Advanced Therapy for Hepatitis C

Contributors vii
Preface xi
Section I Foundations for Understanding Antiviral Therapies in HCV
1 HCV Replication 3
Michael R. Beard
2 Hepatitis C Virus Genotypes 12
Scott A. Read and Mark W. Douglas
3 Immune Responses to HCV: Implications for Therapy 17
David G. Bowen
4 Mechanisms of Action of Antiviral Drugs: The Interferons 25
Edmund Tse and Michael R. Beard
5 Pharmacology and Mechanisms of Action of Antiviral Drugs: Ribavirin Analogs 36
Fred Poordad and Grace M. Chee
6 Pharmacology and Mechanisms of Action of Antiviral Drugs: Polymerase Inhibitors 43
Lotte Coelmont Leen Delang Mathy Froeyen Piet Herdewijn and Johan Neyts
7 Pharmacology and Mechanisms of Action of Antiviral Drugs: Protease Inhibitors 53
Laurent Chatel-Chaix Martin Baril and Daniel Lamarre
8 Measuring Antiviral Responses 60
Jean-Michel Pawlotsky and Stephane Chevaliez
Section II Efficacy and Clinical Use of Antiviral Therapies
9 Genotype 1: Standard Treatment 67
Rebekah G. Gross and Ira M. Jacobson
10 Individually Tailored Treatment Strategies in Treatment-na¨ive Chronic Hepatitis C Genotype 1 Patients 74
Johannes Wiegand and Thomas Berg
11 Genotype 1 Relapsers and Non-responders 84
Salvatore Petta and Antonio Craxì
12 Standard Therapy for Genotypes 2/3 90
Kenneth Yan and Amany Zekry
13 Altered Dosage or Durations of Current Antiviral Therapy for HCV Genotypes 2 and 3 97
Alessandra Mangia Leonardo Mottola and Angelo Andriulli
14 Genotypes 2 and 3 Relapse and Non-response 104
Stella Mart´inez Jose Maria Sanchez-Tapias and Xavier Forns
15 Hepatitis C Genotype 4 Therapy: Progress and Challenges 113
Sanaa M. Kamal
16 Antivirals in Acute Hepatitis C 127
Heiner Wedemeyer
17 Antivirals in Cirrhosis and Portal Hypertension 132
Diarmuid S. Manning and Nezam H. Afdhal
18 Treatment of Recurrent Hepatitis C Following Liver Transplantation 140
Ed Gane
19 Antiviral Treatment in Chronic Hepatitis C Virus Infection with Extrahepatic Manifestations 150
Benjamin Terrier and Patrice Cacoub
20 Cytopenias: How they Limit Therapy and Potential Correction 160
Mitchell L. Shiffman
21 The Problem of Insulin Resistance and its Effect on Therapy 169
Venessa Pattullo and Jacob George
22 HIV and Hepatitis C Co-infection 177
Gail V. Matthews and Gregory J. Dore
23 HCV and Racial Differences 185
Andrew J. Muir
24 HCV and the Pediatric Population 190
Kathleen B. Schwarz
25 New Horizons: IL28 Direct-acting Antiviral Therapy for HCV 196
Alexander J. Thompson John G. McHutchison and Geoffrey W. McCaughan
Index 215