Integrated Strategies for Drug Discovery Using Mass Spectrometry

Preface.
List of Contributors.
Acknowledgements.
1. Miniaturized Formats for Efficient Liquid Chromatography MassSpectrometry-Based Proteomics and Therapeutic Development. (Gary A.Valaskovic and Neil L. Kelleher).
2. Mass-Spectrometry-Based Drug Screening Assays for EarlyPhases in Drug Discovery. (Marshall M. Siegel).
3. ESI-FTICR as a High Throughput Drug Discovery Platform.(Kristin A. Sannes-Lowery, Lendell L. Cummins, Shuo Chen, Jared J.Drader, and Steven A. Hofstadler).
4. Mass Spectrometry- Based Proteomic Approaches for DiseaseDiagnosis and Biomarker Discovery. (Thomas P. Conrads, Haleem J.Issaq, Josi S. Blonder, and Timothy D. Veenstra).
5. Metabonomic Applications in Toxicity Screening and DiseaseDiagnosis. (John P. Shockcor and Elaine Holmes).
6. The Central Role of Mass Spectrometry in Natural ProductsDiscovery. (Jeffrey R. Gilbert, Paul Lewer, Dennis O. Duebelbeis,Andrew W. Carr).
7. Application of Mass Spectrometry to Compound LibraryGeneration, Analysis, and Management. (Xueheng Cheng and JillHochlowski).
8. A Combinatorial Process for Drug Discovery. (David S. Wagner,Richard W. Wagner, Frank Schoenen, and H. Mario Geysen).
9. Application of Technological Advances in BiotransformationStudies. (Carmen L. Fernàndez-Metzler, Raju Subramanian andRichard C. King).
10. Applications of Mass Spectrometry for the Characterizationof Reactive Metabolites of Drugs in Discovery. (Jim Wang, JackWang, Margaret Davis, William DeMaio, JoAnn Scatina, and RasmyTalaat).
11. Advances in High Throughput Quantitative Drug DiscoveryBioanalysis. (Bradley L. Ackermann, Michael J. Berna, and AnthonyT. Murphy).
12. New Strategies for the Implementation and Support ofBioanalysis in a Drug Metabolism Environment. (Walter A.Korfmacher).
13. An Integrated LC-MS Strategy for Preclinical CandidateOptimization. (Jonathan L. Josephs and Mark Sanders).
14. New Approaches for Method Development and Purification inLead Optimization. (Yining Zhao and David J. Semin).
15. High Throughput Metabolic and Physicochemical PropertyAnalysis: Strategies and Tactics for Impact on Drug DiscoverySuccess. (Edward H. Kerns and Li Di).
16. Organ Perfusion and Mass Spectrometry. (C. Gerald Curtis,Ben Chien, David Bar-Or, and Kumar Ramu).
17. Sample Preparation for Drug Discovery Bioanalysis.(David A.Wells).
18. Automation. (John D. Laycock and Thomas Hartmann).
Index.