Flow Cytometry in Drug Discovery and Development
Erschienen am 20. April 2011
360 Seiten
978-0-470-92278-1 (ISBN)
Beschreibung
This book covers the unique application of flow cytometry in drug discovery and development. The first section includes two introductory chapters, one on flow cytometry and one on biomarkers, as well as a chapter on recent advances in flow cytometry. The second section focuses on the unique challenges and added benefits associated with the use of flow cytometry in the drug development process. The third section contains a single chapter presenting an in depth discussion of validation considerations and regulatory compliance issues associated with drug development.
Rezensionen / Stimmen
"Flow Cytometry in Drug Discovery and Development is a monographwhich comprehensively addresses the technical aspects of flowcytometry applied to drug development. Readers will learn howthe unique benefits of this powerful analytical technique can berealized in the drug development process." (Analytical andBioanalytical Chemistry, 29 July 2012)"This book covers the unique application of flow cytometry in drugdiscovery and development." (Smart Grid, 15 February 2011)Weitere Details
Weitere Ausgaben
Andere Ausgaben
Virginia Litwin | Philip Marder
Flow Cytometry in Drug Discovery and Development
Buch
12/2010
Wiley
144,50 €
Artikel ist vergriffen; siehe Neuauflage
Virginia Litwin | Philip Marder
Flow Cytometry in Drug Discovery and Development
Software
10/2010
Wiley
139,23 €
Keine Lieferinformation verfügbar
Personen
Virginia Litwin is a Principal Scientist at Covance CentralLaboratory Services. After numerous years in thepharmaceutical/biotechnology industry, she has become a leader inthe application and validation of flow cytometric methods in drugdiscovery and development. She founded the Flow CytometrySubcommittee of the Ligand Binding Assay Bioanalytical Focus Groupwithin the American Association of Pharmaceutical Scientists(AAPS). She is an active contributor to the International ClinicalCytometry Society (ICCS) and the International Society forAnalytical Cytology (ISAC). She received her bachelor's from theUniversity of California and her doctorate from the University ofIowa.
Philip Marder was internationally distinguished for hisleadership in the application of flow cytometry in early drugdiscovery and development. He was a key contributor to thescientific community as an active member of ISAC and AAPS. Afterreceiving both his bachelor's and master's degrees from The OhioState University, he had a distinguished thirty year career at EliLilly and Company.
Inhalt
Preface.
Foreword.
Acknowledgements.
Contributors.
Part I Introduction (Philip Marder and VirginiaLitwin).
1 Introduction to Flow Cytometry (Elizabeth Raveche, FatimaAbbasi, Yao Yuan, Erica Salerno, Siddha Kasar and GeraldMarti).
2 Recent Advances in Flow Cytometry: Platforms, Tools and theChallenges for Data Analysis (Paul J Smith, Roy Edward, Rachel JErrington).
3 Introduction to Biomarkers (Ole Vesterqvist and ManjulaReddy).
Part II Flow Cytometry in the Drug Development Process(Virginia Litwin and Philip Marder).
4 HTS Flow Cytometry, Small Molecule Discovery, and the NIHMolecular Libraries Initiative (Larry A. Sklar and Bruce S.Edwards).
5 A Multiparameter Approach to Cell Cycle Analysis as a StandardTool in Oncology Drug Discovery (Carmen Raventos-Suarez andByron H. Long)
6 Flow Cytometry in Pre-Clinical Toxicology/Safety AssessmentEnvironment (David McFarland and Kristi Harkins)
7 Use of Flow Cytometry for Defining and Validating theMolecular Mechanism of Anti-cancer Drugs in Humans (David WHedley).
8 CD4 T cell Assessments in Evaluation of HIV Therapeutics(Thomas N. Denny, Raul Louzao, John Wong and BrookeWalker).
9 A Translational Medicine Approach to Monitoring the ImmuneSystem during Clinical Trials (Virginia Litwin and JamesAndahazy).
10 Immunogenicity Testing Using Flow Cytometry (Denise M.O'Hara and Valerie Theobald).
11 Pharmacokinetics by Flow Cytometry: Recommendations forDevelopment and Validation of Flow Cytometric Method forPharmacokinetic Studies (Yuanxin Xu and Susan MRichards).
Part III Validation and Regulatory Compliance (VirginiaLitwin and Philip Marder).
12 Regulatory Compliance and Method Validation (CarlaHill, Dianna Wu, John Ferbas, Virginia Litwin, ManjulaReddy).
13 Instrument Validation for Regulated Studies (John Ferbasand Michelle Schroeder).
Part IV Future Directions (Virginia Litwin and PhilipMarder).
14 Probability State Modeling: A New Paradigm for CytometricAnalysis (Bruce Bagwell).
15 Phospho Flow Cytometry: Single Cell Signaling Networks inNext Generation Drug Discovery and Patient Stratification (PeterO. Krutzik, Sean C. Bendall, Matthew B. Hale, Jonathan M. Irish,Garry P. Nolan).
Index.
