The purpose of the present volume is to give a comprehensive and up-to-date 2 survey of the nature and role of calcium ions (Ca +) in the regulation of cel 2 lular function. Since Ca + has gained in interest over the past years as a cel lular messenger in signal transduction, and since the discovery of its cellular receptor protein, calmodulin, has helped in understanding its mode of action in molecular terms, we felt that an interdisciplinary selection of topics from the calcium field could provide a good source of information for all those in terested in calcium-mediated physiology. The volume begins with an overview on the synarchic nature of the two 2 cellular messengers, cyclic AMP and Ca +. The next three chapters deal with 2 the various transport mechanisms for Ca +. The biochemistry and molecular biology of calmodulin, as well as the cellular localization of calmodulin and calmodulin-binding proteins, are reviewed. Calcium regulation of smooth muscle contraction introduces the pharmacology of calcium antagonists.
Sprache
Verlagsort
Verlagsgruppe
Illustrationen
Dateigröße
ISBN-13
978-3-642-70070-5 (9783642700705)
DOI
10.1007/978-3-642-70070-5
Schweitzer Klassifikation
Ca2+ and cAMP in the Regulation of Cell Function.- Calcium Extrusion Across the Plasma Membrane by the Calcium-Pump and the Ca2+-Na+ Exchange System.- Voltage-Dependent Gating of Single Calcium Channels in the Cardiac Cell Membrane and Its Modulation by Drugs.- Mitochondrial Calcium Fluxes and Their Role in the Regulation of Intracellular Calcium.- Calmodulin Structure and Function.- Calmodulin Gene Structure and Expression.- Cellular Localization of Calmodulin and Calmodulin-Acceptor Proteins.- Calmodulin Antagonism.- Calcium Regulation of Smooth Muscle Contraction.- Pharmacology of Calcium Antagonists.- Biochemistry of the Ca2+- and Calmodulin-Dependent Regulation of the Cytoskeleton.- Calcium-Regulated Protein Phosphorylation in Mammalian Brain.- Calcium and Calmodulin Control of Neurotransmitter Synthesis and Release.- The Role of Calcium in Prostaglandin and Thromboxane Biosynthesis.- Calcium Regulation of Insulin Release.- Calcium Regulation of Histamine Secretion from Mast Cells.- Role of Calcium in Alpha-Adrenergic Regulation of Liver Function.- Calcium and Platelet Function.- Protein Kinase C and Polyphosphoinositide Metabolites: Their Role in Cellular Signal Transduction.
