ContributorsPrefaceVOLUME 1Part I Introduction to Normal Bone Physiology and PathophysiologyChapter 1 The Bone Organ System: Form and FunctionCassandra A. Lee and Thomas A. EinhornChapter 2 Osteoblast BiologyJane B. Lian and Gary S. SteinChapter 3 Osteoclast BiologyF. Patrick Ross and Steven L. TeitelbaumChapter 4 The Biochemistry of BoneJayashree A. Gokhale, Pamela Gehron Robey, and Adele L. BoskeyChapter 5 Developmental Biology of BoneAnthony M. Reginato, Wenfang Wang, and Bjorn R. OlsenChapter 6 Mouse Genetics as a Tool to Study Bone Development and PhysiologyMillan S. Patel and Gerard KarsentyChapter 7 Parathyroid Hormone and Parathyroid Hormone-Related ProteinRobert A. NissensonChapter 8 CalcitoninAna O. Hoff, Gilbert J. Cote, and Robert F. GagelChapter 9 Vitamin D: Biology, Action, and Clinical ImplicationDavid Feldman, Peter J. Malloy, and Coleman GrossChapter 10 Regulation of Bone Cell Function by EstrogensBarry S. Komm and Peter V. N. BodineChapter 11 Skeletal Biology of AndrogensKristine M. Wiren and Eric S. OrwollChapter 12 Coupling of Bone Resorption and Formation during Bone RemodelingThomas J. Martin and Gideon A. RodanChapter 13 Cytokines and Bone RemodelingGregory R. Mundy, Babatunde Oyajobi, Kathy Traianedes, Sarah Dallas, and Di ChenChapter 14 Bone Growth FactorsXuezhong Qin, Reinhard Gysin, Subburaman Mohan, and David J. BaylinkChapter 15 Skeletal Heterogeneity and the Purposes of Bone Remodeling: Implications for the Understanding of OsteoporosisA. M. ParfittChapter 16 Basic Biology of BisphosphonatesH. FleischPart II Structure and BiomechanicsChapter 17 Skeletal Development: Mechanical Consequences of Growth, Aging, and DiseaseMarjolein C. H. van der Meulen, Dennis R. Carter, and Gary S. BeaupréChapter 18 Inhibition of Osteopenia by Biophysical InterventionClinton T. Rubin and Kenneth J. McLeodChapter 19 Biomechanics of Age-Related FracturesMary L. BouxseinPart III Epidemiology and Risk FactorsChapter 20 Introduction to Epidemiologic MethodsJennifer L. Kelsey and MaryFran SowersChapter 21 Magnitude and Impact of Osteoporosis and FracturesL. Joseph Melton III and Cyrus CooperChapter 22 Race, Ethnicity, and OsteoporosisMarie Luz Villa, Lorene Nelson, and Dorothy NelsonChapter 23 Epidemiology of Osteoporosis Fractures: The European ExperienceChris de Laet and Jonathan ReeveChapter 24 Bone Mineral Acquisition in Utero, during Infancy, and throughout ChildhoodBonny Specker, Ran Namgung, and Reggie C. TsangChapter 25 Bone Acquisition in AdolescenceJean-Philippe Bonjour and Rene RizzoliChapter 26 Genetics and Genomics of OsteoporosisAndré G. Uitterlinden, Johannes P. T. M. van Leeuwen, and Huibert A. P. PolsChapter 27 Nutrition and Risk for OsteoporosisRobert P. HeaneyChapter 28 Physical Activity and OsteoporosisBelinda R. Beck, Janet Shaw, and Christine M. SnowChapter 29 Premenopausal Reproduction and Hormonal Characteristics and Risk for OsteoporosisMaryFran SowersChapter 30 Postmenopausal Endogenous and Exogenous Hormones, Degree of Obesity, Thiazide Diuretics, and Risk of OsteoporosisJane A. Cauley and Loran M. SalamoneChapter 31 The Effects of Tobacco and Alcohol Use on BoneEgo SeemanChapter 32 Falls as Risk Factors for FracturesAnne Schwartz, Elizabeth Capezuti, and Jeane Ann GrissoChapter 33 Assessing Fracture RiskCharles W. Slemenda, C. Conrad Johnston, and Siu L. HuiChapter 34 Outcomes of Osteoporotic FracturesElizabeth Barrett-Conner and Gail GreendaleVOLUME 2Part IV PathophysiologyChapter 35 The Nature of OsteoporosisRobert Marcus and Sharmilla MajumderChapter 36 Local and Systemic Factors in the Pathogenesis of OsteoporosisLawrence R. RaiszChapter 37 Animal Models for in Vivo Experimentation in Osteoporosis ResearchDonald B. KimmelChapter 38 The TypeI/Type II Model for Involutional Osteoporosis: Update and Modification Based on New ObservationsB. Lawrence Riggs, Sundeep Khosla, and L.