This volume of Progress in Brain Research is based on the proceedings of a conference, "Using Eye Movements as an Experimental Probe of Brain Function," held at the Charing Cross Hospital Campus of Imperial College London, UK on 5th -6th December, 2007 to honor Professor Jean Büttner-Ennever. With 87 contributions from international experts - both basic scientists and clinicians - the volume provides many examples of how eye movements can be used to address a broad range of research questions. Section 1 focuses on extraocular muscle, highlighting new concepts of proprioceptive control that involve even the cerebral cortex. Section 2 comprises structural, physiological, pharmacological, and computational aspects of brainstem mechanisms, and illustrates implications for disorders as diverse as opsoclonus, and congenital scoliosis with gaze palsy. Section 3 addresses how the cerebellum transforms neural signals into motor commands, and how disease of such mechanisms may lead to ataxia and disorders such as oculopalatal tremor. Section 4 deals with sensory-motor processing of visual, vestibular, somatosensory, and auditory inputs, such as are required for navigation, and gait. Section 5 illustrates how eye movements, used in conjunction with single-unit electrophysiology, functional imaging, transcranial magnetic stimulation, and lesion studies have illuminated cognitive processes, including memory, prediction, and even free will. Section 6 includes 18 papers dealing with disorders ranging from congenital to acquired forms of nystagmus, genetic and degenerative neurological disorders, and treatments for nystagmus and motion sickness.
* Clinicians will find important new information on the substrate for spinocerebellar ataxia, late-onset Tay-Sachs disease, Huntington disease, and pulvinar lesions
* Organizes multiple articles on such topics as proprioception, short and longer-term memory, and hereditary cerebellar ataxias for a more coherent presentation
* Articles on anatomic tracers, functional imaging, and computational neuroscience are illustrated in color
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
ISBN-13
978-0-08-093232-3 (9780080932323)
Schweitzer Klassifikation
Section 1: Using Novel Techniques to Define the Neural Substrate for Eye Movements Jean Büttner-Ennever, Munich: Re-mapping the oculomotor systemJoseph Demer, Los Angeles: Using high-definition MRI to re-define the mechanics of eye rotationsMichael Goldberg, New York: The cortical representation of oculomotor proprioceptionDavid Zee, Baltimore: How new knowledge of the anatomy of the eye muscles and their innervation translates into improved treatment of patients with ocular motor palsiesPaul Knox, Liverpool: Testing the influences of extraocular proprioception in humans James Sharpe, Toronto: Reinterpreting palsies of the ocular motor nerves Dominik Straumann: New insights into trochlear nerve palsyPaul May: Anatomical insights into peripheral gaze controlLouis Dell'Osso: How disrupting ocular proprioception can be therapy for congenital nsyatgmusSection 2: New Insights into Brainstem Generation of Ocular Motor CommandsAnja Horn, Munich: New insights into the circuitry and pharmacology of the brainstem reticular formationEdward Keller, San Francisco: Using multiple electrode arrays to map moving fields of neural activity in the superior colliculusPaul Gamlin, Birmingham: Synthesis of vergence control by brainstem circuitsHolger Rambold, Lübeck: Disturbances of vergence and saccadic eye movements by human brainstem lesionsChristoph Helmchen, Luebeck: Understanding how the cerebellar disease could cause saccadic oscillationsStefano Ramat, Pavia: A brainstem network that accounts for abnormal saccadesMark Gibson, Belfast: Human saccadic disorders and their brainstem mechanismsRichard Clement: A black-box approach to saccadic disordersSection 3: Using Eye Movements as an Index of Transformation of Signals by the CerebellumStephen Highstein, St.
