The use of animal models is a key aspect of scientific research in numerous fields of medicine. This book vigorously examines the important contributions and application of animal models to the understanding of human movement disorders and will serve as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders. A vital feature of this book is an accompanying DVD with video clips of human movement disorders and their corresponding animal models. The book is divided into sections on Parkinson disease, Huntington disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders.
* Provides a single comprehensive resource on animal models of movement disorders that academic clinicians, translational researchers, and basic neuroscientists can refer to
* Includes contributions by expert movement disorder clinicians and top-level researchers in the field
* Features a DVD containing over 170 video clips of human movement disorders and the corresponding animal models
Sprache
Verlagsort
Verlagsgruppe
Elsevier Science & Techn.
ISBN-13
978-0-08-047056-6 (9780080470566)
Schweitzer Klassifikation
Table of ContentsPreface List of ContributorsSection A: Scientific Foundations A1: Classification and Clinical Features of Movement Disorders A2: Animal Models and the Science of Movement Disorders A3: Generation of Transgenic and Gene-Targeted Mouse Models of Movement Disorders A4: Genetics of Spontaneous Mutations in Mice A5: Assessment of Movement Disorders in Rodents A6: Response Dynamics: Measurement of the Force and Rhythm of Motor Responses in Laboratory Animals A7: Behavior in Drosophila: Analysis and Control A8: Use of C. elegans to Model Human Movement Disorders Section B: Parkinson Disease B1: The Phenotypic Spectrum of Parkinson Disease B2: MPTP-Induced Nigrostriatal Injury in Nonhuman Primates B3: From Man to Mouse: The MPTP Model of Parkinson Disease B4: Rotenone Rat and Other Neurotoxin Models of Parkinson Disease B5: Drosophila Models of Parkinson Disease B6: Phenotypical Characterization of Genetic Mouse Models of Parkinson Disease B7: Utility of 6-Hydroxydopamine Lesioned Rats in the Preclinical Screening of Novel Treatments for Parkinson Disease B8: Motor Complications in Primate Models of Parkinson Disease B9: C.