3D Printing of Pharmaceutical and Drug Delivery Devices

Name: 3D Printing of Pharmaceutical and Drug Delivery Devices | Progress from Bench to Bedside
Brand: Wiley-ISTE
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Progress from Bench to Bedside

Dimitrios A. Lamprou Dennis Douroumis Sheng Qi(Herausgeber*in)

Wiley-ISTE (Verlag)

1. Auflage

Erschienen am 15. Mai 2024

272 Seiten

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978-1-119-83599-8 (ISBN)

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Inhalt

Intro
3D Printing of Pharmaceutical and Drug Delivery Devices
Contents
About the Editors
List of Contributors
Series Preface
Preface
1 Materials for 3D Printing
1.1 Introduction
1.2 Material Processability Considerations for Pharmaceutical 3DP
1.2.1 Thermal Extrusion-Based 3D Printing
1.2.1.1 Thermal Considerations
1.2.1.2 Solubility Enhancement
1.2.1.3 Mechanical Considerations
1.2.2 Semi-Solid Extrusion 3DP
1.2.2.1 Rheological Considerations
1.2.2.2 Example Applications
1.2.3 Powder Bed Fusion 3D Printing
1.2.3.1 Powder Flowability Considerations
1.2.3.2 Powder Packing Density Considerations
1.2.3.3 Powder Energy Absorbance Considerations
1.2.4 Stereolithography 3D Printing
1.3 Classification of Common Materials Used in Pharmaceutical 3DP
1.3.1 Alcohol Derived Polymers
1.3.2 Eudragits
1.3.3 Other Polymers
1.3.4 Graft Polymers
1.3.5 Photocrosslinkable
1.3.6 Natural Materials
1.3.7 Lipid Materials
1.4 Conclusions and Future Perspectives
References
2 The Use of Microstructure Design and 3D Printing for Tailored Drug Release
2.1 Introduction
2.2 3D-Printing Technologies
2.3 3D Design for Drug-Loaded Device
2.3.1 CAD Design-Based Design
2.3.2 Computational Software-Based Design
2.3.3 3D-Printing Parameter-Based Design
2.3.4 Polypills and Complex Designs
2.4 3D Designs Influence Drug Release
2.4.1 Controlling Drug Release
2.4.2 Modifying Drug Release
2.5 Challenges and Perspective
References
3 3D Printing of Oral Solid Dosage Forms Using Selective Laser Sintering
3.1 Introduction
3.2 Operational Principles of Selective Laser Sintering
3.2.1 Manufacturing Challenges for SLS
3.2.2 Laser Selection and Scanning Speed
3.2.3 Powder Material Parameters
3.2.4 Powder Bed and Recoater Parameters
3.3 3D-Printed Oral Dosages
3.4 Advantages of SLS
3.4.1 Printing Features
3.4.2 Control of Surface Properties
3.4.3 Printing of Complex Geometries
3.4.4 Using a Wide Range of Materials
3.4.5 Drug Loading and Dose Combinations
3.4.6 Personalised Dosage Forms
3.4.7 SLS Disadvantages
3.5 Conclusions
References
4 3D Printing for Medical Device Applications
4.1 Introduction
4.2 3D Printers
4.2.1 SLA
4.2.2 FFF
4.2.3 Selective Laser Sintering (SLS)
4.3 Biomaterials for 3D-Printed Medical Devices
4.3.1 Bioresorbable Polymers
4.3.1.1 Synthetic Bioresorbable Polymers
4.3.1.2 Natural Bioresorbable Polymers
4.3.2 Non-Bioresorbable Polymers
4.3.3 Smart Polymers
4.3.4 Metal and Ceramic
4.4 3D-Printed Personalised Medical Devices
4.4.1 Vascular Repair Devices
4.4.2 Splints
4.4.3 Nerve Guidance Conduits
4.4.4 Tissue Engineering
4.4.5 3D Printing in Dentistry
4.4.6 3D-Printed Orthopaedic Devices
4.5 Regulatory
4.6 Future Perspectives
References
5 3D Printed Implants for Long-Acting Drug Delivery
5.1 Introduction
5.2 Types of 3D-Printed Scaffolds
5.2.1 Implantable Scaffolds
5.2.1.1 Passive Implants
5.2.1.2 Active Implants
5.2.2 Injectable Scaffolds
5.2.3 Innovative 3D-Printed Scaffolds
5.3 Critical Parameters in Designing 3D-Printed Implantable Scaffolds
5.3.1 Structural Characteristics
5.3.1.1 Geometry of Implants
5.3.1.2 Porosity Properties and Pore Features
5.3.1.3 Surface Properties
5.3.2 Mechanical Properties
5.3.3 Biological and Physiological Parameters
5.3.3.1 Cellular Adhesion
5.3.3.2 Absorption and Degradation Rates
5.3.3.3 Biocompatibility Aspects
5.4 Critical Parameters in Selecting Materials for 3D-Printed Scaffolds
5.4.1 Materials Used in 3D-Printed Long-Acting Scaffolds
5.4.1.1 Natural Polymers
5.4.1.2 Synthetic Polymers
5.4.1.3 Ceramics and Metals
5.4.1.4 Composites
References
5.5 Manufacturing Techniques for Implantable Scaffolds
5.5.1 Hot-Melt Extrusion
5.5.2 Compression
5.5.3 Injection Moulding
5.5.4 Solvent Casting
5.5.5 3D Printing
5.5.6 Scale-Up in 3D-Printing Process for the Manufacturing of Scaffolds
5.6 Drug Release Mechanism of Long-Acting 3D-Printing Polymeric Implantable Systems
5.7 Outlining Regulatory Framework for 3D-Printed Implantable Scaffolds
5.7.1 Commercial Implantable Scaffolds
5.8 Conclusions
References
6 Wound Dressings by 3D Printing
6.1 Wound Healing Process
6.1.1 Haemostasis/Coagulation
6.1.2 Inflammation
6.1.3 Proliferation
6.1.4 Re-epithelisation/Remodelling
6.1.5 Wound Classification
6.1.6 Wound Dressings
6.1.7 3D Printing
6.1.8 3D-Printed Dressings
6.2 Case Studies
6.3 Summary/Conclusions
References
7 3D Printing of Hydrogels
7.1 Introduction
7.2 Applications of 3D-Printed Hydrogels
7.2.1 Tissue Engineering
7.2.2 Wound Healing
7.2.3 Drug Delivery
7.3 Types of Hydrogel Materials for 3D Printing
7.3.1 Natural Polymers
7.3.2 Synthetic Polymers
7.3.3 Natural-Synthetic Hybrid Polymers
7.3.4 Ionically Charged Polymers
7.3.5 Crosslinked Polymers
7.3.6 Method of Hydrogel Preparation
7.4 3D Printing Techniques for Hydrogels
7.4.1 Laser-Based 3D Printing
7.4.1.1 Stereolithography
7.4.1.2 Two-Photon Polymerisation
7.4.1.3 Laser-Induced Forward Transfer
7.4.2 Extrusion-Based Printing
7.4.3 Inkjet-Based Printing
7.5 Printability and Printing Parameters
7.5.1 Bioink Design
7.5.1.1 Materials Selection, Concentration and Viscosity
7.5.1.2 Rheological Properties
7.5.1.3 Shear-Thinning
7.5.1.4 Viscoelasticity and Yield Stress
7.5.1.5 Cell Encapsulation
7.5.2 Crosslinking Techniques
7.5.2.1 Thermal Crosslinking
7.5.2.2 Physical Ionic Crosslinking
7.5.2.3 Chemical Crosslinking
7.5.2.4 Photocrosslinking
7.5.3 3D Printing Parameters
7.5.3.1 Temperature
7.5.3.2 Pressure
7.5.3.3 Speed
7.6 Clinical Translation
7.6.1 Regulatory Considerations
7.6.2 Manufacturing Considerations
7.6.3 Limitations and Future Direction
7.7 Conclusions
References
8 Analytical Characterisation of 3D-Printed Medicines
8.1 Introduction
8.2 Preformulation
8.2.1 Thermal Analysis
8.2.2 X-Ray Powder Diffraction (XRPD)
8.2.3 Infrared Spectroscopy
8.2.4 Hot-Stage Microscopy (HSM)
8.2.5 Customizsd Sample Preparation for the Preformulation Protocol
8.3 In-Process Characterisations
8.3.1 Mechanical Analysis
8.3.2 Rheological Analysis
8.3.3 Drug Characterisation
8.4 Final Product
8.4.1 Morphological Analysis
8.4.2 X-Ray Computed Microtomography (XµCT)
8.4.3 Terahertz Pulsed Imaging (TPI)
8.4.4 Mercury Porosimetry
8.4.5 Helium Pycnometry
8.5 Conclusions
References
9 Adoption of 3D Printing in Pharmaceutical Industry
9.1 Partnering and Growing
9.2 Regulatory Strategy
9.2.1 Product Development
9.2.2 Manufacturing
9.3 Business Model
9.3.1 In-House Pipeline Products
9.3.2 Co-Development
9.4 Regulatory Strategy
9.5 Partnering and Growing
9.6 Business Model and Strategy
9.6.1 Closing Remarks
References
10 Clinical Benefits of 3D Printing in Healthcare
10.1 Introduction
10.2 3D Printing Technologies
10.2.1 Binder Jetting
10.2.2 Vat Photopolymerization
10.2.3 Powder Bed Fusion
10.2.4 Material Jetting
10.2.5 Material Extrusion
10.2.5.1 Fused Deposition Modelling
10.2.5.2 Semi-Solid Extrusion
10.2.5.3 Direct Powder Extrusion
10.3 Preclinical Applications of 3D Printing
10.3.1 Immediate and Modified Release Oral Printlets
10.3.2 3D-Printed Drug Delivery Devices for Other Routes of Administration
10.4 Clinical Applications of 3D Printing
10.4.1 Personalised Medications
10.4.2 Improved Acceptability and Medication Compliance
10.4.2.1 Paediatric Patients
10.4.2.2 Adult and Geriatric Patients
10.4.3 Mass Manufacturing
10.4.4 Decentralised On-Demand Fabrication
10.4.5 Veterinary Applications
10.5 Challenges, Regulatory View and Future Applications
10.6 Conclusion
References
11 Regulatory Aspects of 3D-Printed Medicinal Products
11.1 Introduction
11.2 Current Regulatory Framework
11.3 Quality Aspects of 3D-Printed Medicinal Products
11.4 3D-Printed Paediatric Medicinal Products
11.5 3D-Printed Systems With Tailored Release Profiles
11.6 Conclusions
Disclaimer
References
Index
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