Chemical Approaches to the Synthesis of Peptides and Proteins

Introduction, Amino Acids and Peptide and Protein Structure, Amino Acid Activation and Coupling, Protection Schemes for Peptide Synthesis, The Synthesis of Peptides, Solid-Phase Peptide Synthesis, The Solid Support, Protection Schemes, Attachment of the First Amino Acid to the Solid Support, Chain Elongation, Cleavage of the Peptide from the Resin, Examples of Protein Synthesis by Linear SPPS, Peptide Synthesis in Solution, Strategic Considerations, Protection Schemes, Chain Elongation, Final Removal of Protecting Groups, Special Approaches to the Synthesis of Peptides in Solution, Examples of Peptide Synthesis in Solution, Convergent Approaches to the Synthesis of Large Peptides and Proteins, Convergent Solid-Phase Peptide Synthesis, The Coupling of Protected Peptide Segments in Solution, Coupling of Minimally Protected Peptides in Aqueous Solution, Chemical Ligation of Peptide Segments, Formation of Disulfide Bridges, Peptides with Disulfide Bridges, Protection of Cysteine in Peptide Synthesis, Chemical Methods for the Formation of Disulfide Bridges, Regioselective Disulfide Bridge Formation, Peptide Libraries, Multiple Peptide Synthesis in Parallel, Peptide Library Techniques, Examples of Peptide Library Synthesisi, Each chapter contains References