Systems Biology for Traditional Chinese Medicine

Foreword
Preface
Abbreviations
Chapter 1. Introduction of systems biology of Traditional Chinese Medical (TCM)
1.1 Characteristics and compatibility principles of Traditional Chinese medicine (TCM)
1.2 Key scientific issues in TCM modernization
1.3 Development of systems biology
1.4 Chemomics-integrated systems biology
1.5 Research strategy and prospective of systems biology in TCM
Chapter 2. Chemomics of Traditional Chinese Medicine
2.1 Characteristics and research difficulties of TCM
2.2 Background of TCM chemomics proposal and development
2.3 Chemomics
2.4 Chemomics and the research of composite formular
Chapter 3. Technological platform of TCM chemomics
3.1 Acquisition methods and techniques for TCM chemomics
3.2 Characterization techniques of Chemome-TCM fingerprinting
3.3 Information processing for the study of TCM chemomoics
3.4 Development of intelligent quality control system in the process of Chinese medicine production
Chapter 4. Pharmacokinetic investigation on TCM formula based on global systems biology
4.1 Pharmacokinetic characteristics of TCM formula
4.2 Methodology of pharmacokinetics of TCM formula
4.3 Application of PK-PD model in the toxicological research of Liushen pills
4.4 Project
Chapter 5. Application of genomics in the research of TCM
5.1 Genomics and TCM system research
5.1 Introduction
5.2 Prospect of genomics in TCM research
5.3 Cases of the application of genomics in TCM research
Chapter 6. Proteomics study on TCM
6.1 Proteomics in TCM research
6.2 A case study of proteomics in TCM
6.3 Application of high content screening in TCM research
6.4 Limitations and prospect of TCM research
Chapter 7. Application of metabonomics in research on TCM
7.1 Current research situation of Metabonomics
7.2 Integrating of Quantitative Metabonomics Platform Technology
7.3 Application of Metabonomics in the field of medicine
7.4 Examples of metabonomics research on TCM
Chapter 8. Application of chemometrics and bioinformatics in TCM research
8.1 Introduction of chemometrics
8.2 Chemometric techniques and their applications in TCM research
8.3 Introduction of bioinformatics
8.4 Bioinformatics techniques and their applications in the research of TCM
8.5 Conclusions
Chapter 9. Study of integrated biomarker system of Diabetic nephropathy
9.1 Introduction of Diabetic nephropathy
9.2 Mogensen staging and TCM typing of DN
9.3 Metabonomics study of DN
9.4 Condition of metabolism after treatment with TangShen formula (TSF)
9.5 2mRNA study based on TCM syndrome differentiation typing
9.6 Integrated biomarker system of DN
9.7 Conclusions
Chapter 10. Chemomics Research on Composite of Qingkailing (QKL) Injection
10.1 Chemomics research of QKL injection
10.2 Pharmacodynamic evaluation methods of QKL injection
10.3 Research on the simplified QKL formula
10.4 Conclusions
Chapter 11. Integrated global systems biology for the research and development of Chinese medicine Shuanglong Formula
11.1 Brief introduction of shuanglong formula
11.2 Chemomics study of shuanglong formula
11.3 Pharmacodynamic evaluation of SLF effective ingredients
11.4 Systems biology study of the mechanism of directed differentiation of stem cells induced by NSLF6
11.5 Anti-myocardial infarction effect of SLF
11.6 Conclusions
Chapter 12. Demonstrative Research on the Safety Evaluation of Liushenpills
12.1 Introduction
12.2 Toxicity study of Chanshu
12.3 Chemomic study on LSP
12.4 Assessment of effectiveness and safety of LSP
12.5 In vivo distribution and metabonomics of LSP and Xionghuang
12.6 Metabonomic research of LSP
12.7 Conclusions
Index