Diabetes and Kidney Disease

Background-History

Part I: Natural Course, Pathogenesis, Morphology and Genetics

1. Diabetic Nephropathy-Scope of the problem (Epidemiology, US, Japan, Europe, Obesity (Metabolic Syndrome) Geriatrics
2. Natural Course (Stages/Evidence Based Discussion)
3. Pathogenesis: Biochemical and functional alterations involving the GBM and mesangium
4. Pathogenesis: Hemodynamic alterations/renin angiotensin system
5. Renal structural damage in type 1 and type 2 DM
6. Diabetes in children and adolescents
7. Genetic markers and predictors of DN

Part II: Clinical Presentation and Associated Disorders

8. Screening and early diagnosis (E. Cohen - Milwaukee)
9. Differential diagnosis of proteinuria in DM (A. Reddi, NJ Med Sch)
10. Hypertension in DM
11. Cardiovascular Disease (L. Hamm, Tulane)
12. Lipid disorders
13. Eye complications in DN (Z. Karcioglu, U. Virginia)
14. Pregnancy and DN (K. Krane-Tulane)
15. Transplantation: Kidney, Kidney-Pancreas (R. Zhang)

Part III: Treatment and Prognosis

16. Glycemic control
17. BP control in hypertensive diabetics with proteinuria
18. Early antihypertensive treatment in early stages of DN
19. Lifestyle modifications
20. Novel treatments (stem cells, islet cell transplants, gene transfer, etc.)