Functional and Molecular Imaging in Oncology, An Issue of Magnetic Resonance Imaging Clinics of North America

Name: Functional and Molecular Imaging in Oncology, An Issue of Magnetic Resonance Imaging Clinics of North America
Brand: Elsevier
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Antonio Luna(Autor*in)

Elsevier (Verlag)

1. Auflage

Erschienen am 19. Januar 2016

100 Seiten

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978-0-323-41699-3 (ISBN)

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Front Cover
Functional and Molecular Imaging in Oncology
Copyright
Contributors
CONSULTING EDITORS
EDITOR
AUTHORS
Contents
Foreword: Functional MR Imaging in Oncology
Preface: MR Imaging Pushes Radiologists to Move Forward in Oncologic Imaging
Functional MR Imaging Techniques in Oncology in the Era of Personalized Medicine
MR Imaging Biomarkers in Oncology Clinical Trials
Body Diffusion-weighted MR Imaging in Oncology: Imaging at 3 T
Assessment of Tumor Angiogenesis: Dynamic Contrast-enhanced MR Imaging and Beyond
Clinical Imaging of Tumor Metabolism with 1H Magnetic Resonance Spectroscopy
Multiparametric MR Imaging in the Assessment of Brain Tumors
Evaluation of Head and Neck Tumors with Functional MR Imaging
Functional MR Imaging in Chest Malignancies
Multiparametric MR Imaging in Abdominal Malignancies
Role of Multiparametric MR Imaging in Malignancies of the Urogenital Tract
Functional MR Imaging in Gynecologic Cancer
Multiparametric MR Imaging of Breast Cancer
Assessment of Musculoskeletal Malignancies with Functional MR Imaging
Therapy Monitoring with Functional and Molecular MR Imaging
MAGNETIC RESONANCE IMAGING CLINICS OF NORTH AMERICA
FORTHCOMING ISSUES
May 2016
August 2016
November 2016
RECENT ISSUES
November 2015
August 2015
May 2015
PROGRAM OBJECTIVE
TARGET AUDIENCE
LEARNING OBJECTIVES
ACCREDITATION
DISCLOSURE OF CONFLICTS OF INTEREST
UNAPPROVED/OFF-LABEL USE DISCLOSURE
TO ENROLL
METHOD OF PARTICIPATION
CME INQUIRIES/SPECIAL NEEDS
Foreword: Functional MR Imaging in Oncology
Preface: MR Imaging Pushes Radiologists to Move Forward in Oncologic Imaging
Functional MR Imaging Techniques in Oncology in the Era of Personalized Medicine
Key points
INTRODUCTION
DIFFUSION-WEIGHTED IMAGING
DYNAMIC CONTRAST-ENHANCED MR IMAGING AND MR CONTRAST AGENTS
Perfusion Imaging
Hepatobiliary Contrast Agents
Superparamagnetic Particles of Iron Oxide
Other MR Imaging Agents
IMAGING OF TUMOR METABOLITES USING "TRADITIONAL" MAGNETIC RESONANCE SPECTROSCOPY/SPECTROSCOPIC IMAGING AND DYNAMIC NUCLEAR ...
"Traditional" Magnetic Resonance Spectroscopy
Dynamic Nuclear Polarization (Hyperpolarization)
SUMMARY: FUNCTIONAL MR IMAGING TODAY AND TOMORROW
REFERENCES
MR Imaging Biomarkers in Oncology Clinical Trials
Key points
INCORPORATING QUANTITATIVE MR IMAGING IN CLINICAL TRIALS
CURRENT USE OF MR IMAGING FOR CLINICAL TRIALS
QUANTITATIVE MR IMAGING TECHNIQUES CURRENTLY AVAILABLE FOR CLINICAL TRIALS
Dynamic Susceptibility Contrast MR Imaging
Dynamic Contrast-Enhanced MR Imaging
Diffusion-Weighted Imaging
EMERGING MR IMAGING METHODS FOR CANCER
Chemical Exchange Saturation Transfer MR Imaging
Hyperpolarized MR Imaging
Magnetic Resonance Elastography
Multiparameter MR Imaging Methods
SUMMARY
ACKNOWLEDGMENTS
REFERENCES
Body Diffusion-weighted MR Imaging in Oncology
Key points
INTRODUCTION
BODY DIFFUSION-WEIGHTED IMAGING AT 3.0 TESLA: ADVANTAGES AND DISADVANTAGES
TECHNICAL IMPLEMENTATION OF BODY DIFFUSION-WEIGHTED IMAGING AT 3.0 TESLA
Magnetic Resonance Shimming
Reduced-field-of-view Imaging
Readout-segmented Echo-planar Imaging
CLINICAL APPLICATIONS OF BODY DIFFUSION-WEIGHTED IMAGING FOR ONCOLOGY AT 3.0 TESLA
Disease Detection
Disease Characterization
Assessment of Tumor Response to Treatment
Whole-body Diffusion-weighted Imaging
DIFFUSION-WEIGHTED IMAGING ON A HYBRID PET-MR IMAGING SYSTEM
SUMMARY
ACKNOWLEDGMENT
REFERENCES
Assessment of Tumor Angiogenesis
Key points
INTRODUCTION
KEY METHODOLOGICAL DECISIONS
CLINICAL APPLICATIONS
Imaging Primary Breast Tumors
Malignant breast lesion detection with dynamic contrast-enhanced MR imaging
Screening in high-risk populations with dynamic contrast-enhanced MR imaging
Dynamic contrast-enhanced MR imaging-based early assessment of response to chemotherapy
Imaging Tumor Foci Within the Prostate Gland
Lesion detection and localization with dynamic contrast-enhanced MR imaging
Targeting biopsy and dose painting with functional imaging
RESEARCH APPLICATIONS
Showing Proof of Mechanism with Dynamic Contrast-enhanced MR Imaging
Dynamic Contrast-enhanced MR Imaging as a Decision-making Tool in the Phase I and II Arena
Prognostic and Predictive Dynamic Contrast-enhanced MR Imaging Biomarkers: Indicators of Outcome
SUMMARY
ACKNOWLEDGMENTS
REFERENCES
Clinical Imaging of Tumor Metabolism with 1H Magnetic Resonance Spectroscopy
Key points
INTRODUCTION
Physical Bases
Clinical Information
ACQUISITION PREPARATION
SPATIAL ENCODING
ACQUISITION PARAMETERS
MAGNETIC RESONANCE SPECTROSCOPY SIGNAL QUANTIFICATION
CLINICAL APPLICATIONS IN ONCOLOGY
1H Magnetic Resonance Spectroscopy of the Central Nervous System in a Clinical Setting
Technical considerations in brain spectroscopy
Physiopathology and clinical relevance of the main spectra metabolites
Surgical planning, prognosis, and therapeutic considerations
Oncologic Applications of 1H Magnetic Resonance Spectroscopy Outside the Brain
Prostate magnetic resonance spectroscopy
Technique
Metabolites
Breast magnetic resonance spectroscopy
Clinical experience with 1H magnetic resonance spectroscopy in abdominal tumors
1H magnetic resonance spectroscopy in gynecologic malignancies
1H magnetic resonance spectroscopy of testicular tumors
1H magnetic resonance spectroscopy of colorectal cancer
1H magnetic resonance spectroscopy of soft tissue and bone tumors
1H magnetic resonance spectroscopy of head and neck tumors
SUMMARY
REFERENCES
Multiparametric MR Imaging in the Assessment of Brain Tumors
Key points
INTRODUCTION
IMAGING BIOMARKERS
PERFUSION MR IMAGING
IMMUNOHISTOCHEMISTRY CORRELATES OF PERFUSION IMAGING
CLINICAL APPLICATIONS
Differential Diagnosis of Solitary Brain Lesions
Tumor Grading
Guiding Stereotactic Biopsy and Radiosurgery
Assessing Tumor Extension
Monitoring Therapeutic Response
Tumor recurrence versus radiation necrosis
Pseudoresponse
Prognosis
DIFFUSION-WEIGHTED IMAGING AND DIFFUSION TENSOR IMAGING
CLINICAL APPLICATIONS
Differential Diagnosis of Cerebral Neoplasms
Tumor grading
Guiding Stereotactic Biopsy and Radiosurgery
Preoperative planning and evaluation of tumor extension
Monitoring Therapeutic Response
Postsurgery evaluation
Posttreatment Evaluation
Pseudoprogression
Pseudoresponse
Prognosis
1H MAGNETIC RESONANCE SPECTROSCOPY
CLINICAL APPLICATIONS OF SPECTROSCOPY
Differential Diagnosis of Cerebral Tumors
Tumor grading
Assess tumor extension
Guiding Stereotactic Biopsy and Radiosurgery
Monitoring Therapeutic Response
Posttreatment evaluation
Prognosis
PREOPERATIVE PLANNING
SUMMARY
REFERENCES
Evaluation of Head and Neck Tumors with Functional MR Imaging
Key points
DISCUSSION OF PROBLEM/CLINICAL PRESENTATION
Diffusion
Perfusion
Outline
IMAGING PROTOCOLS
Diffusion-Weighted MR Imaging
Data acquisition
Diffusion-weighted MR imaging data processing
Dynamic Contrast-Enhanced MR Imaging Data Acquisition
Dynamic contrast-enhanced MR imaging data processing
Dynamic contrast-enhanced MR imaging data quantification
Arterial Spin Labeling MR Imaging Data Acquisition
Arterial spin labeling data quantification
Advanced data analysis
IMAGING FINDINGS
Tumor Characterization and Differentiation
Tumor Risk Stratification and Staging
Monitoring of Treatment Response
Prediction of Treatment Response
PEARLS, PITFALLS, AND VARIANTS
SUMMARY
REFERENCES
Functional MR Imaging in Chest Malignancies
Key points
INTRODUCTION
FUNCTIONAL MR IMAGING IN THE CHEST: TECHNICAL CONSIDERATIONS
Diffusion-Weighted Imaging
Dynamic Contrast-Enhanced-MR Imaging
FUNCTIONAL MR IMAGING OF THE LUNG
Pulmonary Nodule Detection and Characterization
Functional MR imaging and pulmonary nodule detection
Diffusion-weighted imaging and pulmonary nodule characterization
Dynamic contrast-enhanced-MR imaging and pulmonary nodule characterization
Lung Cancer Staging and Assessment of Resectability
T staging of non-small cell lung cancer
N staging of non-small cell lung cancer
M staging of non-small cell lung cancer
Treatment Monitoring and Follow-up
FUNCTIONAL IMAGING OF THE PLEURA
Differentiation of Benign Versus Malignant Pleural Lesions
Malignant Pleural Conditions: Staging and Treatment Monitoring
Malignant pleural mesothelioma staging
Treatment monitoring and prognostic factors
Benign Pleural Conditions: Potential Pitfalls
Functional MR Imaging and Mediastinal Masses
FUNCTIONAL IMAGING OF CARDIAC AND PERICARDIAL TUMORS
FUNCTIONAL IMAGING OF CHEST WALL TUMORS
SUMMARY
REFERENCES
Multiparametric MR Imaging in Abdominal Malignancies
Key points
INTRODUCTION
DIFFUSION-WEIGHTED MR IMAGING
Technical Aspects of Diffusion-Weighted Imaging
Sequence design
Modeling of diffusion signal
b-values selection
Clinical Applications of Diffusion-Weighted Imaging
Liver
Lesion detection
Lesion characterization
Hepatocellullar nodules in cirrhosis
Therapy monitoring
Biliary system and gallbladder malignancies
Pancreatic cancer and other pancreatic tumors
PERFUSION MR IMAGING
Technical Design of Perfusion MR Imaging of Upper Abdomen
Image acquisition
Data analysis
Clinical Applications of Dynamic Contrast-Enhanced-MR Imaging
Liver
Pancreas
Cholangiocarcinoma
ARTERIAL SPIN LABELING
1H-MAGNETIC RESONANCE SPECTROSCOPY
MAGNETIC RESONANCE ELASTOGRAPHY
HEPATOBILIARY CONTRAST AGENTS
MULTIPARAMETRIC IMAGING
SUMMARY
REFERENCES
Role of Multiparametric MR Imaging in Malignancies of the Urogenital Tract
Key points
INTRODUCTION
MULTIPARAMETRIC MR IMAGING-TECHNIQUES
T2-Weighted Sequences
T1-Weighted Sequences
Contrast-Enhanced Imaging
Kidney
Ureter
Bladder
Prostate
Diffusion-Weighted Imaging
Arterial Spin-Labeled MR imaging
Blood Oxygen Level-Dependent MR Imaging
Magnetic Resonance Spectroscopy
CLINICAL APPLICATIONS
Kidney
Mass characterization and subtyping of renal cell carcinoma
Evaluation for therapeutic response in metastatic renal cell carcinoma
Ureter and Collecting System
Bladder
Prostate
Standardization
SUMMARY
REFERENCES
Functional MR Imaging in Gynecologic Cancer
Key points
INTRODUCTION
ENDOMETRIAL CANCER
Detection
Staging
Characterization and Prognostication
Monitoring Treatment Response
Follow-up and Detection of Recurrent Disease
CERVICAL CANCER
Detection
Staging
Characterization and Prognostication
Assessment of Treatment Response
Follow-up and Detection of Disease Recurrence
OVARIAN CANCER
Detection
Staging Accuracy and Predicting Surgical Cytoreduction
Characterization
Monitoring Treatment Response
Detecting Disease Recurrence
SUMMARY
REFERENCES
Multiparametric MR Imaging of Breast Cancer
Key points
INTRODUCTION
BREAST MR IMAGING PARAMETERS
Dynamic Contrast-Enhanced MR Imaging
Morphology
Dynamic contrast-enhanced kinetic enhancement features
Promising clinical applications of quantitative dynamic contrast-enhanced MR imaging
Technical challenges and considerations of quantitative dynamic contrast-enhanced MR imaging
Diffusion-Weighted MR Imaging
Apparent diffusion coefficient calculation
Promising clinical applications of breast diffusion-weighted imaging
Technical challenges of breast diffusion-weighted imaging
Advanced methods of breast diffusion-weighted imaging
Magnetic Resonance Spectroscopy
Promising clinical applications of breast magnetic resonance spectroscopy
Technical challenges of breast magnetic resonance spectroscopy
Advanced methods of breast magnetic resonance spectroscopy
Emerging Functional Breast MR imaging Approaches
Sodium MR imaging
Blood oxygen level-dependent MR imaging
SUMMARY
REFERENCES
Assessment of Musculoskeletal Malignancies with Functional MR Imaging
Key points
INTRODUCTION
FUNCTIONAL MR IMAGING TECHNIQUES
Chemical Shift Imaging
Diffusion-weighted MR Imaging
Magnetic Resonance Spectroscopic Imaging
Dynamic Contrast-enhanced Perfusion MR Imaging
DIAGNOSIS
Bone Marrow Malignancy
Characterization
Soft tissue tumors
Bone tumors
STAGING
POSTTREATMENT EVALUATION
Preoperative Treatment Response
Posttherapy Follow-up
SUMMARY
REFERENCES
Therapy Monitoring with Functional and Molecular MR Imaging
Key points
INTRODUCTION
MR IMAGING TECHNIQUES FOR THE EVALUATION OF TUMOR PHENOTYPE
TUMOR RESPONSE ASSESSMENT USING MR IMAGING
Conventional Oncologic Therapies: Chemotherapy and Radiotherapy
Targeted Therapies
Tumor angiogenesis: antiangiogenic and antivascular therapies
Targeted therapies blocking tumor proliferation and metabolism
Anti-epidermal growth factor receptor/HER2 drugs
Anti-anaplastic lymphoma kinase drugs
Drugs inhibiting c-KIT pathway
Pathways mediating downstream effects of epidermal growth factor receptor, anaplastic lymphoma kinase, and c-KIT
Tumor invasiveness
Hormonal Therapy
Immunotherapy
Interventional Techniques
Other Therapeutic Agents in Cancer
ONCOLOGIC-RELATED IMAGING FINDINGS
Bone-Targeted Therapies
Imaging Drug Side Effects
MULTIPARAMETRIC IMAGING OF TUMOR RESPONSE
FUTURE DIRECTIONS
SUMMARY
REFERENCES
Index

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