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Sylvia Asa, MD, PhD, Clinical Department Head, Department of Laboratory Medicine and Pathobiology, University of Toronto, University Health Network and Ontario Cancer Institute, Toronto, Canada.
Edward R. Laws, MD, FACS, Director, Pituitary/Neuroendocrine Center, Department of Neurosurgery, Brigham & Women's Hospital, Harvard University, Boston, Massachusetts, USA.
Shereen Ezzat, FACO, FRCPC, MD, Professor of Medicine & Oncology Head, Endocrine Oncology Site Group, Princess Margaret Hospital, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada.
Linda Rio, MA, MFT, Pituitary Network Association, Los Angeles, California, USA.
List of Contributors, ix
Introduction, xivRobert Knutzen
Abbreviations, xvi
Section 1: Overview
1 The Endocrine System, 3Sylvia L. Asa and Shereen Ezzat
2 Signs and Symptoms of Pituitary Disease, 13
Physical Manifestations of Pituitary Disorders, 13Eva Fernandez-Rodriguez, Ignacio Bernabeu, and Felipe F. Casanueva
Emotional Manifestations of Pituitary Disorders, 15Eva N. Kassi, Gregory A. Kaltsas, and George P. Chrousos
Mental Health Aspects of Pituitary Disorders, 17Valerie Golden
Section 2: Disorders
3 Acromegaly, 23Shereen Ezzat
4 Secondary Adrenal Insuffi ciency, 32Tobias Else and Richard J. Auchus
5 Adult Growth Hormone Deficiency, 47T. Brooks Vaughan III, Kristen Owen Riley, and Lewis S. Blevins Jr.
6 Pituitary Carcinoma, 55Sylvia L. Asa
7 Craniopharyngioma, 59Jessica K. Devin
8 Cushing's Syndrome, 67Lewis S. Blevins Jr.
9 Empty Sella Syndrome, 77Michael C. Oh and Manish K. Aghi
10 Familial Pituitary Adenomas, 87Laura C. Hernández-Ramírez and Márta Korbonits
11 Follicle Stimulating Hormone and Luteinizing Hormone Secreting Tumors, 111Bahram Khazai, Ronald S. Swerdloff, and Christina Wang
12 Hypopituitarism, 120Klara J. Rosenquist and Ursula B. Kaiser
13 Clinically Nonfunctioning Pituitary Adenomas, 130Brandon A. Miller, Adriana G. Ioachimescu, and Nelson M. Oyesiku
14 Prolactinoma, 138Luis G. Sobrinho
15 Rathke's Cleft Cysts, 146Seunggu J. Han, Arman Jahangiri, and Manish K. Aghi
16 Thyroid Hormone Deficiency, 153Whitney W. Woodmansee
17 Thyroid Stimulating Hormone Secreting Tumor, 159Andrea Lania, Luca Persani, and Paolo Beck-Peccoz
18 Pituitary Disorders - Specific Issues for Women, 167Maria Fleseriu, Christine G. Yedinak, Jessica Brzana, and Shirley McCartney
19 Hypogonadism and Male Sexual Function, 179Prasanth N. Surampudi, Christina Wang, and Ronald S. Swerdloff
20 Pituitary Disorders Specific to Children, 193Kathryn Pade and Mitchell E. Geffner
Section 3: Diagnosing Pituitary Disorders
21 Physical Examination , 207Laurence Katznelson
22 Pituitary Endocrine Function Testing , 213Shereen Ezzat
Section 4: Treatment of Pituitary Disorders
23 Medical Management of Pituitary Adenomas , 227Paolo Cappabianca, Daniel M. Prevedello, Michelangelo de Angelis, Andressa Bornschein, Leo F. S. Ditzel Filho, Domenico Solari, Ricardo L. Carrau, Felice Esposito, Danielle de Lara, Luigi M. Cavallo, and Annamaria Colao
24 Surgical Management of Pituitary Disorders , 243
Pure Endoscopic Transsphenoidal Surgery, 243Gautam U. Mehta and John A. Jane Jr.
Open Transcranial Approaches to the Sella, 245Ian F. Dunn
Endoscopic Skull Base Approaches, 247Tong Yang and Theodore H. Schwartz
Transnasal Endoscope-Assisted Transsphenoidal Approach for Pituitary Tumors, 248Huy T. Duong and Daniel F. Kelly
25 Stereotactic Radiosurgery for Pituitary Adenomas, 255Brian J. Williams, Stephen J. Monteith, and Jason P. Sheehan
26 Hormone Replacement Therapy, 265
Growth Hormone Deficiency in Adults, 265Joseph A. M. J. L. Janssen and Aart Jan van der Lely
Growth Hormone Deficiency in Children and Adolescents, 269Alan D. Rogol
Pituitary Hormone Replacement in Women, 272Adriana G. Ioachimescu
Section 5: Complications that Accompany Pituitary Disease
27 Complications of Pituitary Disease, 279
Cardiac Complications, 279Ludovica F. S. Grasso, Alessia Cozzolino , and Annamaria Colao
Cognitive Dysfunction, 280Krystallenia I. Alexandraki, Gregory A. Kaltsas, and George P. Chrousos
Diabetes Insipidus, 281Marco Faustini-Fustini and Giorgio Frank
Headaches, 282Paul B. Rizzoli
Obesity, 283Andrea L. Utz
Osteoporosis, 284Andrea L. Utz
Permanent Hormone Deficiency, 285Andrea L. Utz
Visual Deficits Caused by Pituitary Tumors, 286Sashank Prasad
Section 6: General Psychological and Psychosocial Effects
28 General Psychological and Psychosocial Effects of Pituitary Disorders, 293Valerie Golden
Section 7: Long Term: What You and Your Patients Can Expect 29 Living with Pituitary Disease, 303Jessica K. Devin
Section 8: Research and Clinical Trials
30 Research and Clinical Trials, 313Brittany P. Sumerel and Anthony P. Heaney
Section 9: Resources
31 Fundamentals of Pituitary Pathology, 325Sylvia L. Asa
Glossary, 333Pejman Cohan
Index, 347
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