The sense of smell and the olfactory system have been a subject of intrinsic interest for millenia. Inquiry into the structure and function of the olfactory system is based on a long tradition that dates back at least to the ancient Greeks. The mechanistic basis for the sensitivity and selectivity of this chemosensory detection system has always posed a challenge and remained largely a mystery. Recently, there has been a renaissance of interest in it and especially in the application of contemporary techniques of biochemistry and cellular and molecular biology. In this volume, current research utilizing these ap proaches is discussed in depth by a group of scientists who are among the current leaders in the applications of these techniques to the olfactory system. These authors address a wide range of questions that bear directly on the olfactory system but have broader biological implications as well. The various chapters have been grouped into five broad subject areas that emphasize diverse but related questions. "Transduction and Ligand-Receptor Interactions" considers the biochemical bases of stimulus access, interaction, transduction, elimination, and information processing.
Sprache
Verlagsort
Verlagsgruppe
Illustrationen
74 s/w Abbildungen
XVIII, 398 p. 74 illus.
Dateigröße
ISBN-13
978-1-4613-0989-5 (9781461309895)
DOI
10.1007/978-1-4613-0989-5
Schweitzer Klassifikation
I. Transduction and Ligand-Receptor Interactions.- 1. Olfactory Receptor Mechanisms: Odorant-Binding Protein and Adenylate Cyclase.- 2. Molecular Components of Olfactory Reception and Transduction.- 3. The Effect of Cytochrome P-450-Dependent Metabolism and Other Enzyme Activities on Olfaction.- 4. Odorant and Autonomic Regulation of Secretion in the Olfactory Mucosa.- 5. Autoradiographic Localization of Drug and Neurotransmitter Receptors in the Olfactory Bulb.- II. Molecular Biophysics And Membrane Function.- 6. Membrane Probes in the Olfactory System: Biophysical Aspects of Initial Events.- 7. Membrane Properties of Isolated Olfactory Receptor Neurons.- 8. Voltage-Clamp Studies of the Isolated Olfactory Mucosa.- III. Biochemical-Molecular Biological Studies.- 9. Neurotransmitter Plasticity in the Juxtaglomerular Cells of the Olfactory Bulb.- 10. Axoplasmic Transport in Olfactory Receptor Neurons.- 11. Molecular Cloning of Olfactory-Specific Gene Products.- IV. Development And Differentiation.- 12. Monoclonal Antibody Mapping of the Rat Olfactory Tract.- 13. Primary Olfactory Neuron Subclasses.- 14. Cellular Interactions in the Development of the Vertebrate Olfactory System.- 15. Olfactory Tissue Interactions Studied by Intraocular Transplantation.- V. Biological Relevance Of Olfactory Function.- 16. Age-Related Alterations in Olfactory Structure and Function.
