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The Mongolian gerbil brain lies in the anatomy of the blood vessels supplying blood to the brain. In all mammals, there is a special mechanism that compensates for the decreased blood flow to the brain in the case of development of stroke. This mechanism is missing in the gerbil and therefore makes the Mongolian gerbil a unique model for stroke. Dr. Mayevsky adopted the gerbil as a model for stroke and his laboratory uniquely studied the mitochondria in the gerbil brain under various pathophysiological conditions.
This book describes the history of the Mongolian gerbil in research, the brain energy metabolism and mitochondrial function and brain real-time monitoring systems used in gerbils, as well as the brain vasculature of the Mongolian gerbil. Further, the book includes chapters on brain multisite recording under brain perturbations, multiparametric responses to brain activation, and the effect of neuroprotectants on the gerbil brain.
This is an ideal book for research teams researching stroke and epilepsy.
Dr. Avraham Mayevsky is a Professor Emeritus in The Mina & Everard Goodman Faculty of Life Sciences and the Leslie and Susan Gonda Multidisciplinary Brain Research Center at Bar-Ilan University in Ramat-Gan, Israel.
Dr Avraham Mayevsky's field of research since he started his Post-Doc training with Prof. Britton Chance in 1972, was Body Energy metabolism, including mitochondrial function in vivo, of the brain mainly and other tissues In Vivo, exposed to various pathophysiological conditions. During the 50 years of activity he and his team were able to accomplish a large number of goals that have a very significant impact on the understanding of pathophysiological processes in the brain and other organs evaluated under In Vivo conditions. His vision was to develop experimental approaches and tools that will enable them to study various physiological processes in experimental animals and at the same time, will be ready for clinical applications. During the years Dr Mayevsky's laboratory published more than 60 papers dealing with the subject of Cortical Spreading Depression of Leao (CSD).
Chapter 1 Historical Background of the Mongolian Gerbil in Research.- Chapter 2 Brain Energy Metabolism and mitochondrial function.- Chapter 3 Brain Real Time Monitoring systems used in Gerbils.- Chapter 4 Brain vasculature in the Mongolian Gerbil's.- Chapter 5 Brain Multisite recording under brain perturbations.- Chapter 6 Multiparametric Responses to Brain Oxygen Supply.- Chapter 7 Multiparametric Responses to Brain Activation.- Chapter 8 Neuroprotactants effect on the Gerbil Brain.- Chapter 9 Discussion and Conclusions.
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