Nervous System Drug Delivery: Principles and Practice helps users understand the nervous system physiology affecting drug delivery, the principles that underlie various drug delivery methods, and the appropriate application of drug delivery methods for drug- and disease-specific treatments. Researchers developing nervous system putative therapeutic agents will use this book to optimize drug delivery during preclinical assessment and to prepare for regulatory advancement of new agents. Clinicians will gain direct insights into pathophysiologic alterations that impact drug delivery and students and trainees will find this a critical resource for understanding and applying nervous system drug delivery techniques.
- Offers an up-to-date, comprehensive resource on drug delivery to the nervous system
- Provides a bridge for understanding across nervous system delivery-related physiology, drug delivery principles. and the methodologies that underlie the various methods of drug distribution (with clinical application)
- Written for a broad audience of researchers, clinicians and advanced graduate students in neuroscience, neurology, neurosurgery, pharmacology, radiology and psychiatry
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
ISBN-13
978-0-12-813998-1 (9780128139981)
Schweitzer Klassifikation
Section I. Physiology of Nervous System Drug Delivery1. Fundamentals of Brain-Barrier Anatomy and Global Functions2. Blood-Brain Barrier in Disease States 3. Pharmacokinetics of Systemic Drug Delivery4. Pharmacokinetics of Drug Delivery Past the Blood-Brain Barrier5. Anatomy and Physiology of Cerebrospinal fluid Dynamics 6. Pharmacokinetics of Polymeric Drug Delivery 7. Pharmacokinetic Models of Convection-Enhanced Drug Delivery8. Mechanisms and Clinical Applications of Stem Cell Therapy
Section II. Nervous System Drug Delivery Techniques9. Intravenous and Intravascular Drug Delivery10. Blood-Brain Barrier Disruption 11. Ultrasonic Methods 12. Nanoparticles for Brain Tumor Delivery13. Solute Transport in the Cerebrospinal Fluid: Physiology and Practical Implications14. Drug-impregnated Polymer Delivery 15. Immunomodulatory Methods 16. Convection-Enhanced Drug Delivery in the Central Nervous System17. Stem Cell Transplantation for Neurological Disease: Technical Considerations and Delivery Devices 18. CRISPR-Cas Gene Editing for Neurological Disease
Section III. Clinical Application of Nervous System Drug Delivery19. Drug and Disease-Specific Paradigms for Drug Delivery to the Central Nervous System20. Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Brain Tumors21. Clinical Methods of Nervous System Drug Delivery for Tumors22. Delivery Methods for Treatment of Genetic Disorders23. Direct Convective of Nervous System Drug Delivery for Patients with Neurodegenerative Disorders24. Central Nervous System Drug Delivery after Ischemic or Hemorrhagic Stroke25. Intrathecal Drug Delivery for Cancer Pain
