It has been estimated that more than 8090 of the world's scientists who have ever lived are still alive today. It would not be unreasonable to suggest that more than 95% of those who have ever used a mass spectrometer are not only alive but are still actively employed. Most have never had any formal training in the subject since, with a few notable exceptions, universities have only recently begun to offer courses in mass spectrometry. We have written this book for the student of modern mass spectro metry: it is for the novice who wished to know what the instruments can do and how the techniques can be applied. There are other books on the market which delve into the history of mass spectrometry and go deeply into the mathematical theory and instrumentation. There are yet more books which guide one through the art of interpreting spectra. We have deliberately avoided these topics so that the reader is confronted only with the basic principles and is allowed a taste of the applications. One of the best methods of deVeloping a useful textbook is to teach a course based upon its content. This is what we did. We met in Houston in 1976 to teach a course on "Perspectives in Mass Spectrometry" and to coordinate our writing. The authors of five of the chapters met again in St.
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ISBN-13
978-1-4613-2982-4 (9781461329824)
DOI
10.1007/978-1-4613-2982-4
Schweitzer Klassifikation
1. Principles of Mass Spectrometry.- 1. History.- 2. The Electron Impact Mass Spectrum.- 3. Alternative Methods of Ionization.- 4. Exercises.- 5. Suggested Reading.- 2. Instrumentation for Mass Spectrometry.- 1. Introduction.- 2. The LKB 9000 Instrument.- 3. The Hewlett-Packard 5992 Instrument.- 4. The Kratos-AEI MS50 Instruments.- 5. Exercises.- 6. Suggested Reading.- 3. Combined Gas Chromatography-Mass Spectrometry.- 1. Introduction.- 2. Gas Chromatography.- 3. Gas Chromatography-Mass Spectrometry.- 4. Selected Applications.- 5. Exercises.- 6. Suggested Reading.- 4. Selective Ion Monitoring.- 1. Introduction.- 2. Operational Variables in Selective Ion Monitoring.- 3. Instrument Operation for Selective Ion Monitoring.- 4. Procedures for the Development of SIM Analyses.- 5. Applications of SIM to Other Fields of Study.- 6. Summary.- 7. Exercises.- 8. Suggested Reading.- 5. Concentration Techniques for Volatile Samples.- 1. Introduction.- 2. Selective Adsorption.- 3. Exercises.- 4. Suggested Reading.- 6. Automatic Data Processing.- 1. Introduction.- 2. Instrument Control and Data Acquisition.- 3. The Minicomputer.- 4. Interrupts and Asynchronous Processing.- 5. Interfacing.- 6. Timing.- 7. Designing the Interface.- 8. Designing the Software.- 9. Exercises.- 7. Collections of Mass Spectral Data.- 1. Introduction.- 2. Open-Ended Data Collections.- 3. Published Data Collections.- 4. Donations of Spectra.- 5. Exercise.- 6. Suggested Reading.- 8. The Mass Spectrometry Data Centre.- 1. History and Organization.- 2. Activities of the Centre.- 3. Suggested Reading.- 9. The Mass Spectral Search System.- 1. Introduction.- 2. History and Organization.- 3. The Mass Spectral Search System.- 4. Suggested Reading.- 10. Environmental Applications of Mass Spectrometry.- 1. Introduction.-2. Drinking Water Analysis.- 3. Study of a Landfill Leachate.- 4. A Study of the Houston Ship Channel.- 5. Summary.- 6. Exercises.- 7. Suggested Reading.- 11. Applications of Mass Spectrometry in the Pharmaceutical Industry.- 1. Introduction.- 2. Drug Metabolism.- 3. Medicinal Chemistry.- 4. Pharmaceutical Preparations.- 5. Summary.- 6. Exercises.- 7. Suggested Reading.- 12. Applications of Mass Spectrometry in the Petrochemical Industry.- 1. Introduction.- 2. Methods.- 3. Applications of High- and Ultrahigh-Resolution Instruments.- 4. Established Procedures.- 5. Miscellaneous Applications.- 6. Future Research.- 7. Exercises.- 8. Suggested Reading.- 13. Cosmochemical and Geochemical Applications of Mass Spectrometry.- 1. Introduction.- 2. Meteorites.- 3. Abiotic Synthesis.- 4. Lunar Samples.- 5. Ancient Sediments.- 6. Viking Mission to Mars.- 7. Conclusion.- 8. Exercises.- 9. Suggested Reading.- Solutions to Exercises.
