Quantitative Biology of Metabolism

1. Models of Metabolism.- 1.1. Models in General.- 1 The Epistemological Significance of Models in Science.- 2 Causality, Complexity and Computers.- 1.2. Discrete and Continuous Models.- 3 Discrete and Continuous Representations of Metabolic Models.- 4 Interaction of a Digital (Genetic) System with a Continuous (Enzymatic) One in the Cell.- 5 A Model for Sustained Rhythmic Binary Logic in Biochemical Systems.- 1.3 Stochastic and Deterministic Models.- 6 Some General Ideas on Deterministic and Stochastic Models in Biological Systems.- 7 Turnover Compartmentalization. An Approach to Analysis of Whole-body Retention Data.- 1.4 Computer Models of Cell Metabolism.- 8 Functioning of a Cell Model.- 9 A Digital Computer System for the Construction and Analysis of Steady State Models of Enzyme Catalysed Networks.- 10 Computation of Equilibria and Kinetics of Chemical Systems with Many Species.- 2. Metabolic Parameters.- 2.1 Temperature - Season - Adaptation.- 11 The Relation between Heat Production, Oxygen Consumption and Temperature in Some Poikilotherms.- 12 On Structure and Metabolic Rate of the Skeletal Muscle of the Eel (Anguilla vulgaris L.).- 13 Analysis of Heart Rate Adaptation to Temperature.- 14 The Heat Production of Goldfinches and Canaries in Summer and Winter.- 15 Quantitative Thermogenesis of Brown Fat in Hibernation and Cold Adaptation.- 2.2 Growth - Age.- 16 Contributions to the Energetics of Animal Growth.- 17 Models of the Growth of Organisms under Nutrient Limiting Conditions.- 18 Biomathematical Interpretation of Organismic Growth.- 19 Relationships between Respiration during Imbibition and Subsequent Growth Rates in Germinating Seeds.- 20 Quantitative Parameters of Rat Liver Mitochondria in Relation to Age.- 2.3 Cellular Milieu - ExperimentalInfluences.- 21 Enzymes as Indicators of Intracellular Reaction Conditions.- 22 The Influence of Ethanol on Carbohydrate- and Fat-Metabolism of the Liver.- 3. Damage to Metabolism.- 3.1 Damage Due to Irradiation.- 23 Application of Quantitative Models for the Analysis of the Mechanisms of Protection against the Damaging Effects of Ionizing Radiation.- 24 Intracellular Recovery after Irradiation.- 3.2 Damage Due to Radio lytic or Toxic Compounds.- 25 Inhibitory Action of Radiolytic Compounds on Cell Function.- 26 On the Release and Elimination of Liver Glutamic-Oxalacetic-Transferase.- 3.3 Damage Due to Oxygen Lack.- 27 Metabolic Effects of Acute Hypoxia on Rat and Turtle Brain.- 28 Changes in Metabolite Concentrations in Ischemic Kidneys of Rabbits and in Transplanted Kidneys of Dogs.- 4. Metabolic Control.- 4.1 Metabolic Control and Optimisation.- 29 The Mutual Coaction of two Regulatory Mechanisms Realizing Optimal Autoregulation of Metabolism.- 30 Optimization of Structure and Metabolism in Cellular Automata.- 4.2 Metabolic Control at the Cellular Level.- 31 Oscillatory Control of Glycolysis as a Model for Biological Timing Processes.- 32 Evaluation of the Coordinated Control of Activated Glycolysis and Respiration by Ortho-phosphate and ADP in Ascites Tumor Cells.- 33 Profiles of Substrate Levels of the Central Metabolic Pathways in Frog Heart.- 4.3 Control at the Systemic Level.- 34 Analysis by Computer of Some Oscillatory Features of the Red Cell System.- 4.4 Control and CNS.- 35 Memory and Cellular Control Processes.- 36 On the Steady State Nature of Evolution, Learning, Perception, Hallucination and Dreaming.- 37 Circadian Activity Rhythm in the CNS and its Control.- 4.5 Thermoregulation.- 38 The Use of Theoretical Models in the Study of Thermoregulation in Man.- 39 On the Mechanism of the Calorigenic Action of Catecholamines.- 5. Conclusion.- 40 Some Epicritical Remarks (Instead of a Summary).- Author Index.