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Take an evidence-based approach to prescribing decisions with this comprehensive guide
Prescribing decisions are among the most important parts of clinical practice. Balancing patient needs, possible drug interactions, the probability of adverse drug reactions, and more requires an evidence-based approach rooted in pharmacological principles. The New Prescriber: An Integrated Approach to Medical and Non-medical Prescribing offers a thorough, accessible introduction to the core components of prescribing, essential for any student preparing for clinical practice. Now fully updated to reflect the latest best practices and to address questions raised by different prescribing settings, it promises to continue as the key introduction to this vital subject.
Readers of the second edition of The New Prescriber will also find:
The New Prescriber is ideal for all non-medical prescribing students, nursing, allied health professionals, and medical students.
Joanne Lymn is Professor of Healthcare Education at University of Nottingham, UK, and a National Teaching Fellow.
Alison Mostyn is Professor of Pharmacology Education for Health and Director of Teaching and Learning, University of Nottingham, UK.
Roger Knaggs is Professor of Pain Management at University of Nottingham, UK, and Specialist Pharmacist in Pain Management at Primary Integrated Community Services. He is also President of the British Pain Society.
Michael Randall is Professor of Pharmacology at University of Nottingham, UK, and a Fellow of the British Pharmacological Society.
Dianne Bowskill is Associate Professor of Prescribing Education and Lead for Non-medical prescribing, University of Nottingham, UK.
List of Contributors xxvi
Foreword xxvii
Preface xxviii
Acknowledgements xxix
Section 1 The Patient 1
Section Introduction 1
1 The Consultation 3 Frank Coffey and Dianne Bowskill
2 Accountability and Prescribing 14 Matthew Boyd, Stephanie Bridges, and Helen Boardman
3 Prescribing and the Law 23 Richard Griffith
4 The Ethics of Prescribing 36 Matthew Boyd, Stephanie Bridges, and Helen Boardman
5 Prescribing in Practice 44 Dianne Bowskill and Daniel Shipley
6 Public Health Issues 53 Michael Watson and Katharine Whittingham
Section 2 Pharmacology 63
Section Introduction 65
7 General Principles of Pharmacology 67 Joanne Lymn and Alison Mostyn
8 Pharmacokinetics 1: Absorption and Distribution 79 Joanne Lymn and Alison Mostyn
9 Pharmacokinetics 2: Metabolism and Excretion 92 Joanne Lymn and Alison Mostyn
10 Routes of Administration 106 Joanne Lymn and Roger Knaggs
11 Variations in Drug Handling 114 Michael Randall
12 Polypharmacy and Medicines Optimisation 124 Daniel Shipley
13 Adverse Drug Reactions and Interactions 134 Alison Mostyn and Daniel Shipley
14 Introduction to the Autonomic Nervous System 144 Joanne Lymn
15 Clinical Application of the Principles of the Autonomic Nervous Systems 157 Joanne Lymn
16 The Gastrointestinal System 167 Michael Randall
17 Cardiovascular Drugs and Diseases 177 Richard Roberts
18 Haemostasis and Thrombosis 196 Michael Randall
19 The Renal System 208 Michael Randall
20 The Respiratory System 221 Richard Roberts
21 Introduction to the Central Nervous System 235 Yvonne Mbaki
22 Neurodegenerative Disorders 245 David Kendall
23 Depression and Anxiety 256 Yvonne Mbaki
24 Schizophrenia 267 David Kendall
25 Epilepsy and Antiseizure Drugs 277 Michael F O'Donoghue and Christina Giavasi
26 Pain and Analgesia 293 Roger Knaggs
27 Drugs of Misuse 308 Michael Randall
28 Antibacterial Chemotherapy 315 Tim Hills
29 Antibiotic Resistance and Clostridioides Difficile 331 Tim Hills
30 Antifungal and Antiviral Drugs 342 Tim Hills
31 The Endocrine System 352 Alison Mostyn and Daniel Shipley
32 Contraception and Reproductive Health 369 Alison Mostyn and Anna Soames
33 Cancer Pharmacotherapy 381 Michael Randall
34 Musculoskeletal Disease 392 Sana Awan and David Andrew Walsh
Glossary 409
Activity Answers 417
Index 445
Frank Coffey and Dianne Bowskill
By the end of this chapter the reader should be able to:
As you begin your prescribing education you already have a wealth of professional experience in your own area of practice. The assessment and consultation skills learnt as part of professional registration are well practised but may need to be refined as you take on prescribing. We are not suggesting that you need to adopt a new or medical model of consultation, although this might be desirable in certain advanced practice roles. For the majority of new prescribers, the focus will be on analysing their current framework of assessment or consultation and identifying adaptations required to support prescribing decisions. In this chapter we will ask you to think about the elements of the consultation that you may need to adapt or work on. We will give practice tips and point out common errors that can affect the quality of a consultation.
Prescribing inherently brings with it a greater requirement to make a diagnosis. This responsibility may be new and quite daunting. Prescribers need to understand the diagnostic process. In most circumstances, the key factor for accurate diagnosis is eliciting a good history. For this reason, we will look in detail at the elements of a history. Examination and investigations are directed by and supplement the history. The depth and focus of the history and examination will vary depending on the setting and your role. Wherever you work, however, it is essential to be thorough and systematic, and above all to know the bounds of your competence. History taking, examination and clinical decision making are skills that need to be continuously practiced under expert supervision.
Ideally your prescribing will be effective, but above all it should be safe. The primary dictum of all healthcare practice is 'primum non nocere' (above all do no harm). We will outline the elements of the consultation that are essential for safe prescribing, the 'bottom liners' of a prescribing consultation.
In the final part of the chapter, we will explore the potential impact of technological and scientific advances on assessment and clinical decision making and outline the increasing emphasis on health improvement and prevention in consultations.
The consultation is a two-way interaction between a healthcare practitioner and a patient. Your role will influence the types of patients you treat, the environment in which you see them and your approach to the consultation. As a non-medical prescriber your focus is on diagnosis. Assessment for diagnosis in a typical consultation comprises the history, examination and investigations. Factors to consider include the urgency and seriousness of the presentation, time constraints and the personalities, culture, language and medical knowledge of both the patient and the clinician. Previous contact with the patient, autonomy, and confidence are further influences on the consultation. Communication and consultation skills are inextricably interlinked. There are many excellent textbooks available for prescribers who wish to enhance their communication skills (Brown et al. 2016; Silverman et al. 1998; Berry 2004).
Although consultations differ in specifics, there are common elements and generic skills that are applicable in varying degrees to any given situation. Numerous consultation models have been developed over the years, for example Neighbour (2005), Pendleton et al. (2003) and Calgary Cambridge in Silverman et al. (1998). Rather than dwelling on the theory underpinning consultations, we will describe a practical framework for the consultation (see Box 1.1). This includes an assessment component (see I to (j) in Box 1.1) and other elements which can be applied in varying degrees to all consultations.
It is important for consultations to have a degree of structure. The skill in consulting is to maintain a structure and system that includes all the vital elements and yet does not feel like a straitjacket for the patient or clinician. In the following section we will analyse the different elements of the consultation in more detail and highlight those that are likely to change or need more emphasis for you as you take on prescribing.
Using Box 1.1 as a framework, reflect on your current consultations and identify elements you are less confident with. Make a note of these to inform learning and development needs.
Take time to study all the information available to you about the patient prior to the consultation. Study referral letters and available medical records for vital information, including the patient's past history, medications and allergies. Set goals for the consultation and ensure that the environment is set up appropriately with adequate lighting and privacy.
First impressions are especially important and will influence your subsequent relationship with the patient. If you have not encountered the patient before, introduce yourself by name and explain your role. Check the patient's details (name, date of birth, address). Observe the patient's demeanour and physical appearance. The patient will invariably be feeling nervous. Put them at ease by projecting confidence and warmth, and they are more likely to open up to you during the consultation.
Elements (c) to (g) in Box 1.1 are primarily concerned with the taking of a history and the consideration of differential diagnoses. The importance of the history cannot be overstated. In the vast majority of cases (>70%) the history will provide an accurate diagnosis or differential diagnosis even before the examination and investigations are performed. A good history will therefore facilitate effective prescribing. Certain minimum information must be elicited to ensure safe prescribing,
The history is a two-way process. In reality, we do not 'take' a history. Rather, we 'make' a history with the patient. The result is influenced by both the practitioner's and the patient's prior knowledge, experiences and understanding of language. Where understanding of language is a barrier, clinical risk is significantly increased and an interpreter should be considered. There are psychodynamic processes at play during any consultation which the practitioner needs to be aware of. These are explored in detail in other publications (Berry 2004).
The scope and depth of the history will depend on the role of the practitioner and the circumstances surrounding the consultation. Whatever the nature of the history, it is essential to be systematic and as far as possible follow the same sequence of questioning each time. In this way vital information will not be overlooked. This becomes particularly important when the patient has multiple symptoms and/or a complicated medical history.
Most patient histories will contain some or all the elements of a traditional medical history. This structure has limitations and has been criticised for being practitioner...
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