This book covers two areas, the first detailing the concepts and technologies of drug-device combination products. The second area includes case studies of important products that either significantly shape our technologies and thinking, or contribute to current healthcare practice.The book:
* Discusses where drugs and devices work, where they fail, and when they need to work with each other
* Reviews interactions between human bodies and the drug-device combination products the measurements of these interactions
* Covers how a drug-device combination product is developed, tested, and regulated
* Includes case studies of steroid releasing leads, AOA treated tissue heart valves, intrathecal drug delivery pumps, infuse bone grafts, drug eluting stents, and antimicrobial meshes
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Auflage
Sprache
Verlagsgruppe
Dateigröße
ISBN-13
978-1-119-00300-7 (9781119003007)
Schweitzer Klassifikation
FOREWORD vii
PREFACE ix
PART I BACKGROUNDS 1
1 Addressing Medical Device Challenges with Drug-Device Combinations 3
2 Historical Survey of Drug Delivery Devices 39
3 Development of Combination Product Drug Delivery Systems 66
4 Drug-Material Interactions, Materials Selection, and Manufacturing Methods 89
PART II PRODUCTS 117
5 Steroid-Releasing Lead 119
6 Thromboresistant Vascular Graft 142
7 Device-Enabled Drug Infusion Therapies 182
8 Promus Element Plus®: A Drug-Eluting Stent 214
9 Infuse® Bone Graft 241
INDEX 261
