1. Overview
2. Origins of the Osteoclast
3. Trafficking of Osteoclast Precursors
4. Osteoclast Biology: Regulation of Formation and Function
5. Osteoblasts and the Immune system
6. Osteocyte Biology
7. Bone Cells and the Hematopoietic Niche
8. The Function of RANKL Beyond the Osteoclast
9. The Effects of Immune Cell Products (Cytokines and Hematopoietic Cell Growth Factors) on Bone Cells
10. Coupling Between Immune and Bone Cells
11. The Role of the Immune System in the Development of Osteoporosis and Fracture Risk
12. The Role of Sex Steroiods in the Interactions of the Immune System with Bone
13. The Role of the Immune System in the Local and Systemic Bone Loss of Inflammatory Arthritis
14. Osteoarthritis and the Immune System
15. Inflammatory Bowel Disease and Bone
16. The Role of the Immune System and Bone Cells in Acute and Chronic Osteomyelitis
17. The Role of the Immune System in Fracture Healing
18. The Role of the Immune System in the Effects of Cancer on Bone
19. Osteoimmunology in the Oral Cavity (Periodontal Disease, Lesions of Endodontic Origin and Orthodontic Tooth Movement)
20. The Role of the Immune System in the Interactions of Fat and Bone
List of Contributors
Antonios O. Aliprantis MD, PhD, Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
Sheila N. Bello-Irizarry PhD, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA
Ryan Berry PhD, Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, USA
Karine Briot MD, PhD, Department of Rheumatology, INSERM U1153, Paris Descartes University, Cochin Hospital, Paris, France
Julia F. Charles MD, PhD, Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
Yongwon Choi PhD, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
John L. Daiss PhD, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA
Jean-Michel Dayer MD, Faculty of Medicine, Centre Medical Universitaire, Geneva, Switzerland
Karen L. de Mesy Bentley BS, MS
Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA
Thomas A. Einhorn MD, Department of Orthopaedic Surgery, Boston University School of Medicine, Boston, MA, USA
Roberta Faccio PhD, Department of Orthopedics, Washington University in St. Louis School of Medicine, Saint Louis, MO, USA
Jackie A. Fretz PhD, Comparative Medicine and Molecular, Cellular and Developmental Biology, Yale School of Medicine, New Haven, CT, USA
Gustavo P. Garlet DDS, MS, PhD, Department of Biological Sciences, School of Dentistry of Bauru, University of Sao Paulo, Bauru, Brazil
Louis C. Gerstenfeld PhD, Department of Orthopaedic Surgery, Boston University School of Medicine, Boston, MA, USA
Piet Geusens MD, PhD, Department of Internal Medicine, Subdivision of Rheumatology, Maastricht University Medical Center, Maastricht, The Netherlands
Mary B. Goldring PhD, The Hospital for Special Surgery and Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY, USA
Steven R. Goldring MD, The Hospital for Special Surgery and Department of Medicine, Weill Cornell Medical College, New York, NY, USA
Ellen M. Gravallese MD, Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, USA
Dana T. Graves DDS, DMSc, Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA
Danka Grcevic MD, PhD, Department of Physiology and Immunology, University of Zagreb School of Medicine, Zagreb, Croatia
Mark C. Horowitz PhD, Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, USA
Masaru Ishii MD, PhD
Department of Immunology and Cell Biology, Graduate School of Medicine, Osaka University, Osaka
CREST, Japan Science and Technology Agency, Tokyo, Japan
Rayyan A. Kayal BDS, DSc, Department of Periodontics, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia
Junichi Kikuta MD, PhD
Department of Immunology and Cell Biology, Graduate School of Medicine, Osaka University, Osaka
CREST, Japan Science and Technology Agency, Tokyo, Japan
Anne Klibansky MD, Department of Medicine, Neuroendocrinology, Massachusetts General Hospital, Boston, MA, USA
Natasa Kovacic MD, PhD, Department of Anatomy, University of Zagreb School of Medicine, Zagreb, Croatia
Henry M. Kronenberg MD, Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Sun-Kyeong Lee PhD, Department of Medicine, UCONN Center on Aging, University of Connecticut Health Center, Farmington, CT, USA
Joseph Lorenzo MD, Department of Medicine and Orthopaedics, University of Connecticut Health Center, Farmington, CT, USA
Ormond MacDougald PhD, Departments of Molecular and Integrative Physiology and Internal Medicine (Metabolism, Endocrinology & Diabetes Division), University of Michigan School of Medicine, Ann Arbor, MI, USA
T. John Martin MD, DSc
St. Vincent's Institute of Medical Research, Fitzroy
Department of Medicine, St. Vincent's Hospital, Melbourne, The University of Melbourne, Fitzroy, Victoria, Australia
Mary C. Nakamura MD
Department of Medicine, Division of Rheumatology, University of California, San Francisco
Arthritis/Immunology Section, Veterans Administration Medical Center, San Francisco, CA, USA
Mark S. Nanes MD, PhD
Veterans Affairs Medical Center and Division of Endocrinology, Metabolism, and Lipids
Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
Erin Nevius PhD, Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
Kohei Nishitani MD, PhD, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA
Charles A. O'Brien PhD, Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences; the Central Arkansas Veterans Healthcare System, Little Rock, AR, USA
Thomas Oates DMD, PhD, Department of Periodontics, University of Texas Health Science Center, San Antonio, TX, USA
Josef Martin Penninger MD, Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna, Austria
João P. Pereira PhD, Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
Julian M.W. Quinn PhD, The Garvan Institute, Darlinghurst, New South Wales, Australia
Matthew S. Rodeheffer PhD, Comparative Medicine and Molecular, Cellular and Developmental Biology, Yale School of Medicine, New Haven, CT, USA
Garson David Roodman MD, PhD, Division of Hematology Oncology, Indiana University School of Medicine, Indianapolis, IN, USA
Clifford J. Rosen MD, The Center for Clinical and Translational Research, Maine Medical Center Research Institute, Scarborough, ME, USA
Christian Roux MD, PhD, Department of Rheumatology, INSERM U1153, Paris Descartes University, Cochin Hospital, Paris, France
Georg Schett MD, Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
Edward M. Schwarz PhD
Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester
Department of Pathology and...