Neurobiology of Depression

Animal Models of Depression. Neurophysiological and Neuropsychological Models of Depression. Neural Foundations of Major Depression: Classical Approaches and New Frontiers. Genetic Regulation of Emotion Brain Circuitries. Development of Brain Monoaminergic Systems. Contribution of Pharmacology to Development of Monoaminergic Hypotheses of Depression. Serotonergic Pathways in Depression. Noradrenergic System in Depression. Glutamatergic System and Mood Disorders. Role of the Endocannabinoid System in Etiopathology of Major Depression. Opioid System and Depression. Chronobiological Rhythms, Melatonergic System, and Depression. Corticotropin-Releasing Factor and Hypothalamic-Pituitary-Adrenal Axis Regulation of Behavioral Stress Response and Depression. Depression and Cytokine-Regulated Pathways. Tachykinins and Tachykinin Receptor Antagonists in Depression: Therapeutic Implications. Role of Neuropeptide Y in Depression: Current Status. Nitric Oxide Signaling in Depression and Antidepressant Action. Beta-Arrestins in Depression: A Molecular Switch from Signal Desensitization to Alternative Intracellular Adaptor Functions. Brain-Derived Neurotrophic Factor and Major Depression. Role of Cyclic Nucleotide Phosphodiesterases in Depression and Antidepressant Activity. Vascular Depression: A Neuropsychological Perspective. Neurobiological Basis for Development of New Antidepressant Agents. Index.