzungen

978-981-5238-75-4 (ISBN)

54,10 €inkl. 7% MwSt.

Systemvoraussetzungen

für ePUB mit Adobe-DRM

E-Book Einzellizenz

Als Download verfügbar

Beschreibung

Weitere Details

Weitere Ausgaben

Inhalt

Cover
Title
Copyright
End User License Agreement
CONTENTS
FOREWORD
PREFACE
INTRODUCTION
List of Contributors
A Systematic Review of Neurodegenerative Diseases: Etiology, Clinical Symptoms, Pathogenesis, and Future Developments
Satya Prakash Singh1,*, Deepti Dwivedi2, Rabiya Ahsan3, Ankur Srivastava4 and Ajay Kumar Shukla4
INTRODUCTION
Parkinson's Disease
Huntington's Disease
Alzheimer's Disorders
Amyotrophic Lateral Sclerosis (ALS)
Symptoms of Neurodegenerative Diseases
Neurodegeneration: Etiologies
Ageing: Relevant to the Growth of Neurodegenerative Disorders
Neurodegenerative Disorders Caused by Mitochondrial Dysfunction
Recent Treatments of Cognitive Impairments
Pathologies that Mitochondrial DNA Mutations may Cause
CONCLUSION AND FUTURE DEVELOPMENTS
ABBREVIATIONS
REFERENCES
Neuro-inflammatory Responses in Alzheimer's v/s Parkinson's Diseases
Amrutha K.1 and Sarika Singh1,2,*
INTRODUCTION
INFLAMMATORY RESPONSES IN ALZHEIMER'S DISEASE
INFLAMMATORY RESPONSES IN PARKINSON'S DISEASE
APPLICATION OF NEUROINFLAMMATORY RESPONSES FOR DISEASE DIAGNOSIS
TUMOR NECROSIS FACTOR-? (TNF-?)
INTERLEUKIN-1? (IL-1?)
NITRIC OXIDE (NO)
CYCLOOXYGENASE- 2 (COX-2)
INTERFERONS (IFNS)
ASTROCYTES
UTILIZATION OF NEUROINFLAMMATORY RESPONSES FOR THERAPEUTICS
CONCLUSION
REFERENCES
Immunopathogenesis of Alzheimer's disease, Parkinson's Disease, and other Neurodegenerative Diseases
Sunil Kumar1, Ajay Kumar Shukla2, Vimal Kumar Yadav2, Ankur Srivastava2, Deepti Dwivedi3 and Satya Prakash Singh1,4,*
INTRODUCTION
Worldwide Data of AD
Pathophysiology of Immunopathogenic Neurodegenerative Disease Hypotheses
AMYLOID-? HYPOTHESIS
Protein Aggregation
CHOLINERGIC HYPOTHESIS
METAL HYPOTHESIS
TAU PROTEIN HYPOTHESIS
Toxic Oligomer' Hypothesis
Protein Homeostasis Hypothesis (Protein (Mis) Folding)
Dissents and Molecular Chaperones
Protein Misfolding and Endoplasmic Reticulum Stress
Unfolded Protein Response (UPR)
Interaction of Proteins
Autophagy and Neurodegeneration
UPS in Neurodegenerative Disorders
Aggresomes
OXIDATIVE STRESS
Metals and Oxidative Stress
Oxidative Stress in Other Neurodegenerative Disorders
IMPAIRED MITOCHONDRIAL DYSFUNCTION HYPOTHESIS
FRAGMENTATION OF NEURONAL GOLGI HYPOTHESIS
DISRUPTION OF CELLULAR/AXONAL TRANSPORT DYSREGU- LATION HYPOTHESIS
Axonal Transport in Other Neurodegenerative Diseases
DYSFUNCTION OF NEUROTROPHINS HYPOTHESIS
NEUROINFLAMMATORY HYPOTHESIS
THE ROLE OF CHEMOKINES IN NEURODEGENERATIVE DISEASES (NDD) HYPOTHESIS
CCL2 (Monocyte Chemoattractant Protein
Human Macrophage Inflammatory Protein 1a (CCL3)
CXCL8 (Interleukin 8)
CXCL12 (Stromal Cell-Derived Factor 1)
CX3CL1 (Fractalkine)
MULTIFACETED NEURONAL DEATH HYPOTHESIS
Cell Death Cascades in NDDs
THE IMMUNOPATHOGENESIS OF GUT MICROBIOTA HYPOTHESIS
Gut Microbiota Responsible for Neurodegenerative Diseases
Gut Microbiota Impact on Immune System and Neuroinflammation
Gut Microbiota Impact on Activities
NEUROTRANSMITTERS HYPOTHESIS
NEW INSIGHTS PATHOGENESIS
Gamma Oscillations Ameliorate Pathology and Cognitive Impairment in AD
Aß and Tau Prions Spread Through the Brains of AD Patients
Aß Interact with Hippocampal Ghrelin/GHSR1a Signaling in AD
Aß Constrict Cerebral Capillaries in AD Pathology
CONCLUSION
AUTHOR CONTRIBUTIONS
REFERENCES:
Immunobiology and Immunotherapies in Huntington's Disease
Arttatrana Pal1,*, Golden Kumari1 and Sonu Kumar1
INTRODUCTION
IMMUNE SYSTEM AND BRAIN
Immune System and HD brain
Mechanisms of Neurodegeneration in HD
Clinical Features in HD
Immune Complement System in HD
Pathways of the Complement System and Cytokines in HD
Neuro-inflammation and Neurodegeneration in HD
ROLE OF INNATE AND ADAPTIVE IMMUNE RESPONSES IN HD
Role of Microglia
mHTT and Inflammation
Monocytes and Macrophages in HD
Complement System
IL-6
IL-1ß
TNF-a
TLRs
Mast Cells
ROLE OF ADAPTIVE IMMUNE RESPONSES IN HD
Dendritic Cells
T Cells
IL-4
Immune Treatment for HD
IMMUNOMODULATORY DRUGS FOR HD
Drugs for Chorea in HD
Tetrabenazine
Deutetrabenazine
Dopamine Antagonists
Anti-glutamatergic
Antipsychotic Medication
More Drugs for HD
Laquinimod
Anti-semaphorin 4D
Anti-TNF-a Therapy
Immunotherapies for mHTT
Antibody-based Therapy for HD
Indirect Therapies Helpful for HD Subjects Along with Immunotherapy
Speech Therapy
Physical Therapy and Establishing a Routine Activity
Supplements for HD
Future Perspectives
CONCLUSION
REFERENCES
Introduction to Gut Microbiota and their Effects on Various Brain Disorders
Afreen Usmani1,* and Anuradha Mishra2
INTRODUCTION
EFFECTS OF INTESTINAL MICROBIOME-BASED THERAPIES ON NEURODEGENERATIVE DISEASES
Alzheimer's Disease (AD)
Parkinson's Disease (PD)
Amyotrophic Lateral Sclerosis (ALS)
Huntington's Disease (HD)
Neurodegenerative Diseases and Short Chain Fatty acids (SCFAs)
CONCLUSION
Future Perspective
ACKNOWLEDGEMENT
REFERENCES
Interplay Between Gut-microbiota and Neurodegeneration
Sumel Ashique1,*, Radheshyam Pal1, Shubneesh Kumar2, Bharti Verma3, Nitish Kumar3, Ivan Kahwa4, Arshad Farid5, Neeraj Mishra6,*, Prashant Kumar7 and Farzad Taghizadeh-Hesary8,9
INTRODUCTION
GUT MICROBIOTA
Gut Microbiota and Neurodegenerative Disease: A Correlation
BRAIN AND GUT MICROBIOTA COMMUNICATIONS
Gut-Brain Axis
Blood-Brain Barrier and Molecules Derived from the Gut
Central Nervous System Modifications
Modification of Immune System
A NEW PARTICIPANT IN NEURODEGENERATIVE DISEASES: GUT MICROBIOTA: CNS HOMEOSTASIS
Microbiome's Role in Alzheimer's Disease (AD)
Microbiome's Role in Parkinson's Disease
Microbiome's Role in Huntington's Disease
Microbiota Implicates Internal Factor - Influence on Multiple Sclerosis
Gut Microbiota and Amyotrophic Lateral Sclerosis/Frontotemporal Dementia
Gut Microbiota and Various Different Forms of Dementia
GUT MICROBIOME, OXIDATIVE STRESS, AND NEURODE- GENERATION
GUT MICROBIOME IN NEUROPROTECTION
Gut Microbiome Metabolites for Neuroprotection with their Cell-specific Responses
Gut Microbiome Interaction with Specific Host Molecules
Interaction between Dietary Molecules and Gut Microbiome
ASSESSING THE IMPACT OF GUT MICROBIOTA ON BRAIN NEURODEGENERATION USING EXPERIMENTAL MODELS
Systems for Continual Gut Microbiota Culture
Simulator of the Human Intestinal Microbial Ecosystem (SHIME)
TNO Gastro-Intestinal Model (TIM)
Dynamic Gastro-Intestinal Simulator (SIMGI)
CONCLUSION
ACKNOWLEDGMENT
REFERENCES
Epigenetic Regulation of Microglia: Plausible Mechanism and Interventional Approaches in Neurodegeneration
Sameen Shafi1, Hafizur Rahman Khan2 and Preeti Bajpai1,*
INTRODUCTION
Origin of Microglia
Microglial Polarization Phenotype
MICROGLIAL FUNCTIONS
Maintenance of Synapses
Synaptic Pruning
Regulating Nerve Network
Neurotransmitter Receptors on Microglia
EPIGENETIC REGULATION OF MICROGLIA
Histone Acetylation
Histone Methylation
DNA Methylation
Epigenetic Crosstalk
CONCLUSION
REFERENCES
Epigenetics as Diagnostic and Therapeutic Tool in Neurodegenerative Disorders
Rufaida Wasim1,*, Tarique Mahmood1, Farogh Ahsan1, Aditya Singh1 and Asad Ahmad1
INTRODUCTION
EARLY DIAGNOSIS AND TREATMENT
NEURODEGENERATIVE DISORDERS AND EPIGENETIC ALTE- RATION
POTENTIAL EPIGENETIC THERAPEUTIC INTERVENTION TARGETS
Inhibitors of DNA Methylation and DNA Methyltransferases (DNMT)
Histone Acetylation and Histone Deacetylases (HDAC) Inhibitors
NEURODEGENERATIVE DISORDERS TREATMENT
Alzheimer's Disease
Parkinson's Disease
Huntington's Disease
CONCLUSION
ACKNOWLEDGMENT
REFERENCES
Current Therapeutic Options and Repurposed Drugs for Neurodegeneration
Suneela Dhaneshwar1,*, Mohammad Aadil Bhat2, Anuradha Singh2 and Supriya Roy2
INTRODUCTION
Drug Repurposing
ALZHEIMER'S DISEASE (AD)
DRUG REPURPOSING FOR AD
Anti-cancer Agents
Epidermal Growth Factor Receptor Inhibitors (EGFRI)
Tyrosine Kinase Inhibitors
Retinoid X Receptor (RXR) Agonists
Miscellaneous Drugs
Antidiabetic Drugs
Hypoglycaemic Agents
Anti-hyperglycaemic Drugs
Antihypertensive Drugs
Antiepileptic Drugs
Phosphodiesterase-5 Inhibitors
PARKINSON'S DISEASE (PD)
Drug Repurposing for PD
Exenatide
Nilotinib
Terazosin
Simvastatin
Ursodeoxycholic Acid
ISRADIPINE
HUNTINGTON'S DISEASE (HD)
Drug Repurposing for HD
Tetrabenazine
Olanzapine
Memantine
Risperidone
Quetiapine
Amantadine
Statins
FRIEDREICH ATAXIA (FRDA)
Drug Repurposing
Dyclonine
Diazoxide
Dimethyl Fumarate
Etravirine
PPAR-? Agonist
SPINAL MUSCULAR ATROPHY (SMA)
Drug Repurposing for SMA
Riluzole and Rasalgiline
Masitinib
Amifampridine
Celecoxib and Hydroxyurea
Salbutamol
AMYOTROPHIC LATERAL SCLEROSIS (ALS)
Drug Repurposing for ALS
Ezogabine
Memantine
Masitinib
Rasagiline
Mexiletine
Ibudilast
Triumeq
CONCLUSION
REFERENCES
Subject Index
Back Cover

Systemvoraussetzungen

Als PDF speichern Als Link merken