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Provides detailed and up-to-date coverage of analytical approaches for biologic drug modalities
The development of innovative biologic therapies has revolutionized medicine, but their complexity demands equally advanced analytical approaches. Characterizing Biotherapeutics: Analytical Methods for Diverse Modalities introduces the tools and techniques used to analyze these groundbreaking therapies. Designed to help readers characterize and troubleshoot increasingly diverse and sophisticated therapeutic molecules, this in-depth guide addresses different biologic drugs, their unique analytical challenges, and the methods that enable their analysis.
Organized into two comprehensive sections, Characterizing Biotherapeutics first delves into the fundamentals of analytical platforms, providing a robust foundation in techniques such as mass spectrometry and biophysical assays. The second section applies these methods to real-world scenarios, focusing on drug discovery, clinical evaluation, and commercial considerations in drug development. Authors Jennie R. Lill and Wendy Sandoval provide clear guidance tailored to the evolving demands of therapeutic innovations such as structural characterization, high-throughput biophysical assays, and RNA-based therapeutics.
Equipping researchers with the knowledge to navigate the challenges posed by increasingly complex biologics, Characterizing Biotherapeutics: Analytical Methods for Diverse Modalities:
Characterizing Biotherapeutics: Analytical Methods for Diverse Modalities is an essential reference for analytical scientists, biologists, and mass spectrometrists involved in biomolecule analysis. It is also a valuable resource for graduate students taking advanced courses in biotechnology, drug development, and biotherapeutic analysis, as well as professionals in biotechnology and pharmaceutical industries working to advance biotherapeutic research and development.
Jennie R. Lill, PhD, is the Executive Director of the Proteomic and Genomic Technologies Department at Genentech, where she has worked since 2004. With over 90 peer-reviewed publications and three books, including Analytical Characterization of Biotherapeutics, her work focuses on cutting-edge analytical techniques in drug discovery and development.
Wendy Sandoval was the Director of Translational Mass Spectrometry in Research at Genentech, where she had been a pivotal contributor for over 30 years. She has authored more than 100 scientific publications and co-authored two books, including Analytical Characterization of Biotherapeutics. She now runs a plant nursery and botanical garden in Northern California (https://botanicanurseryandgardens.com/) and enjoys playing in dirt.
Corey E. Bakalarski
Proteomic and Genomic Technologies
Genentech Inc.
South San Francisco, CA
USA
Mercedesz Balasz
Biochemical and Cellular Pharmacology
Genentech
South San Francisco
CA, USA
Marcus Bantscheff
Target Discovery, GSK
Heidelberg
Germany
and
Research and Early Development
Roche Pharma
Basel
Switzerland
Hayley M. Bennett
Department of Proteomic and Genomic Technologies
Genentech Research and Early Development
Maureen Beresini
Department of Biochemical and Cellular Pharmacology
Tess Branon
Proteomic & Genomic Technologies Department
Ashley Byrne
Julien Camperi
Cell Therapy Engineering and Development
Shengya Cao
Development
Inceptive
Palo Alto, CA
Naincy R. Chandan
Discovery Technology
Nurix Therapeutics, Inc.
San Francisco, CA
Jieming Chen
gRED Computational Sciences
Sivan Cohen
Bioanalytical Sciences
Genentech, Inc.
Phillip Chu
Michael Dillon
Department of Antibody Engineering
H. Christian Eberl
Alberto Estevez
Thomson Instrument Company
Carlsbad, CA
Amin Famili
Department of Synthetic Molecule Analytical Chemistry
Abel Ferrel
Independent Researcher
Emily Freund
Department of Molecular Biology
Manasi Gaikwad
Center for Mass Spectrometry and Optical Spectroscopy (CeMOS)
Mannheim University of Applied Sciences
Mannheim
Carolina Galan
Amy Gilbert
Adaptive Biotechnologies
Seattle, WA
Alissa D. Guarnaccia
Axel Guilbaud
Protein Analytical Chemistry
Albert J.R. Heck
Biomolecular Mass Spectrometry and Proteomics
Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences
University of Utrecht
Utrecht
The Netherlands
Netherlands Proteomics Center
Suk-Joon Hyung
Saeed Izadi
Pharmaceutical Development
Eric Janezic
Christine C. Jao
Department of Structural Biology
Hiruni S. Jayasekera
Department of Chemistry and Biochemistry
The University of Arizona
Tucson, AZ
Robert S. Jones
Drug Metabolism and Pharmokinetics
S. Cyrus Khojasteh
Sascha Knecht
Felix Kuhne
Analytical Characterization, Pharma Technical Development
Roche Diagnostics GmbH
Penzberg
M. Violet Lee
Paola Di Lello
Dennis H. Leung
Amritha Lewis
Yinyin Li
Jennie R. Lill
Rachel P. Liu
T. Noelle Lombana
ReCode Therapeutics
Menlo Park, CA
Kelly Loyet
Patrick Lupardus
Bin Ma
Michael T. Marty
Rebecca Melmon
Madyson Migliozzi
Department of Pharmaceutical Development
Zora Modrusan
Farhana Afrin Mohona
Huy Nguyen
Emma Pelegri-O'Day
Amgen Research, Amgen Inc.
Qui T. Phung
Emile Plise
Markus A. Queisser
Modality Platform Technologies, GSK
Medicines Research Centre
Stevenage
UK
Roshan M. Regy
Amber D. Rolland
Ola M. Saad
Sudeshna Sadhu
Adaptive...
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